Go for the Throat

Alien Symbiosis

Enchant creature
Enchanted creature gets +1/+1, has menace, and is a Symbiote in addition to its other types.
You may cast this card from your graveyard by discarding a card in addition to paying its other costs.

Spider-Bot

Reach
When this creature enters, you may search your library for a basic land card, reveal it, then shuffle and put that card on top.

Spider-Man No More

Enchant creature
Enchanted creature is a Citizen with base power and toughness 1/1. It has defender and loses all other abilities. (It also loses all other creature types.)

Prison Break

Return target creature card from your graveyard to the battlefield with an additional +1/+1 counter on it.
Mayhem {3}{B} (You may cast this card from your graveyard for {3}{B} if you discarded it this turn. Timing rules still apply.)

Whoosh!

Kicker {1}{U} (You may pay an additional {1}{U} as you cast this spell.)
Return target nonland permanent to its owner's hand. If this spell was kicked, draw a card.

Multiversal Passage

As this land enters, choose a basic land type. Then you may pay 2 life. If you don't, it enters tapped.
This land is the chosen type.

Peter Parker's Camera

This artifact enters with three film counters on it.
{2}, {T}, Remove a film counter from this artifact: Copy target activated or triggered ability you control. You may choose new targets for the copy.

Passenger Ferry

Whenever this Vehicle attacks, you may pay {U}. When you do, another target attacking creature can't be blocked this turn.
Crew 2 (Tap any number of creatures you control with total power 2 or more: This Vehicle becomes an artifact creature until end of turn.)

Beetle, Legacy Criminal

Flying
{1}{U}, Exile this card from your graveyard: Put a +1/+1 counter on target creature. It gains flying until end of turn. Activate only as a sorcery.

The Soul Stone

Indestructible
{T}: Add {B}.
{6}{B}, {T}, Exile a creature you control: Harness The Soul Stone. (Once harnessed, its ∞ ability is active.)
∞ — At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

The Death of Gwen Stacy

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Destroy target creature.
II — Each player may discard a card. Each player who doesn't loses 3 life.
III — Exile any number of target players' graveyards.

Vibrant Cityscape

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Flying Octobot

Flying
Whenever another Villain you control enters, put a +1/+1 counter on this creature. This ability triggers only once each turn.

Spider-Man Noir

Menace
Whenever a creature you control attacks alone, put a +1/+1 counter on it. Then surveil X, where X is the number of counters on it. (Look at the top X cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Behold the Sinister Six!

Return up to six target creature cards with different names from your graveyard to the battlefield.

Morlun, Devourer of Spiders

Lifelink
Morlun enters with X +1/+1 counters on him.
When Morlun enters, he deals X damage to target opponent.

Island

Doctor Octopus, Master Planner

Other Villains you control get +2/+2.
Your maximum hand size is eight.
At the beginning of your end step, if you have fewer than eight cards in hand, draw cards equal to the difference.

Venom, Evil Unleashed

Deathtouch
{2}{B}, Exile this card from your graveyard: Put two +1/+1 counters on target creature. It gains deathtouch until end of turn. Activate only as a sorcery.

Future Flight

Enchant creature
When this Aura enters, draw two cards.
Enchanted creature gets +2/+0 and has flying. (It can't be blocked except by creatures with flying or reach.)

Doc Ock's Tentacles

Whenever a creature you control with mana value 5 or greater enters, you may attach this Equipment to it.
Equipped creature gets +4/+4.
Equip {5}

Hydro-Man, Fluid Felon

Whenever you cast a blue spell, if Hydro-Man is a creature, he gets +1/+1 until end of turn.
At the beginning of your end step, untap Hydro-Man. Until your next turn, he becomes a land and gains "{T}: Add {U}." (He's not a creature during that time.)

Merciless Enforcers

Lifelink
{3}{B}: This creature deals 1 damage to each opponent.

Sol Ring

Robotics Mastery

Flash
Enchant creature
When this Aura enters, create two 1/1 colorless Robot artifact creature tokens with flying.
Enchanted creature gets +2/+2.

Venom's Hunger

This spell costs {2} less to cast if you control a Villain.
Destroy target creature. You gain 2 life.

Spider-Man 2099, Miguel O'Hara

When Spider-Man 2099 enters, return up to one target creature to its owner's hand.
Whenever one or more creatures you control deal combat damage to a player, draw a card.

Swamp

Tombstone, Career Criminal

When Tombstone enters, return target Villain card from your graveyard to your hand.
Villain spells you cast cost {1} less to cast.

Mysterio, Master of Illusion

When Mysterio enters, create a 3/3 blue Illusion Villain creature token for each nontoken Villain you control. Exile those tokens when Mysterio leaves the battlefield.

Morbius the Living Vampire

Flying, vigilance, lifelink
{U}{B}, Exile this card from your graveyard: Look at the top three cards of your library. Put one of them into your hand and the rest on the bottom of your library in any order.

Chameleon, Master of Disguise

You may have Chameleon enter as a copy of a creature you control, except his name is Chameleon, Master of Disguise.
Mayhem {2}{U} (You may cast this card from your graveyard for {2}{U} if you discarded it this turn. Timing rules still apply.)

