Mister Negative

Vigilance, lifelink
Darkforce Inversion — When Mister Negative enters, you may exchange life totals with target opponent. If you lose life this way, draw that many cards.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: This artifact deals 50 damage to any target.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. This artifact deals 1 damage to you.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Evra, Halcyon Witness

Lifelink
{4}: Exchange your life total with Evra's power.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Dark Ritual

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Sol Ring

Isolated Chapel

This land enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice this land: Draw a card.

Gideon, the Oathsworn

Whenever you attack with two or more non-Gideon creatures, put a +1/+1 counter on each of those creatures.
+2: Until end of turn, Gideon becomes a 5/5 white Soldier creature that's still a planeswalker. Prevent all damage that would be dealt to him this turn. (He can't attack if he was cast this turn.)
−9: Exile Gideon and each creature your opponents control.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Tainted Sigil

{T}, Sacrifice this artifact: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Pact Weapon

As long as this Equipment is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with this creature's toughness.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Gideon, Champion of Justice

+1: Put a loyalty counter on Gideon for each creature target opponent controls.
0: Until end of turn, Gideon becomes a Human Soldier creature with power and toughness each equal to the number of loyalty counters on him and gains indestructible. He's still a planeswalker. Prevent all damage that would be dealt to him this turn.
−15: Exile all other permanents.

Death's Shadow

This creature gets -X/-X, where X is your life total.

Desolate Mire

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Sign in Blood

Target player draws two cards and loses 2 life.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Blazing Hope

Exile target creature with power greater than or equal to your life total.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Cloudkill

All creatures get -X/-X until end of turn, where X is the greatest mana value of a commander you own on the battlefield or in the command zone.

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Cecil, Redeemed Paladin

Lifelink
Protect — Whenever Cecil attacks, other attacking creatures gain indestructible until end of turn.

Cecil, Dark Knight

Deathtouch
Darkness — Whenever Cecil deals damage, you lose that much life. Then if your life total is less than or equal to half your starting life total, untap Cecil and transform it.

Cecil, Dark Knight // Cecil, Redeemed Paladin

Tymna the Weaver

Lifelink
At the beginning of each of your postcombat main phases, you may pay X life, where X is the number of opponents that were dealt combat damage this turn. If you do, draw X cards.
Partner (You can have two commanders if both have partner.)

Memory of Toshiro

{T}, Pay 1 life: Add {B}. Spend this mana only to cast an instant or sorcery spell.

Life of Toshiro Umezawa

(As this Saga enters and after your draw step, add a lore counter.)
I, II — Choose one —
• Target creature gets +2/+2 until end of turn.
• Target creature gets -1/-1 until end of turn.
• You gain 2 life.
III — Exile this Saga, then return it to the battlefield transformed under your control.

Life of Toshiro Umezawa // Memory of Toshiro

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Gideon of the Trials

+1: Until your next turn, prevent all damage target permanent would deal.
0: Until end of turn, Gideon becomes a 4/4 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: You get an emblem with "As long as you control a Gideon planeswalker, you can't lose the game and your opponents can't win the game."

Lich

As this enchantment enters, you lose life equal to your life total.
You don't lose the game for having 0 or less life.
If you would gain life, draw that many cards instead.
Whenever you're dealt damage, sacrifice that many nontoken permanents. If you can't, you lose the game.
When this enchantment is put into a graveyard from the battlefield, you lose the game.

Shattered Sanctum

This land enters tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform this artifact.

Chalice of Life // Chalice of Death

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Bleachbone Verge

{T}: Add {B}.
{T}: Add {W}. Activate only if you control a Plains or a Swamp.

Gideon, Ally of Zendikar

+1: Until end of turn, Gideon becomes a 5/5 Human Soldier Ally creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: Create a 2/2 white Knight Ally creature token.
−4: You get an emblem with "Creatures you control get +1/+1."

Gideon Jura

+2: During target opponent's next turn, creatures that player controls attack Gideon Jura if able.
−2: Destroy target tapped creature.
0: Until end of turn, Gideon Jura becomes a 6/6 Human Soldier creature that's still a planeswalker. Prevent all damage that would be dealt to him this turn.

The Last Ride

The Last Ride gets -X/-X, where X is your life total.
{2}{B}, Pay 2 life: Draw a card.
Crew 2

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Shineshadow Snarl

As this land enters, you may reveal a Plains or Swamp card from your hand. If you don't, this land enters tapped.
{T}: Add {W} or {B}.

Night's Whisper

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Vault of Champions

This land enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Gideon Blackblade

During your turn, Gideon Blackblade is a 4/4 Human Soldier creature with indestructible that's still a planeswalker.
Prevent all damage that would be dealt to Gideon Blackblade during your turn.
+1: Up to one other target creature you control gains your choice of vigilance, lifelink, or indestructible until end of turn.
−6: Exile target nonland permanent.

Arcane Signet

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Sorin, Grim Nemesis

+1: Reveal the top card of your library and put that card into your hand. Each opponent loses life equal to its mana value.
−X: Sorin deals X damage to target creature or planeswalker and you gain X life.
−9: Create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the highest life total among all players.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Scrubland

Grimclimb Pathway

Brightclimb Pathway

Brightclimb Pathway // Grimclimb Pathway

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Serra the Benevolent

+2: Creatures you control with flying get +1/+1 until end of turn.
−3: Create a 4/4 white Angel creature token with flying and vigilance.
−6: You get an emblem with "If you control a creature, damage that would reduce your life total to less than 1 reduces it to 1 instead."

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Lich's Mirror

If you would lose the game, instead shuffle your hand, your graveyard, and all permanents you own into your library, then draw seven cards and your life total becomes 20.

Swamp

Ancient Tomb

{T}: Add {C}{C}. This land deals 2 damage to you.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Plains

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Gideon, Martial Paragon

+2: Untap all creatures you control. Those creatures get +1/+1 until end of turn.
0: Until end of turn, Gideon becomes a 5/5 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
−10: Creatures you control get +2/+2 until end of turn. Tap all creatures your opponents control.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Tivash, Gloom Summoner

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay X life, where X is the amount of life you gained this turn. If you do, create an X/X black Demon creature token with flying.

Platinum Emperion

Your life total can't change. (You can't gain or lose life. You can't pay any amount of life except 0.)