Cavalier of Dawn

Vigilance
When Cavalier of Dawn enters, destroy up to one target nonland permanent. Its controller creates a 3/3 colorless Golem artifact creature token.
When Cavalier of Dawn dies, return target artifact or enchantment card from your graveyard to your hand.

Argentum Armor

Equipped creature gets +6/+6.
Whenever equipped creature attacks, destroy target permanent.
Equip {6}

The Filigree Sylex

{T}: Put an oil counter on The Filigree Sylex.
{T}, Sacrifice The Filigree Sylex: Destroy each nonland permanent with mana value equal to the number of oil counters on The Filigree Sylex.
{T}, Remove ten oil counters from among permanents you control and sacrifice The Filigree Sylex: It deals 10 damage to any target.

Maelstrom Pulse

Destroy target nonland permanent and all other permanents with the same name as that permanent.

Unstable Obelisk

{T}: Add {C}.
{7}, {T}, Sacrifice Unstable Obelisk: Destroy target permanent.

Alpha Deathclaw

Menace, trample
When Alpha Deathclaw enters or becomes monstrous, destroy target permanent.
{5}{B}{G}: Monstrosity 4. (If this creature isn't monstrous, put four +1/+1 counters on it and it becomes monstrous.)

Drag to the Roots

Delirium — This spell costs {2} less to cast as long as there are four or more card types among cards in your graveyard.
Destroy target nonland permanent.

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap Staff of Compleation.

Spine of Ish Sah

When Spine of Ish Sah enters, destroy target permanent.
When Spine of Ish Sah is put into a graveyard from the battlefield, return Spine of Ish Sah to its owner's hand.

Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog, the Infinite Gyre is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Clay Golem

{6}, Roll a d8: Monstrosity X, where X is the result. (If this creature isn't monstrous, put X +1/+1 counters on it and it becomes monstrous.)
Berserk — When Clay Golem becomes monstrous, destroy target permanent.

Cindervines

Whenever an opponent casts a noncreature spell, Cindervines deals 1 damage to that player.
{1}, Sacrifice Cindervines: Destroy target artifact or enchantment. Cindervines deals 2 damage to that permanent's controller.

High Priest of Penance

Whenever High Priest of Penance is dealt damage, you may destroy target nonland permanent.

Skyfisher Spider

Reach
When Skyfisher Spider enters, you may sacrifice another creature. When you do, destroy target nonland permanent.
When Skyfisher Spider dies, you may gain 1 life for each creature card in your graveyard. If you do, exile Skyfisher Spider from your graveyard.

Lux Cannon

{T}: Put a charge counter on Lux Cannon.
{T}, Remove three charge counters from Lux Cannon: Destroy target permanent.

Crosis's Charm

Choose one —
• Return target permanent to its owner's hand.
• Destroy target nonblack creature. It can't be regenerated.
• Destroy target artifact.

Vraska the Unseen

+1: Until your next turn, whenever a creature deals combat damage to Vraska the Unseen, destroy that creature.
−3: Destroy target nonland permanent.
−7: Create three 1/1 black Assassin creature tokens with "Whenever this creature deals combat damage to a player, that player loses the game."

Bumbleflower's Sharepot

When Bumbleflower's Sharepot enters, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
{5}, {T}, Sacrifice Bumbleflower's Sharepot: Destroy target nonland permanent. Activate only as a sorcery.

Mortality Spear

This spell costs {2} less to cast if you gained life this turn.
Destroy target nonland permanent.

Universal Solvent

{7}, {T}, Sacrifice Universal Solvent: Destroy target permanent.

Cityscape Leveler

Trample
When you cast this spell and whenever Cityscape Leveler attacks, destroy up to one target nonland permanent. Its controller creates a tapped Powerstone token.
Unearth {8}

Behemoth of Vault 0

Trample
When Behemoth of Vault 0 enters, you get {E}{E}{E}{E} (four energy counters).
When Behemoth of Vault 0 dies, you may pay an amount of {E} equal to target nonland permanent's mana value. When you do, destroy that permanent.

Abrupt Decay

This spell can't be countered.
Destroy target nonland permanent with mana value 3 or less.

Atomize

Destroy target nonland permanent. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Argentum Masticore

First strike, protection from multicolored
At the beginning of your upkeep, sacrifice Argentum Masticore unless you discard a card. When you discard a card this way, destroy target nonland permanent an opponent controls with mana value less than or equal to the mana value of the discarded card.

Hydroblast

Choose one —
• Counter target spell if it's red.
• Destroy target permanent if it's red.

