Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Leyline of Punishment

If this card is in your opening hand, you may begin the game with it on the battlefield.
Players can't gain life.
Damage can't be prevented.

Forsaken Wastes

Players can't gain life.
At the beginning of each player's upkeep, that player loses 1 life.
Whenever this enchantment becomes the target of a spell, that spell's controller loses 5 life.

Flames of the Blood Hand

Flames of the Blood Hand deals 4 damage to target player or planeswalker. The damage can't be prevented. If that player or that planeswalker's controller would gain life this turn, that player gains no life instead.

Everlasting Torment

Players can't gain life.
Damage can't be prevented.
All damage is dealt as though its source had wither. (A source with wither deals damage to creatures in the form of -1/-1 counters.)

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Quakebringer

Your opponents can't gain life.
At the beginning of your upkeep, Quakebringer deals 2 damage to each opponent. This ability triggers only if Quakebringer is on the battlefield or if Quakebringer is in your graveyard and you control a Giant.
Foretell {2}{R}{R}

Gríma Wormtongue

Your opponents can't gain life.
{T}, Sacrifice another creature: Target player loses 1 life. If the sacrificed creature was legendary, amass Orcs 2.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Call In a Professional

Players can't gain life this turn. Damage can't be prevented this turn. Call In a Professional deals 3 damage to any target. (Shield counters don't prevent this damage as they're removed.)

Witch Hunt

Players can't gain life.
At the beginning of your upkeep, this enchantment deals 4 damage to you.
At the beginning of your end step, target opponent chosen at random gains control of this enchantment.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Sunspine Lynx

Players can't gain life.
Damage can't be prevented.
When this creature enters, it deals damage to each player equal to the number of nonbasic lands that player controls.

Screaming Nemesis

Haste
Whenever this creature is dealt damage, it deals that much damage to any other target. If a player is dealt damage this way, they can't gain life for the rest of the game.

Tibalt, Rakish Instigator

Your opponents can't gain life.
−2: Create a 1/1 red Devil creature token with "When this token dies, it deals 1 damage to any target."

Giant Cindermaw

Trample (This creature can deal excess combat damage to the player or planeswalker it's attacking.)
Players can't gain life.

Stigma Lasher

Wither (This deals damage to creatures in the form of -1/-1 counters.)
Whenever this creature deals damage to a player, that player can't gain life for the rest of the game.

Skullcrack

Players can't gain life this turn. Damage can't be prevented this turn. Skullcrack deals 3 damage to target player or planeswalker.

The Lord of Pain

Menace
Your opponents can't gain life.
Whenever a player casts their first spell each turn, choose another target player. The Lord of Pain deals damage equal to that spell's mana value to the chosen player.

Knight of Dusk's Shadow

Menace (This creature can't be blocked except by two or more creatures.)
Your opponents can't gain life.
{1}{B}: This creature gets +1/+1 until end of turn.

Sulfuric Vortex

At the beginning of each player's upkeep, this enchantment deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Roiling Vortex

At the beginning of each player's upkeep, this enchantment deals 1 damage to them.
Whenever a player casts a spell, if no mana was spent to cast that spell, this enchantment deals 5 damage to that player.
{R}: Your opponents can't gain life this turn.

Grievous Wound

Enchant player
Enchanted player can't gain life.
Whenever enchanted player is dealt damage, they lose half their life, rounded up.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, this creature deals 1 damage to that creature's controller.