Risky Research

Surveil 2, then draw two cards. You lose 2 life. (To surveil 2, look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Lorthos, the Tidemaker

Whenever Lorthos attacks, you may pay {8}. If you do, tap up to eight target permanents. Those permanents don't untap during their controllers' next untap steps.

Villainous Wrath

Target opponent loses life equal to the number of creatures they control. Then destroy all creatures.

Counterspell

Doc Ock, Sinister Scientist

As long as there are eight or more cards in your graveyard, Doc Ock has base power and toughness 8/8.
As long as you control another Villain, Doc Ock has hexproof. (He can't be the target of spells or abilities your opponents control.)

Superior Spider-Man

Mind Swap — You may have Superior Spider-Man enter as a copy of any creature card in a graveyard, except his name is Superior Spider-Man and he's a 4/4 Spider Human Hero in addition to his other types. When you do, exile that card.

Doctor Octopus, Master Planner

Other Villains you control get +2/+2.
Your maximum hand size is eight.
At the beginning of your end step, if you have fewer than eight cards in hand, draw cards equal to the difference.

Grasping Tentacles

Target opponent mills eight cards. You may put an artifact card from that player's graveyard onto the battlefield under your control.

Behold the Sinister Six!

Return up to six target creature cards with different names from your graveyard to the battlefield.

Lady Octopus, Inspired Inventor

Whenever you draw your first or second card each turn, put an ingenuity counter on Lady Octopus.
{T}: You may cast an artifact spell from your hand with mana value less than or equal to the number of ingenuity counters on Lady Octopus without paying its mana cost.

Doc Ock's Henchmen

Flash
Whenever this creature attacks, it connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)

Doc Ock, Evil Inventor

At the beginning of combat on your turn, target noncreature artifact you control becomes an 8/8 Robot Villain artifact creature in addition to its other types.

Flying Octobot

Flying
Whenever another Villain you control enters, put a +1/+1 counter on this creature. This ability triggers only once each turn.