Rune of Protection: Artifacts

{W}: The next time an artifact source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Runeflare Trap

If an opponent drew three or more cards this turn, you may pay {R} rather than pay this spell's mana cost.
Runeflare Trap deals damage to target player equal to the number of cards in that player's hand.

Niv-Mizzet, Supreme

Flying, hexproof from monocolored
Each instant and sorcery card in your graveyard that's exactly two colors has jump-start. (You may cast that card from your graveyard by discarding a card in addition to paying its other costs. Then exile it.)

Boros Keyrune

{T}: Add {R} or {W}.
{R}{W}: This artifact becomes a 1/1 red and white Soldier artifact creature with double strike until end of turn. (It deals both first-strike and regular combat damage.)

Ferocious Pup

When this creature enters, create a 2/2 green Wolf creature token.

Rune of Protection: White

{W}: The next time a white source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Runesword

{3}, {T}: Target attacking creature gets +2/+0 until end of turn. When that creature leaves the battlefield this turn, sacrifice this artifact. If the creature deals damage to a creature this turn, the creature dealt damage can't be regenerated this turn. If a creature dealt damage by the targeted creature would die this turn, exile that creature instead.

Lone Wolf

You may have this creature assign its combat damage as though it weren't blocked.

Spellrune Howler

Whenever you cast an instant or sorcery spell, this creature gets +2/+2 until end of turn.
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Spellrune Painter

Whenever you cast an instant or sorcery spell, this creature gets +1/+1 until end of turn.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Spellrune Painter // Spellrune Howler

Feral Ridgewolf

Trample
{1}{R}: This creature gets +2/+0 until end of turn.

Furycalm Snarl

As this land enters, you may reveal a Mountain or Plains card from your hand. If you don't, this land enters tapped.
{T}: Add {R} or {W}.

Wall of Runes

Defender (This creature can't attack.)
When this creature enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Shineshadow Snarl

As this land enters, you may reveal a Plains or Swamp card from your hand. If you don't, this land enters tapped.
{T}: Add {W} or {B}.

Sultai Runemark

Enchant creature
Enchanted creature gets +2/+2.
Enchanted creature has deathtouch as long as you control a green or blue permanent. (Any amount of damage it deals to a creature is enough to destroy it.)

Rune of Speed

Enchant permanent
When this Aura enters, draw a card.
As long as enchanted permanent is a creature, it gets +1/+0 and has haste.
As long as enchanted permanent is an Equipment, it has "Equipped creature gets +1/+0 and has haste."

Runes of the Deus

Enchant creature
As long as enchanted creature is red, it gets +1/+1 and has double strike. (It deals both first-strike and regular combat damage.)
As long as enchanted creature is green, it gets +1/+1 and has trample.

Immerwolf

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Each other creature you control that's a Wolf or a Werewolf gets +1/+1.
Non-Human Werewolves you control can't transform.

Sol Ring

Golgari Keyrune

{T}: Add {B} or {G}.
{B}{G}: This artifact becomes a 2/2 black and green Insect artifact creature with deathtouch until end of turn.

Archway Commons

This land enters tapped.
When this land enters, sacrifice it unless you pay {1}.
{T}: Add one mana of any color.

Rakdos Keyrune

{T}: Add {B} or {R}.
{B}{R}: This artifact becomes a 3/1 black and red Devil artifact creature with first strike until end of turn.

Rune of Flight

Enchant permanent
When this Aura enters, draw a card.
As long as enchanted permanent is a creature, it has flying.
As long as enchanted permanent is an Equipment, it has "Equipped creature has flying."

Runebound Wolf

{3}{R}, {T}: This creature deals damage equal to the number of Wolves and Werewolves you control to target opponent.

Marina Vendrell

When Marina Vendrell enters, reveal the top seven cards of your library. Put all enchantment cards from among them into your hand and the rest on the bottom of your library in a random order.
{T}: Lock or unlock a door of target Room you control. Activate only as a sorcery.

Runewing

Flying
When this creature dies, draw a card.

Runeboggle

Counter target spell unless its controller pays {1}.
Draw a card.

