Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Phyrexian Scuta

Kicker—Pay 3 life. (You may pay 3 life in addition to any other costs as you cast this spell.)
If this creature was kicked, it enters with two +1/+1 counters on it.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

Inkshield

Prevent all combat damage that would be dealt to you this turn. For each 1 damage prevented this way, create a 2/1 white and black Inkling creature token with flying.

Mister Negative

Vigilance, lifelink
Darkforce Inversion — When Mister Negative enters, you may exchange life totals with target opponent. If you lose life this way, draw that many cards.

Phyrexian Processor

As this artifact enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as this artifact entered.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Dire Tactics

Exile target creature. If you don't control a Human, you lose life equal to that creature's toughness.

Skrelv's Hive

At the beginning of your upkeep, you lose 1 life and create a 1/1 colorless Phyrexian Mite artifact creature token with toxic 1 and "This token can't block."
Corrupted — As long as an opponent has three or more poison counters, creatures you control with toxic have lifelink.

Lord Skitter's Blessing

When this enchantment enters, create a Wicked Role token attached to target creature you control. (Enchanted creature gets +1/+1. When this token is put into a graveyard, each opponent loses 1 life.)
At the beginning of your draw step, if you control an enchanted creature, you lose 1 life and you draw an additional card.

Swamp

Zero Point Ballad

Destroy all creatures with toughness X or less. You lose X life. If X is 6 or more, return a creature card put into a graveyard this way to the battlefield under your control.

Castle Locthwain

This land enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Breena, the Demagogue

Flying
Whenever a player attacks one of your opponents, if that opponent has more life than another of your opponents, that attacking player draws a card and you put two +1/+1 counters on a creature you control.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.

Vona, Butcher of Magan

Vigilance, lifelink
{T}, Pay 7 life: Destroy target nonland permanent. Activate only during your turn.

Orzhov Signet

Infernal Contract

Draw four cards. You lose half your life, rounded up.

Priest of Fell Rites

{T}, Pay 3 life, Sacrifice this creature: Return target creature card from your graveyard to the battlefield. Activate only as a sorcery.
Unearth {3}{W}{B} ({3}{W}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Infernal Grasp

Destroy target creature. You lose 2 life.

Children of Korlis

Sacrifice this creature: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Dark Knight's Greatsword

Job select (When this Equipment enters, create a 1/1 colorless Hero creature token, then attach this to it.)
Equipped creature gets +3/+0 and is a Knight in addition to its other types.
Chaosbringer — Equip—Pay 3 life. Activate only once each turn.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Malakir Mire

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Desolate Mire

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Orzhov Basilica

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Sol Ring

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Arcane Signet

Valgavoth, Terror Eater

Flying, lifelink
Ward—Sacrifice three nonland permanents.
If a card you didn't control would be put into an opponent's graveyard from anywhere, exile it instead.
During your turn, you may play cards exiled with Valgavoth. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.

Meathook Massacre II

When Meathook Massacre II enters, each player sacrifices X creatures of their choice.
Whenever a creature you control dies, you may pay 3 life. If you do, return that card under your control with a finality counter on it.
Whenever a creature an opponent controls dies, they may pay 3 life. If they don't, return that card under your control with a finality counter on it.

Final Payment

As an additional cost to cast this spell, pay 5 life or sacrifice a creature or enchantment.
Destroy target creature.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. This artifact deals 1 damage to you.

Cecil, Redeemed Paladin

Lifelink
Protect — Whenever Cecil attacks, other attacking creatures gain indestructible until end of turn.

Cecil, Dark Knight

Deathtouch
Darkness — Whenever Cecil deals damage, you lose that much life. Then if your life total is less than or equal to half your starting life total, untap Cecil and transform it.

Cecil, Dark Knight // Cecil, Redeemed Paladin

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap this artifact.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice this land: Draw a card.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Pact Weapon

As long as this Equipment is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Street Wraith

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
Cycling—Pay 2 life. (Pay 2 life, Discard this card: Draw a card.)

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Phyrexian Colossus

This creature doesn't untap during your untap step.
Pay 8 life: Untap this creature.
This creature can't be blocked except by three or more creatures.

Rain of Daggers

Destroy all creatures target opponent controls. You lose 2 life for each creature destroyed this way.

Dark Ritual

Temple of Silence

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {W} or {B}.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Myr Convert

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
{T}, Pay 2 life: Add one mana of any color.

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Fell Mire

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.