Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Urza's Guilt

Each player draws two cards, then discards three cards, then loses 4 life.

Laquatus's Champion

When Laquatus's Champion enters, target player loses 6 life.
When Laquatus's Champion leaves the battlefield, that player gains 6 life.
{B}: Regenerate Laquatus's Champion.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Knight of Dusk's Shadow

Menace (This creature can't be blocked except by two or more creatures.)
Your opponents can't gain life.
{1}{B}: Knight of Dusk's Shadow gets +1/+1 until end of turn.

Vile Consumption

All creatures have "At the beginning of your upkeep, sacrifice this creature unless you pay 1 life."

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Clutch of the Undercity

Return target permanent to its owner's hand. Its controller loses 3 life.
Transmute {1}{U}{B} ({1}{U}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then shuffle. Transmute only as a sorcery.)

Duskmantle Seer

Flying
At the beginning of your upkeep, each player reveals the top card of their library, loses life equal to that card's mana value, then puts it into their hand.

Sygg, River Cutthroat

At the beginning of each end step, if an opponent lost 3 or more life this turn, you may draw a card. (Damage causes loss of life.)

Hunted Bonebrute

Menace
When Hunted Bonebrute enters, target opponent creates two 1/1 white Dog creature tokens.
When Hunted Bonebrute dies, each opponent loses 3 life.
Disguise {1}{B}