Sign in Blood

Target player draws two cards and loses 2 life.

Amalia Benavides Aguirre

Ward—Pay 3 life.
Whenever you gain life, Amalia Benavides Aguirre explores. Then destroy all other creatures if its power is exactly 20. (To have this creature explore, reveal the top card of your library. Put that card into your hand if it's a land. Otherwise, put a +1/+1 counter on this creature, then put the card back or put it into your graveyard.)

Caduceus, Staff of Hermes

Equipped creature has lifelink.
As long as you have 30 or more life, equipped creature gets +5/+5 and has indestructible and "Prevent all damage that would be dealt to this creature."
Equip {W}{W}

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Sorin, Ravenous Neonate

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
+2: Create a Food token.
−1: Sorin, Ravenous Neonate deals damage equal to the amount of life you gained this turn to any target.
−6: Gain control of target creature. It becomes a Vampire in addition to its other types. Put a lifelink counter on it if you control a white permanent other than that creature or Sorin.

Sorin of House Markov

Lifelink
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
At the beginning of each of your postcombat main phases, if you gained 3 or more life this turn, exile Sorin of House Markov, then return him to the battlefield transformed under his owner's control.

Sorin of House Markov // Sorin, Ravenous Neonate

Orzhov Signet

Path of Ancestry

Path of Ancestry enters tapped.
{T}: Add one mana of any color in your commander's color identity. When that mana is spent to cast a creature spell that shares a creature type with your commander, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Stroke of Midnight

Destroy target nonland permanent. Its controller creates a 1/1 white Human creature token.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Vengeful Bloodwitch

Whenever this creature or another creature you control dies, target opponent loses 1 life and you gain 1 life.

Exemplar of Light

Flying
Whenever you gain life, put a +1/+1 counter on this creature.
Whenever you put one or more +1/+1 counters on this creature, draw a card. This ability triggers only once each turn.

Soul Warden

Whenever another creature enters, you gain 1 life.

Carmen, Cruel Skymarcher

Flying
Whenever a player sacrifices a permanent, put a +1/+1 counter on Carmen, Cruel Skymarcher and you gain 1 life.
Whenever Carmen attacks, return up to one target permanent card with mana value less than or equal to Carmen's power from your graveyard to the battlefield.

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Markov Purifier

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay {2}. If you do, draw a card.

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Restless Fortress

Restless Fortress enters tapped.
{T}: Add {W} or {B}.
{2}{W}{B}: Restless Fortress becomes a 1/4 white and black Nightmare creature until end of turn. It's still a land.
Whenever Restless Fortress attacks, defending player loses 2 life and you gain 2 life.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Ajani's Pridemate

Whenever you gain life, put a +1/+1 counter on Ajani's Pridemate.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Elenda, Saint of Dusk

Lifelink, hexproof from instants
As long as your life total is greater than your starting life total, Elenda gets +1/+1 and has menace. Elenda gets an additional +5/+5 as long as your life total is at least 10 greater than your starting life total.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Sol Ring

Fracture

Destroy target artifact, enchantment, or planeswalker.

High-Society Hunter

Flying
Whenever this creature attacks, you may sacrifice another creature. If you do, put a +1/+1 counter on this creature.
Whenever another nontoken creature dies, draw a card.

Spymaster's Vault

Spymaster's Vault enters tapped unless you control a Swamp.
{T}: Add {B}.
{B}, {T}: Target creature you control connives X, where X is the number of creatures that died this turn. (Draw X cards, then discard X cards. Put a +1/+1 counter on that creature for each nonland card discarded this way.)

Vampire of the Dire Moon

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Blade of the Bloodchief

Whenever a creature dies, put a +1/+1 counter on equipped creature. If equipped creature is a Vampire, put two +1/+1 counters on it instead.
Equip {1}

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

Elenda's Hierophant

Flying
Whenever you gain life, put a +1/+1 counter on Elenda's Hierophant.
When Elenda's Hierophant dies, create X 1/1 white Vampire creature tokens with lifelink, where X is its power.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Felidar Sovereign

Vigilance (Attacking doesn't cause this creature to tap.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your upkeep, if you have 40 or more life, you win the game.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Radiant Fountain

When Radiant Fountain enters, you gain 2 life.
{T}: Add {C}.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Elenda, the Dusk Rose

Lifelink
Whenever another creature dies, put a +1/+1 counter on Elenda, the Dusk Rose.
When Elenda dies, create X 1/1 white Vampire creature tokens with lifelink, where X is Elenda's power.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Vault of Champions

Vault of Champions enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

The Gaffer

At the beginning of each end step, if you gained 3 or more life this turn, draw a card.

Swamp

Shroudstomper

Deathtouch
Whenever Shroudstomper enters or attacks, each opponent loses 2 life. You gain 2 life and draw a card.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Soul's Attendant

Whenever another creature enters, you may gain 1 life.

Cleric Class

(Gain the next level as a sorcery to add its ability.)
If you would gain life, you gain that much life plus 1 instead.
{3}{W}: Level 2
Whenever you gain life, put a +1/+1 counter on target creature you control.
{4}{W}: Level 3
When this Class becomes level 3, return target creature card from your graveyard to the battlefield. You gain life equal to that creature's toughness.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Nazar, the Velvet Fang

Menace (This creature can't be blocked except by two or more creatures.)
Whenever you gain life, put a feeding counter on Nazar, the Velvet Fang.
Whenever Nazar attacks, you may remove three feeding counters from it. If you do, you draw three cards and you lose 3 life.

Vindicate

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Infernal Grasp

Destroy target creature. You lose 2 life.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Pristine Talisman

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Isolated Chapel

Isolated Chapel enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Bond of Discipline

Tap all creatures your opponents control. Creatures you control gain lifelink until end of turn.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Arcane Signet

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.