Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Damnation

Destroy all creatures. They can't be regenerated.

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Villainous Wrath

Target opponent loses life equal to the number of creatures they control. Then destroy all creatures.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Sandman's Quicksand

Mayhem {3}{B} (You may cast this card from your graveyard for {3}{B} if you discarded it this turn. Timing rules still apply.)
All creatures get -2/-2 until end of turn. If this spell's mayhem cost was paid, creatures your opponents control get -2/-2 until end of turn instead.

Essence Pulse

You gain 2 life. Each creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Flaying Tendrils

Devoid (This card has no color.)
All creatures get -2/-2 until end of turn. If a creature would die this turn, exile it instead.

Necromantic Selection

Destroy all creatures, then return a creature card put into a graveyard this way to the battlefield under your control. It's a black Zombie in addition to its other colors and types. Exile Necromantic Selection.

Ichor Explosion

As an additional cost to cast this spell, sacrifice a creature.
All creatures get -X/-X until end of turn, where X is the sacrificed creature's power.

Tip the Scales

Sacrifice a creature. When you do, all creatures get -X/-X until end of turn, where X is the sacrificed creature's toughness.

Yahenni's Expertise

All creatures get -3/-3 until end of turn.
You may cast a spell with mana value 3 or less from your hand without paying its mana cost.

Blood Money

Destroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.

Malicious Eclipse

All creatures get -2/-2 until end of turn. If a creature an opponent controls would die this turn, exile it instead.

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

Malicious Malfunction

All creatures get -2/-2 until end of turn. If a creature would die this turn, exile it instead.

Cloudkill

All creatures get -X/-X until end of turn, where X is the greatest mana value of a commander you own on the battlefield or in the command zone.

Blight Grenade

Destroy target creature.
All creatures get -3/-3 until end of turn.

Nightmare Unmaking

Choose one —
• Exile each creature with power greater than the number of cards in your hand.
• Exile each creature with power less than the number of cards in your hand.

Final Act

Choose one or more —
• