Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Phyrexian Crusader

First strike, protection from red and from white
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Raven's Crime

Target player discards a card.
Retrace (You may cast this card from your graveyard by discarding a land card in addition to paying its other costs.)

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Tormod's Crypt

{T}, Sacrifice Tormod's Crypt: Exile target player's graveyard.

Mind Shatter

Target player discards X cards at random.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Break the Ice

Destroy target land that is snow or could produce {C}.
Overload {4}{B}{B} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Inscription of Ruin

Kicker {2}{B}{B}
Choose one. If this spell was kicked, choose any number instead.
• Target opponent discards two cards.
• Return target creature card with mana value 2 or less from your graveyard to the battlefield.
• Destroy target creature with mana value 3 or less.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Cast Down

Gurmag Angler

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Whispers of Emrakul

Target opponent discards a card at random.
Delirium — If there are four or more card types among cards in your graveyard, that player discards two cards at random instead.

The Rack

As The Rack enters, choose an opponent.
At the beginning of the chosen player's upkeep, The Rack deals X damage to that player, where X is 3 minus the number of cards in their hand.