Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Ambition's Cost

You draw three cards and you lose 3 life.

Feast of Blood

Cast this spell only if you control two or more Vampires.
Destroy target creature. You gain 4 life.

Dark Impostor

{4}{B}{B}: Exile target creature and put a +1/+1 counter on Dark Impostor.
Dark Impostor has all activated abilities of all creature cards exiled with it.

Inevitable End

Enchant creature
Enchanted creature has "At the beginning of your upkeep, sacrifice a creature."

Necropolis Regent

Flying
Whenever a creature you control deals combat damage to a player, put that many +1/+1 counters on it.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Reaper's Talisman

Whenever equipped creature attacks, it gains deathtouch until end of turn.
Whenever equipped creature attacks alone, defending player loses 2 life and you gain 2 life.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Gift of Fangs

Enchant creature
Enchanted creature gets +2/+2 as long as it's a Vampire. Otherwise, it gets -2/-2.

Bringer of the Last Gift

Flying
When Bringer of the Last Gift enters, if you cast it, each player sacrifices all other creatures they control. Then each player returns all creature cards from their graveyard that weren't put there this way to the battlefield.

Champion of Dusk

When Champion of Dusk enters, you draw X cards and you lose X life, where X is the number of Vampires you control.

Markov Baron

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Lifelink
Other Vampires you control get +1/+1.
Madness {2}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Dreamdrinker Vampire

Lifelink
{1}{B}: Adapt 1. (If this creature has no +1/+1 counters on it, put a +1/+1 counter on it.)
Whenever one or more +1/+1 counters are put on Dreamdrinker Vampire, it gains menace until end of turn.

Queen's Bay Paladin

Whenever Queen's Bay Paladin enters or attacks, return up to one target Vampire card from your graveyard to the battlefield with a finality counter on it. You lose life equal to its mana value. (If a creature with a finality counter on it would die, exile it instead.)

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Abolisher of Bloodlines

Flying
When this creature transforms into Abolisher of Bloodlines, target opponent sacrifices three creatures of their choice.

Voldaren Pariah

Flying
Sacrifice three other creatures: Transform Voldaren Pariah.
Madness {B}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Voldaren Pariah // Abolisher of Bloodlines

Marauding Blight-Priest

Grasp of Darkness

Target creature gets -4/-4 until end of turn.

Sanguine Spy

Menace, lifelink
{1}, Sacrifice another creature: Surveil 1. (Look at the top card of your library. You may put that card into your graveyard.)
At the beginning of your end step, if there are five or more mana values among cards in your graveyard, you may pay 2 life. If you do, draw a card.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Vampire Spawn

When this creature enters, each opponent loses 2 life and you gain 2 life.

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Unexpected Fangs

Put a +1/+1 counter and a lifelink counter on target creature.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Trespasser's Curse

Enchant player
Whenever a creature enchanted player controls enters, that player loses 1 life and you gain 1 life.

Crossway Troublemakers

Attacking Vampires you control have deathtouch and lifelink. (Any amount of damage they deal to a creature is enough to destroy it. Damage dealt by those creatures also causes their controller to gain that much life.)
Whenever a Vampire you control dies, you may pay 2 life. If you do, draw a card.

Call of the Death-Dweller

Return up to two target creature cards with total mana value 3 or less from your graveyard to the battlefield. Put a deathtouch counter on either of them. Then put a menace counter on either of them.

Patron of the Vein

Flying
When Patron of the Vein enters, destroy target creature an opponent controls.
Whenever a creature an opponent controls dies, exile it and put a +1/+1 counter on each Vampire you control.

Bleed Dry

Target creature gets -13/-13 until end of turn. If that creature would die this turn, exile it instead.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Unlikely Aid

Target creature gets +2/+0 and gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Bloodchief's Thirst

Kicker {2}{B} (You may pay an additional {2}{B} as you cast this spell.)
Destroy target creature or planeswalker with mana value 2 or less. If this spell was kicked, instead destroy target creature or planeswalker.