Goblin Cratermaker

{1}, Sacrifice Goblin Cratermaker: Choose one —
• Goblin Cratermaker deals 2 damage to target creature.
• Destroy target colorless nonland permanent.

Karmic Justice

Whenever a spell or ability an opponent controls destroys a noncreature permanent you control, you may destroy target permanent that opponent controls.

Excavation Technique

Demonstrate (When you cast this spell, you may copy it. If you do, choose an opponent to also copy it. Players may choose new targets for their copies.)
Destroy target nonland permanent. Its controller creates two Treasure tokens.

Vindicate

Capricious Efreet

At the beginning of your upkeep, choose target nonland permanent you control and up to two target nonland permanents you don't control. Destroy one of them at random.

Angel of Despair

Flying
When Angel of Despair enters, destroy target permanent.

Molten Collapse

Choose one. If you descended this turn, you may choose both instead. (You descended if a permanent card was put into your graveyard from anywhere.)
• Destroy target creature or planeswalker.
• Destroy target noncreature, nonland permanent with mana value 1 or less.

Rise of the Eldrazi

This spell can't be countered.
Destroy target permanent. Target player draws four cards. Take an extra turn after this one.
Exile Rise of the Eldrazi.

Void Rend

This spell can't be countered.
Destroy target nonland permanent.

Ugin, the Ineffable

Colorless spells you cast cost {2} less to cast.
+1: Exile the top card of your library face down and look at it. Create a 2/2 colorless Spirit creature token. When that token leaves the battlefield, put the exiled card into your hand.
−3: Destroy target permanent that's one or more colors.

Culling Scales

At the beginning of your upkeep, destroy target nonland permanent with the lowest mana value. (If two or more permanents are tied for lowest, target any one of them.)

Mythos of Nethroi

Destroy target nonland permanent if it's a creature or if {G}{W} was spent to cast this spell.

Vona, Butcher of Magan

Vigilance, lifelink
{T}, Pay 7 life: Destroy target nonland permanent. Activate only during your turn.

Vraska, Regal Gorgon

+2: Put a +1/+1 counter on up to one target creature. That creature gains menace until end of turn.
−3: Destroy target creature.
−10: For each creature card in your graveyard, put a +1/+1 counter on each creature you control.

Fall of the First Civilization

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — You and target opponent each draw two cards.
II — Exile target artifact an opponent controls.
III — Each player chooses three nonland permanents they control. Destroy all other nonland permanents.

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Despotic Scepter

{T}: Destroy target permanent you own. It can't be regenerated.

Assassin's Trophy

Destroy target permanent an opponent controls. Its controller may search their library for a basic land card, put it onto the battlefield, then shuffle.

Wild Magic Surge

Destroy target permanent an opponent controls. Its controller reveals cards from the top of their library until they reveal a permanent card that shares a card type with that permanent. They put that card onto the battlefield and the rest on the bottom of their library in a random order.

Destructive Revelry

Destroy target artifact or enchantment. Destructive Revelry deals 2 damage to that permanent's controller.

Pyroblast

Choose one —
• Counter target spell if it's blue.
• Destroy target permanent if it's blue.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Desert Twister

Stroke of Midnight

Destroy target nonland permanent. Its controller creates a 1/1 white Human creature token.

Beast Within

Destroy target permanent. Its controller creates a 3/3 green Beast creature token.

Convert to Slime

Destroy up to one target artifact, up to one target creature, and up to one target enchantment.
Delirium — Then if there are four or more card types among cards in your graveyard, create an X/X green Ooze creature token, where X is the total mana value of permanents destroyed this way.

Witherbloom Command

Choose two —
• Target player mills three cards, then you return a land card from your graveyard to your hand.
• Destroy target noncreature, nonland permanent with mana value 2 or less.
• Target creature gets -3/-1 until end of turn.
• Target opponent loses 2 life and you gain 2 life.

Windgrace's Judgment

For any number of opponents, destroy target nonland permanent that player controls.

Binding the Old Gods

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Destroy target nonland permanent an opponent controls.
II — Search your library for a Forest card, put it onto the battlefield tapped, then shuffle.
III — Creatures you control gain deathtouch until end of turn.

Goblin Firebomb

Flash
{7}, {T}, Sacrifice Goblin Firebomb: Destroy target permanent.

HELIOS One

{T}: Add {C}.
{1}, {T}: You get {E} (an energy counter).
{3}, {T}, Pay X {E}, Sacrifice HELIOS One: Destroy target nonland permanent with mana value X. Activate only as a sorcery.

Bladegriff Prototype

Flying
Whenever Bladegriff Prototype deals combat damage to a player, destroy target nonland permanent of that player's choice that one of your opponents controls.