Mind's Dilation

Whenever an opponent casts their first spell each turn, that player exiles the top card of their library. If it's a nonland card, you may cast it without paying its mana cost.

Hunting Grounds

Threshold — As long as there are seven or more cards in your graveyard, this enchantment has "Whenever an opponent casts a spell, you may put a creature card from your hand onto the battlefield."

Counterbalance

Whenever an opponent casts a spell, you may reveal the top card of your library. If you do, counter that spell if it has the same mana value as the revealed card.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Kraum, Ludevic's Opus

Flying, haste
Whenever an opponent casts their second spell each turn, draw a card.
Partner (You can have two commanders if both have partner.)

Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Mystic Remora

Cumulative upkeep {1} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
Whenever an opponent casts a noncreature spell, you may draw a card unless that player pays {4}.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Eyes of the Wisent

Whenever an opponent casts a blue spell during your turn, you may create a 4/4 green Elemental creature token.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek deals damage equal to that spell's mana value to any target.

Dragonlair Spider

Reach
Whenever an opponent casts a spell, create a 1/1 green Insect creature token.

Pain Distributor

Menace
Whenever a player casts their first spell each turn, they create a Treasure token.
Whenever an artifact an opponent controls is put into a graveyard from the battlefield, this creature deals 1 damage to that player.

Shadow in the Warp

The first creature spell you cast each turn costs {2} less to cast.
Whenever an opponent casts their first noncreature spell each turn, this enchantment deals 2 damage to that player.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Lurking Predators

Whenever an opponent casts a spell, reveal the top card of your library. If it's a creature card, put it onto the battlefield. Otherwise, you may put that card on the bottom of your library.

The Lord of Pain

Menace
Your opponents can't gain life.
Whenever a player casts their first spell each turn, choose another target player. The Lord of Pain deals damage equal to that spell's mana value to the chosen player.

Scab-Clan Berserker

Haste
Renown 1 (When this creature deals combat damage to a player, if it isn't renowned, put a +1/+1 counter on it and it becomes renowned.)
Whenever an opponent casts a noncreature spell, if this creature is renowned, this creature deals 2 damage to that player.

Talion, the Kindly Lord

Flying
As Talion enters, choose a number between 1 and 10.
Whenever an opponent casts a spell with mana value, power, or toughness equal to the chosen number, that player loses 2 life and you draw a card.

Ishai, Ojutai Dragonspeaker

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Ishai.
Partner (You can have two commanders if both have partner.)

Howling Moon

At the beginning of combat on your turn, target Wolf or Werewolf you control gets +2/+2 until end of turn.
Whenever an opponent casts their second spell each turn, create a 2/2 green Wolf creature token.

Infested Roothold

Defender (This creature can't attack.)
Protection from artifacts
Whenever an opponent casts an artifact spell, you may create a 1/1 green Insect creature token.

Ghostly Pilferer

Whenever this creature becomes untapped, you may pay {2}. If you do, draw a card.
Whenever an opponent casts a spell from anywhere other than their hand, draw a card.
Discard a card: This creature can't be blocked this turn.

Pollywog Prodigy

Evolve (Whenever a creature you control enters, if that creature has greater power or toughness than this creature, put a +1/+1 counter on this creature.)
Whenever an opponent casts a noncreature spell with mana value less than this creature's power, draw a card.

Powerbalance

Whenever an opponent casts a spell, you may reveal the top card of your library. If you do, you may cast that card without paying its mana cost if the two spells have the same mana value.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on this creature and you gain 1 life.

Smuggler's Share

At the beginning of each end step, draw a card for each opponent who drew two or more cards this turn, then create a Treasure token for each opponent who had two or more lands enter the battlefield under their control this turn.

Cindervines

Whenever an opponent casts a noncreature spell, this enchantment deals 1 damage to that player.
{1}, Sacrifice this enchantment: Destroy target artifact or enchantment. This enchantment deals 2 damage to that permanent's controller.

The Cabbage Merchant

Whenever an opponent casts a noncreature spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
Whenever a creature deals combat damage to you, sacrifice a Food token.
Tap two untapped Foods you control: Add one mana of any color.

Heartwood Storyteller

Whenever a player casts a noncreature spell, each of that player's opponents may draw a card.

Voice of Resurgence

Whenever an opponent casts a spell during your turn and when this creature dies, create a green and white Elemental creature token with "This token's power and toughness are each equal to the number of creatures you control."

March of the World Ooze

Creatures you control have base power and toughness 6/6 and are Oozes in addition to their other types.
Whenever an opponent casts a spell, if it's not their turn, you create a 3/3 green Elephant creature token.

Nezahal, Primal Tide

This spell can't be countered.
You have no maximum hand size.
Whenever an opponent casts a noncreature spell, draw a card.
Discard three cards: Exile Nezahal. Return it to the battlefield tapped under its owner's control at the beginning of the next end step.

Firemane Commando

Flying
Whenever you attack with two or more creatures, draw a card.
Whenever another player attacks with two or more creatures, they draw a card if none of those creatures attacked you.

Aerial Extortionist

Flying
Whenever this creature enters or deals combat damage to a player, exile up to one target nonland permanent. For as long as that card remains exiled, its owner may cast it.
Whenever another player casts a spell from anywhere other than their hand, draw a card.