Nighthawk Scavenger

Flying, deathtouch, lifelink
Nighthawk Scavenger's power is equal to 1 plus the number of card types among cards in your opponents' graveyards.

Demon of Loathing

Flying, trample
Whenever Demon of Loathing deals combat damage to a player, that player sacrifices a creature of their choice.

Whip of Erebos

Creatures you control have lifelink.
{2}{B}{B}, {T}: Return target creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step. If it would leave the battlefield, exile it instead of putting it anywhere else. Activate only as a sorcery.

Drag to the Bottom

Domain — Each creature gets -X/-X until end of turn, where X is 1 plus the number of basic land types among lands you control.

Gatekeeper of Malakir

Kicker {B} (You may pay an additional {B} as you cast this spell.)
When this creature enters, if it was kicked, target player sacrifices a creature of their choice.

Evolved Sleeper

{B}: Evolved Sleeper becomes a Human Cleric with base power and toughness 2/2.
{1}{B}: If Evolved Sleeper is a Cleric, put a deathtouch counter on it and it becomes a Phyrexian Human Cleric with base power and toughness 3/3.
{1}{B}{B}: If Evolved Sleeper is a Phyrexian, put a +1/+1 counter on it, then you draw a card and you lose 1 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Butcher of Malakir

Flying
Whenever Butcher of Malakir or another creature you control dies, each opponent sacrifices a creature of their choice.

Demonic Embrace

Enchant creature
Enchanted creature gets +3/+1, has flying, and is a Demon in addition to its other types.
You may cast Demonic Embrace from your graveyard by paying 3 life and discarding a card in addition to paying its other costs.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Knight of Dusk's Shadow

Menace (This creature can't be blocked except by two or more creatures.)
Your opponents can't gain life.
{1}{B}: Knight of Dusk's Shadow gets +1/+1 until end of turn.

Anowon, the Ruin Sage

At the beginning of your upkeep, each player sacrifices a non-Vampire creature of their choice.

Drana, Liberator of Malakir

Flying, first strike
Whenever Drana, Liberator of Malakir deals combat damage to a player, put a +1/+1 counter on each attacking creature you control.

Swamp

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Offer Immortality

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Malakir Bloodwitch

Flying, protection from white
When Malakir Bloodwitch enters, each opponent loses life equal to the number of Vampires you control. You gain life equal to the life lost this way.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Blood Curdle

Destroy target creature. Put a menace counter on a creature you control. (It can't be blocked except by two or more creatures.)

Blood Glutton

Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Scion of the Swarm

Flying
Whenever you gain life, put a +1/+1 counter on Scion of the Swarm.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Duskfang Mentor

When Duskfang Mentor enters, put a lifelink counter on target non-Human creature you control.
{1}{B}, {T}: Put a +1/+1 counter on each creature you control with lifelink.

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Dark Bargain

Look at the top three cards of your library. Put two of them into your hand and the other into your graveyard. Dark Bargain deals 2 damage to you.

Blood Operative

Lifelink
When Blood Operative enters, you may exile target card from a graveyard.
Whenever you surveil, if Blood Operative is in your graveyard, you may pay 3 life. If you do, return Blood Operative to your hand.

Bloodvial Purveyor

Flying, trample
Whenever an opponent casts a spell, that player creates a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")
Whenever Bloodvial Purveyor attacks, it gets +1/+0 until end of turn for each Blood token defending player controls.

Painful Lesson

Target player draws two cards and loses 2 life.

Drana, the Last Bloodchief

Flying
Whenever Drana, the Last Bloodchief attacks, defending player chooses a nonlegendary creature card in your graveyard. You return that card to the battlefield with an additional +1/+1 counter on it. The creature is a Vampire in addition to its other types.

Rune-Scarred Demon

Flying
When this creature enters, search your library for a card, put it into your hand, then shuffle.