Localized Destruction

You get {E} (an energy counter), then you may pay one or more {E}. If you do, each creature you control with power equal to the amount of {E} paid this way gains indestructible until end of turn.
Destroy all creatures.

Tilonalli's Skinshifter

Haste
Whenever Tilonalli's Skinshifter attacks, it becomes a copy of another target nonlegendary attacking creature until end of turn.

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

The Battle of Bywater

Destroy all creatures with power 3 or greater. Then create a Food token for each creature you control. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Stuffy Doll

Indestructible
As Stuffy Doll enters, choose a player.
Whenever Stuffy Doll is dealt damage, it deals that much damage to the chosen player.
{T}: Stuffy Doll deals 1 damage to itself.

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Final Act

Choose one or more —
• Destroy all creatures.
• Destroy all planeswalkers.
• Destroy all battles.
• Exile all graveyards.
• Each opponent loses all counters.

Stampede Surfer

Haste
Whenever Stampede Surfer attacks, for each opponent, you create a 2/2 green Boar creature token that's tapped and attacking that opponent.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Sivitri, Dragon Master

+1: Until your next turn, creatures can't attack you or planeswalkers you control unless their controller pays 2 life for each of those creatures.
−3: Search your library for a Dragon card, reveal it, put it into your hand, then shuffle.
−7: Destroy all non-Dragon creatures.
Sivitri, Dragon Master can be your commander.

Brash Taunter

Indestructible
Whenever Brash Taunter is dealt damage, it deals that much damage to target opponent.
{2}{R}, {T}: Brash Taunter fights another target creature.

Tempest of Light

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Final Showdown

Spree (Choose one or more additional costs.)
+ {1} — All creatures lose all abilities until end of turn.
+ {1} — Choose a creature you control. It gains indestructible until end of turn.
+ {3}{W}{W} — Destroy all creatures.

Forest

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Wrath of God

Destroy all creatures. They can't be regenerated.

Tiamat's Fanatics

Haste
Myriad (Whenever this creature attacks, for each opponent other than defending player, you may create a token copy that's tapped and attacking that player or a planeswalker they control. Exile the tokens at end of combat.)

Ravages of War

Mountain

Purify

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Citywide Bust

Destroy all creatures with toughness 4 or greater.

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Armageddon

Planar Cleansing

Warchief Giant

Island

Child of Alara

Trample
When Child of Alara dies, destroy all nonland permanents. They can't be regenerated.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Damnation

Day of Judgment

Sunblast Angel

Flying
When Sunblast Angel enters, destroy all tapped creatures.

Cleanfall

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Ruination

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Split Up

Choose one —
• Destroy all tapped creatures.
• Destroy all untapped creatures.

Wakening Sun's Avatar

When Wakening Sun's Avatar enters, if you cast it from your hand, destroy all non-Dinosaur creatures.

Fated Retribution

Destroy all creatures and planeswalkers. If it's your turn, scry 2.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Fade from History

Each player who controls an artifact or enchantment creates a 2/2 green Bear creature token. Then destroy all artifacts and enchantments.

Swamp

Plains

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Back to Nature

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.