Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.

Soothing Balm

Save Life

Choose one —
• Target player gains 2½ life.
• Prevent the next 2½ damage that would be dealt to target creature this turn.
Gotcha — If an opponent says "save" or "life," you may say "Gotcha!" When you do, return Save Life from your graveyard to your hand.

Neglected Manor

This land enters tapped unless a player has 13 or less life.
{T}: Add {W} or {B}.

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Withercrown

Enchant creature
Enchanted creature has base power 0 and has "At the beginning of your upkeep, you lose 1 life unless you sacrifice this creature."

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Temple of Silence

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {W} or {B}.

Dross Harvester

Protection from white
At the beginning of your end step, you lose 4 life.
Whenever a creature dies, you gain 2 life.

Castle Locthwain

This land enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Vampire Lacerator

At the beginning of your upkeep, you lose 1 life unless an opponent has 10 or less life.

Plains

Ambition's Cost

You draw three cards and you lose 3 life.

Reward the Faithful

Any number of target players each gain life equal to the greatest mana value among permanents you control.

Sign in Blood

Target player draws two cards and loses 2 life.

Ebon Drake

Flying
Whenever a player casts a spell, you lose 1 life.

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Measure of Wickedness

At the beginning of your end step, sacrifice this enchantment and you lose 8 life.
Whenever another card is put into your graveyard from anywhere, target opponent gains control of this enchantment.

Treacherous Blessing

When this enchantment enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When this enchantment becomes the target of a spell or ability, sacrifice it.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Scoured Barrens

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {W} or {B}.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Demonic Lore

When this enchantment enters, draw three cards.
At the beginning of your end step, you lose 2 life for each card in your hand.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Life Burst

Target player gains 4 life, then gains 4 life for each card named Life Burst in each graveyard.

Torgaar, Famine Incarnate

As an additional cost to cast this spell, you may sacrifice any number of creatures. This spell costs {2} less to cast for each creature sacrificed this way.
When Torgaar enters, up to one target player's life total becomes half their starting life total, rounded down.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with this creature's toughness.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Forlorn Flats

This land enters tapped.
When this land enters, it deals 1 damage to target opponent.
{T}: Add {W} or {B}.

Aura Extraction

Put target enchantment on top of its owner's library.
Cycling {2} ({2}, Discard this card: Draw a card.)

Congregate

Target player gains 2 life for each creature on the battlefield.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice this land: Draw a card.

Banishment Decree

Put target artifact, creature, or enchantment on top of its owner's library.

Infernal Grasp

Destroy target creature. You lose 2 life.

Disempower

Put target artifact or enchantment on top of its owner's library.

Abyssal Persecutor

Flying, trample
You can't win the game and your opponents can't lose the game.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Swamp

Wall of Shards

Defender, flying
Cumulative upkeep—An opponent gains 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)