Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Agent of Masks

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Vampiric Rites

{1}{B}, Sacrifice a creature: You gain 1 life and draw a card.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Sunlit Marsh

({T}: Add {W} or {B}.)
Sunlit Marsh enters tapped.

Sanguine Savior

Flying, lifelink
Disguise {W/B}{W/B} (You may cast this card face down for {3} as a 2/2 creature with ward {2}. Turn it face up any time for its disguise cost.)
When Sanguine Savior is turned face up, another target creature you control gains lifelink until end of turn.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Stroke of Midnight

Destroy target nonland permanent. Its controller creates a 1/1 white Human creature token.

Witch-Blessed Meadow

As Witch-Blessed Meadow enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {W}.

Witch Enchanter

When Witch Enchanter enters, destroy target artifact or enchantment an opponent controls.

Witch Enchanter // Witch-Blessed Meadow

Fireshrieker

Equipped creature has double strike. (It deals both first-strike and regular combat damage.)
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Angel of the Ruins

Flying
When Angel of the Ruins enters, exile up to two target artifacts and/or enchantments.
Plainscycling {2} ({2}, Discard this card: Search your library for a Plains card, reveal it, put it into your hand, then shuffle.)

Midnight Snack

Raid — At the beginning of your end step, if you attacked this turn, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
{2}{B}, Sacrifice this enchantment: Target opponent loses X life, where X is the amount of life you gained this turn.

Hidden Courtyard

Hidden Courtyard enters tapped.
{T}: Add {W}.
{4}{W}, {T}, Sacrifice Hidden Courtyard: Discover 4. Activate only as a sorcery. (Exile cards from the top of your library until you exile a nonland card with mana value 4 or less. Cast it without paying its mana cost or put it into your hand. Put the rest on the bottom in a random order.)

Fountainport Bell

When Fountainport Bell enters, you may search your library for a basic land card, reveal it, then shuffle and put that card on top.
{1}, Sacrifice Fountainport Bell: Draw a card.

Orzhov Signet

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Ivory Tower

At the beginning of your upkeep, you gain X life, where X is the number of cards in your hand minus 4.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Riot Control

You gain 1 life for each creature your opponents control. Prevent all damage that would be dealt to you this turn.

Plains

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Neglected Manor

Neglected Manor enters tapped unless a player has 13 or less life.
{T}: Add {W} or {B}.

Pristine Talisman

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Marchesa's Decree

When Marchesa's Decree enters, you become the monarch.
Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Swamp

Orzhov Guildgate

This land enters tapped.
{T}: Add {W} or {B}.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Ballroom

Ballroom enters tapped.
{T}: Add {W} or {B}.
{4}, {T}: Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Parasitic Impetus

Enchant creature
Enchanted creature gets +2/+2 and is goaded. (It attacks each combat if able and attacks a player other than you if able.)
Whenever enchanted creature attacks, its controller loses 2 life and you gain 2 life.

Worn Powerstone

Worn Powerstone enters tapped.
{T}: Add {C}{C}.

Sol Ring

God-Pharaoh's Statue

Spells your opponents cast cost {2} more to cast.
At the beginning of your end step, each opponent loses 1 life.

Marble Diamond

Marble Diamond enters tapped.
{T}: Add {W}.

Mortify

Secret Rendezvous

You and target opponent each draw three cards.

Gollum, Obsessed Stalker

Skulk (This creature can't be blocked by creatures with greater power.)
At the beginning of your end step, each opponent dealt combat damage this game by a creature named Gollum, Obsessed Stalker loses life equal to the amount of life you gained this turn.

Hidden Necropolis

Hidden Necropolis enters tapped.
{T}: Add {B}.
{4}{B}, {T}, Sacrifice Hidden Necropolis: Discover 4. Activate only as a sorcery. (Exile cards from the top of your library until you exile a nonland card with mana value 4 or less. Cast it without paying its mana cost or put it into your hand. Put the rest on the bottom in a random order.)

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Batwing Brume

Prevent all combat damage that would be dealt this turn if {W} was spent to cast this spell. Each player loses 1 life for each attacking creature they control if {B} was spent to cast this spell. (Do both if {W}{B} was spent.)

Sinister Monolith

At the beginning of combat on your turn, each opponent loses 1 life and you gain 1 life.
{T}, Pay 2 life, Sacrifice Sinister Monolith: Draw two cards. Activate only as a sorcery.

Sengir, the Dark Baron

Flying
Whenever another creature dies, put two +1/+1 counters on Sengir, the Dark Baron.
Whenever another player loses the game, you gain life equal to that player's life total as the turn began.
Partner (You can have two commanders if both have partner.)

Orzhov Locket

{T}: Add {W} or {B}.
{W/B}{W/B}{W/B}{W/B}, {T}, Sacrifice Orzhov Locket: Draw two cards.

Cloudkill

All creatures get -X/-X until end of turn, where X is the greatest mana value of a commander you own on the battlefield or in the command zone.

Cartographer's Hawk

Flying
When Cartographer's Hawk deals combat damage to a player who controls more lands than you, return it to its owner's hand. If you do, you may search your library for a Plains card, put it onto the battlefield tapped, then shuffle.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Inspiring Overseer

Flying
When this creature enters, you gain 1 life and draw a card.

Soul of Eternity

Soul of Eternity's power and toughness are each equal to your life total.
Encore {7}{W}{W} ({7}{W}{W}, Exile this card from your graveyard: For each opponent, create a token copy that attacks that opponent this turn if able. They gain haste. Sacrifice them at the beginning of the next end step. Activate only as a sorcery.)

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Angel of Vitality

Flying
If you would gain life, you gain that much life plus 1 instead.
This creature gets +2/+2 as long as you have 25 or more life.

Cut a Deal

Each opponent draws a card, then you draw a card for each opponent who drew a card this way.

Burnished Hart

{3}, Sacrifice this creature: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Essence of Ajani

(As this spell resolves, put it into the command zone.)
Whenever you cast a spell, you gain 1 life.

Slaughter the Strong

Each player chooses any number of creatures they control with total power 4 or less, then sacrifices all other creatures they control.

Tablet of the Guilds

As Tablet of the Guilds enters, choose two colors.
Whenever you cast a spell, if it's at least one of the chosen colors, you gain 1 life for each of the chosen colors it is.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Feast of the Victorious Dead

At the beginning of your end step, if one or more creatures died this turn, you gain that much life and distribute that many +1/+1 counters among creatures you control.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Ambition's Cost

You draw three cards and you lose 3 life.

Leyline of Hope

If Leyline of Hope is in your opening hand, you may begin the game with it on the battlefield.
If you would gain life, you gain that much life plus 1 instead.
As long as you have at least 7 life more than your starting life total, creatures you control get +2/+2.

Hero's Downfall

Makeshift Binding

When Makeshift Binding enters, exile target creature an opponent controls until Makeshift Binding leaves the battlefield. You gain 2 life.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Corpse Augur

When Corpse Augur dies, you draw X cards and you lose X life, where X is the number of creature cards in target player's graveyard.

Orzhov Basilica

Orzhov Basilica enters tapped.
When Orzhov Basilica enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Scoured Barrens

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {W} or {B}.

Healer's Hawk

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

The Gaffer

At the beginning of each end step, if you gained 3 or more life this turn, draw a card.

Ash Barrens

{T}: Add {C}.
Basic landcycling {1} ({1}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.