Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on this enchantment. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if this enchantment has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

The Ancient One

Descend 8 — The Ancient One can't attack or block unless there are eight or more permanent cards in your graveyard.
{2}{U}{B}: Draw a card, then discard a card. When you discard a card this way, target player mills cards equal to its mana value.

Duskmantle Guildmage

{1}{U}{B}: Whenever a card is put into an opponent's graveyard from anywhere this turn, that player loses 1 life.
{2}{U}{B}: Target player mills two cards.

The Mindskinner

The Mindskinner can't be blocked.
If a source you control would deal damage to an opponent, prevent that damage and each opponent mills that many cards.

Zellix, Sanity Flayer

Hive Mind — Whenever a player mills one or more creature cards, you create a 1/1 black Horror creature token.
{1}, {T}: Target player mills three cards.
Choose a Background (You can have a Background as a second commander.)