Despoil

Destroy target land. Its controller loses 2 life.

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Mardu Shadowspear

Whenever this creature attacks, each opponent loses 1 life.
Dash {1}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Rush of Vitality

Target creature gets +1/+0 and gains lifelink and indestructible until end of turn. (Damage dealt by that creature also causes its controller to gain that much life, and it can't be destroyed by damage or effects that say "destroy.")

Kaya's Ghostform

Enchant creature or planeswalker you control
When enchanted permanent dies or is put into exile, return that card to the battlefield under your control.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Burglar Rat

When this creature enters, each opponent discards a card.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on this enchantment. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if this enchantment has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Liliana's Specter

Flying
When this creature enters, each opponent discards a card.

Vicious Conquistador

Whenever this creature attacks, each opponent loses 1 life.

Stench of Evil

Destroy all Plains. For each land destroyed this way, Stench of Evil deals 1 damage to that land's controller unless they pay {2}.

Creeping Chill

Creeping Chill deals 3 damage to each opponent and you gain 3 life.
When Creeping Chill is put into your graveyard from your library, you may exile it. If you do, Creeping Chill deals 3 damage to each opponent and you gain 3 life.

Elixir of Immortality

{2}, {T}: You gain 5 life. Shuffle this artifact and your graveyard into their owner's library.

Cast Down

Maralen of the Mornsong

Players can't draw cards.
At the beginning of each player's draw step, that player loses 3 life, searches their library for a card, puts it into their hand, then shuffles.

Leyline of the Void

If this card is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Witchbane Orb

When this artifact enters, destroy all Curses attached to you.
You have hexproof. (You can't be the target of spells or abilities your opponents control, including Aura spells.)

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Hired Poisoner

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Spiteful Blow

Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Royal Assassin

Davriel's Shadowfugue

Target player discards two cards and loses 2 life.

Go for the Throat

Sinkhole

Vampire Cutthroat

Skulk (This creature can't be blocked by creatures with greater power.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Darkness

Prevent all combat damage that would be dealt this turn.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Vampire of the Dire Moon

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Hero's Downfall

Grave Pact

Whenever a creature you control dies, each other player sacrifices a creature of their choice.

Doom Blade

Zulaport Cutthroat

Whenever this creature or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Night Market Lookout

Whenever this creature becomes tapped, each opponent loses 1 life and you gain 1 life.

Torment of Scarabs

Enchant player
At the beginning of enchanted player's upkeep, that player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.

Thornbow Archer

Whenever this creature attacks, each opponent who doesn't control an Elf loses 1 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Swamp

Hero's Demise

Pulse Tracker

Darksteel Plate

Indestructible
Equipped creature has indestructible.
Equip {2}

Dark Ritual

Unlikely Aid

Target creature gets +2/+0 and gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Malicious Affliction

Morbid — When you cast this spell, if a creature died this turn, you may copy Malicious Affliction and may choose a new target for the copy.
Destroy target nonblack creature.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Pharika's Chosen

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis.

Toll of the Invasion

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.
Amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)