Rune-Sealed Wall

Defender
{T}: Surveil 1. (Look at the top card of your library. You may put it into your graveyard.)

Hungry Ridgewolf

As long as you control another Wolf or Werewolf, this creature gets +1/+0 and has trample.

Annul

Counter target artifact or enchantment spell.

Orzhov Keyrune

{T}: Add {W} or {B}.
{W}{B}: This artifact becomes a 1/4 white and black Thrull artifact creature with lifelink until end of turn.

Island

Abzan Runemark

Enchant creature
Enchanted creature gets +2/+2.
Enchanted creature has vigilance as long as you control a black or green permanent.

Rune of Mortality

Enchant permanent
When this Aura enters, draw a card.
As long as enchanted permanent is a creature, it has deathtouch.
As long as enchanted permanent is an Equipment, it has "Equipped creature has deathtouch."

Temur Runemark

Enchant creature
Enchanted creature gets +2/+2.
Enchanted creature has trample as long as you control a blue or red permanent.

Jeskai Runemark

Enchant creature
Enchanted creature gets +2/+2.
Enchanted creature has flying as long as you control a red or white permanent.

Rune-Cervin Rider

Flying
{G/W}{G/W}: This creature gets +1/+1 until end of turn.

Necroblossom Snarl

As this land enters, you may reveal a Swamp or Forest card from your hand. If you don't, this land enters tapped.
{T}: Add {B} or {G}.

Path of Ancestry

This land enters tapped.
{T}: Add one mana of any color in your commander's color identity. When that mana is spent to cast a creature spell that shares a creature type with your commander, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Rune of Protection: Green

{W}: The next time a green source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Mardu Runemark

Enchant creature
Enchanted creature gets +2/+2.
Enchanted creature has first strike as long as you control a white or black permanent.

Rukarumel, Biologist

As Rukarumel enters, choose a creature type.
Slivers you control and nontoken creatures you control are the chosen type in addition to their other creature types. The same is true for creature spells you control and creature cards you own that aren't on the battlefield.
{3}, {T}: Create a 1/1 colorless Sliver creature token.

Hall of Tagsin

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
{4}, {T}: Create a tapped Powerstone token. (It's an artifact with "{T}: Add {C}. This mana can't be spent to cast a nonartifact spell.")

Hargilde, Kindly Runechanter

{T}: Add {C}{C}. Spend this mana only to cast artifact spells or activate abilities of artifacts.
Friends forever (You can have two commanders if both have friends forever.)

Runed Halo

As this enchantment enters, choose a card name.
You have protection from the chosen card name. (You can't be targeted, dealt damage, or enchanted by anything with that name.)

Runed Stalactite

Equipped creature gets +1/+1 and is every creature type.
Equip {2}

Simic Keyrune

{T}: Add {G} or {U}.
{G}{U}: This artifact becomes a 2/3 green and blue Crab artifact creature with hexproof until end of turn. (It can't be the target of spells or abilities your opponents control.)

Swamp

Law-Rune Enforcer

{1}, {T}: Tap target creature with mana value 2 or greater.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Kenrith, the Returned King

{R}: All creatures gain trample and haste until end of turn.
{1}{G}: Put a +1/+1 counter on target creature.
{2}{W}: Target player gains 5 life.
{3}{U}: Target player draws a card.
{4}{B}: Put target creature card from a graveyard onto the battlefield under its owner's control.

Rune of Might

Enchant permanent
When this Aura enters, draw a card.
As long as enchanted permanent is a creature, it gets +1/+1 and has trample.
As long as enchanted permanent is an Equipment, it has "Equipped creature gets +1/+1 and has trample."

Weathered Runestone

Nonland permanent cards in graveyards and libraries can't enter the battlefield.
Players can't cast spells from graveyards or libraries.

Rune of Sustenance

Enchant permanent
When this Aura enters, draw a card.
As long as enchanted permanent is a creature, it has lifelink.
As long as enchanted permanent is an Equipment, it has "Equipped creature has lifelink."

Runeclaw Bear

Frostboil Snarl

As this land enters, you may reveal an Island or Mountain card from your hand. If you don't, this land enters tapped.
{T}: Add {U} or {R}.