Symbiote Spider-Man

Whenever this creature deals combat damage to a player, look at that many cards from the top of your library. Put one of them into your hand and the rest into your graveyard.
Find New Host — {2}{U/B}, Exile this card from your graveyard: Put a +1/+1 counter on target creature you control. It gains this card's other abilities. Activate only as a sorcery.

Sinister Hideout

This land enters tapped.
{T}: Add {U} or {B}.
{4}, {T}: Surveil 1. (Look at the top card of your library. You may put it into your graveyard.)

Mechanical Mobster

When this creature enters, exile up to one target card from a graveyard. Target creature you control connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on that creature.)

Rocket-Powered Goblin Glider

When this Equipment enters, if it was cast from your graveyard, attach it to target creature you control.
Equipped creature gets +2/+0 and has flying and haste.
Equip {2}
Mayhem {2}

Scorpion's Sting

Target creature gets -3/-3 until end of turn.

Iron Spider, Stark Upgrade

Vigilance
{T}: Put a +1/+1 counter on each artifact creature and/or Vehicle you control.
{2}, Remove two +1/+1 counters from among artifacts you control: Draw a card.

Hot Dog Cart

When this artifact enters, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
{T}: Add one mana of any color.

Lady Octopus, Inspired Inventor

Whenever you draw your first or second card each turn, put an ingenuity counter on Lady Octopus.
{T}: You may cast an artifact spell from your hand with mana value less than or equal to the number of ingenuity counters on Lady Octopus without paying its mana cost.

Parker Luck

At the beginning of your end step, two target players each reveal the top card of their library. They each lose life equal to the mana value of the card revealed by the other player. Then they each put the card they revealed into their hand.

Prowler, Clawed Thief

Menace (This creature can't be blocked except by two or more creatures.)
Whenever another Villain you control enters, Prowler connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)

Damnation

Destroy all creatures. They can't be regenerated.

Venom, Eddie Brock

Menace (This creature can't be blocked except by two or more creatures.)
Whenever another creature dies, put a +1/+1 counter on Venom. If that creature was a Villain, draw a card.

Sandman's Quicksand

Mayhem {3}{B} (You may cast this card from your graveyard for {3}{B} if you discarded it this turn. Timing rules still apply.)
All creatures get -2/-2 until end of turn. If this spell's mayhem cost was paid, creatures your opponents control get -2/-2 until end of turn instead.

Dark Ritual

Alchemax Slayer-Bots

When this creature enters, tap target creature an opponent controls and put a stun counter on it. (If a permanent with a stun counter would become untapped, remove one from it instead.)

School Daze

Choose one —
• Do Homework — Draw three cards.
• Fight Crime — Counter target spell. Draw a card.

Grendel, Spawn of Knull

Flying (This creature can't be blocked except by creatures with flying or reach.)
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

The Clone Saga

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Surveil 3.
II — When you next cast a creature spell this turn, copy it, except the copy isn't legendary.
III — Choose a card name. Whenever a creature with the chosen name deals combat damage to a player this turn, draw a card.

Lethal Protection

Destroy target creature. Return up to one target creature card from your graveyard to your hand.

Impostor Syndrome

Whenever a nontoken creature you control deals combat damage to a player, create a token that's a copy of it, except it isn't legendary.

Vulture, Scheming Scavenger

Flying
Whenever Vulture attacks, other Villains you control gain flying until end of turn.

Amazing Acrobatics

Choose one or both —
• Counter target spell.
• Tap one or two target creatures.

Spider-Byte, Web Warden

When Spider-Byte enters, return up to one target nonland permanent to its owner's hand.

Superior Spider-Man

Mind Swap — You may have Superior Spider-Man enter as a copy of any creature card in a graveyard, except his name is Superior Spider-Man and he's a 4/4 Spider Human Hero in addition to his other types. When you do, exile that card.

Tendrils of Agony

Target player loses 2 life and you gain 2 life.
Storm (When you cast this spell, copy it for each spell cast before it this turn. You may choose new targets for the copies.)

Lyla, Holographic Assistant

Whenever you draw a card, put a +1/+1 counter on target creature.

Risky Research

Surveil 2, then draw two cards. You lose 2 life. (To surveil 2, look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Spider-Sense

Web-slinging {U} (You may cast this spell for {U} if you also return a tapped creature you control to its owner's hand.)
Counter target instant spell, sorcery spell, or triggered ability.

Gwenom, Remorseless

Deathtouch, lifelink
Whenever Gwenom attacks, until end of turn you may look at the top card of your library any time and you may play cards from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.

The Spot's Portal

Put target creature on the bottom of its owner's library. You lose 2 life unless you control a Villain.

Agent Venom

Flash
Menace
Whenever another nontoken creature you control dies, you draw a card and lose 1 life.

Scorpion, Seething Striker

Deathtouch
At the beginning of your end step, if a creature died this turn, target creature you control connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on that creature.)

Common Crook

When this creature dies, create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Symbiote Spawn

When this creature dies, each opponent loses 2 life and you gain 2 life.

Daily Bugle Building

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
Smear Campaign — {1}, {T}: Target legendary creature gains menace until end of turn. Activate only as a sorcery.

Hide on the Ceiling

Exile X target artifacts and/or creatures. Return the exiled cards to the battlefield under their owners' control at the beginning of the next end step.

Doc Ock's Henchmen

Flash
Whenever this creature attacks, it connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)