Emissary of Despair

Flying
Whenever this creature deals combat damage to a player, that player loses 1 life for each artifact they control.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Aurora of Emrakul

Flying, deathtouch
Whenever this creature attacks, each opponent loses 3 life.

Cryptolith Fragment

This artifact enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform this artifact.

Cryptolith Fragment // Aurora of Emrakul

Howling Golem

Whenever this creature attacks or blocks, each player draws a card.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Howling Banshee

Flying
When this creature enters, each player loses 3 life.

Infernal Grasp

Destroy target creature. You lose 2 life.

Howling Mine

At the beginning of each player's draw step, if this artifact is untapped, that player draws an additional card.

Fruit of Tizerus

Target player loses 2 life.
Escape—{3}{B}, Exile three other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Rathi Fiend

When this creature enters, each player loses 3 life.
{3}, {T}: Search your library for a Mercenary permanent card with mana value 3 or less, put it onto the battlefield, then shuffle.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature of their choice.

Thought Vessel

Blood-Toll Harpy

Flying
When this creature enters, each player loses 1 life.

Dire Fleet Ravager

Menace, deathtouch
When this creature enters, each player loses a third of their life, rounded up.

Blood Pact

Target player draws two cards and loses 2 life.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Risky Shortcut

Draw two cards. Each player loses 2 life.

Underworld Dreams

Whenever an opponent draws a card, this enchantment deals 1 damage to that player.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Damnable Pact

Target player draws X cards and loses X life.

Price of Knowledge

Players have no maximum hand size.
At the beginning of each opponent's upkeep, this enchantment deals damage to that player equal to the number of cards in that player's hand.

Temple Bell

Rabid Bloodsucker

Flying (This creature can't be blocked except by creatures with flying or reach.)
When this creature enters, each player loses 2 life.

Skirsdag Supplicant

{B}, {T}, Discard a card: Each player loses 2 life.

Fraying Omnipotence

Each player loses half their life, then discards half the cards in their hand, then sacrifices half the creatures they control of their choice. Round up each time.

Ornithopter of Paradise

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Leaden Myr

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Death Cloud

Each player loses X life, discards X cards, sacrifices X creatures of their choice, then sacrifices X lands of their choice.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Caustic Hound

When this creature dies, each player loses 4 life.

Stronghold Discipline

Each player loses 1 life for each creature they control.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Decanter of Endless Water

You have no maximum hand size.
{T}: Add one mana of any color.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Gilded Lotus

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures of their choice.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Sign in Blood

Soulcage Fiend

When this creature dies, each player loses 3 life.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")

Charcoal Diamond

This artifact enters tapped.
{T}: Add {B}.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Sol Ring

Fell Stinger

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When this creature exploits a creature, target player draws two cards and loses 2 life.

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Coveted Jewel

When this artifact enters, draw three cards.
{T}: Add three mana of any one color.
Whenever one or more creatures an opponent controls attack you and aren't blocked, that player draws three cards and gains control of this artifact. Untap it.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Swamp

Wretched Confluence

Choose three. You may choose the same mode more than once.
• Target player draws a card and loses 1 life.
• Target creature gets -2/-2 until end of turn.
• Return target creature card from your graveyard to your hand.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Deathcurse Ogre

Night's Whisper

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.