Runed Servitor

When this creature dies, each player draws a card.

Deranged Whelp

Menace (This creature can't be blocked except by two or more creatures.)

Inga Rune-Eyes

When Inga Rune-Eyes enters, scry 3.
When Inga Rune-Eyes dies, draw three cards if three or more creatures died this turn.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Raised by Wolves

Enchant creature
When this Aura enters, create two 2/2 green Wolf creature tokens.
Enchanted creature gets +1/+1 for each Wolf you control.

Rune of Protection: Blue

{W}: The next time a blue source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Runehorn Hellkite

Flying
{5}{R}, Exile this card from your graveyard: Each player discards their hand, then draws seven cards.

Azorius Keyrune

{T}: Add {W} or {U}.
{W}{U}: This artifact becomes a 2/2 white and blue Bird artifact creature with flying until end of turn.

Niv-Mizzet, Guildpact

Flying, hexproof from multicolored
Whenever Niv-Mizzet deals combat damage to a player, it deals X damage to any target, target player draws X cards, and you gain X life, where X is the number of different color pairs among permanents you control that are exactly two colors.

Rune of Protection: Black

{W}: The next time a black source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Opal Palace

{T}: Add {C}.
{1}, {T}: Add one mana of any color in your commander's color identity. If you spend this mana to cast your commander, it enters with a number of additional +1/+1 counters on it equal to the number of times it's been cast from the command zone this game.

Rune of Protection: Red

{W}: The next time a red source of your choice would deal damage to you this turn, prevent that damage.
Cycling {2} ({2}, Discard this card: Draw a card.)

Runeforge Champion

When this creature enters, you may search your library and/or graveyard for a Rune card, reveal it, and put it into your hand. If you search your library this way, shuffle.
You may pay {1} rather than pay the mana cost for Rune spells you cast.

Rune Snag

Counter target spell unless its controller pays {2} plus an additional {2} for each card named Rune Snag in each graveyard.

Vineglimmer Snarl

As this land enters, you may reveal a Forest or Island card from your hand. If you don't, this land enters tapped.
{T}: Add {G} or {U}.

Weed-Pruner Poplar

At the beginning of your upkeep, target creature other than this creature gets -1/-1 until end of turn.

Izzet Keyrune

{T}: Add {U} or {R}.
{U}{R}: Until end of turn, this artifact becomes a 2/1 blue and red Elemental artifact creature.
Whenever this artifact deals combat damage to a player, you may draw a card. If you do, discard a card.

Selesnya Keyrune

{T}: Add {G} or {W}.
{G}{W}: This artifact becomes a 3/3 green and white Wolf artifact creature until end of turn.

Runechanter's Pike

Equipped creature has first strike and gets +X/+0, where X is the number of instant and sorcery cards in your graveyard.
Equip {2}

Banishing Light

When this enchantment enters, exile target nonland permanent an opponent controls until this enchantment leaves the battlefield.

Mountain

Havengul Runebinder

{2}{U}, {T}, Exile a creature card from your graveyard: Create a 2/2 black Zombie creature token, then put a +1/+1 counter on each Zombie creature you control.

Dimir Keyrune

{T}: Add {U} or {B}.
{U}{B}: This artifact becomes a 2/2 blue and black Horror artifact creature until end of turn and can't be blocked this turn.

All That Glitters

Enchant creature
Enchanted creature gets +1/+1 for each artifact and/or enchantment you control.

Arcane Signet

Plains

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Gruul Keyrune

{T}: Add {R} or {G}.
{R}{G}: This artifact becomes a 3/2 red and green Beast artifact creature with trample until end of turn.

Runed Crown

When this Equipment enters, you may search your library, hand, and/or graveyard for a Rune card and put it onto the battlefield attached to this Equipment. If you search your library this way, shuffle.
Equipped creature gets +1/+1.
Equip {2}

Fearless Pup

First strike
Boast — {2}{R}: This creature gets +2/+0 until end of turn. (Activate only if this creature attacked this turn and only once each turn.)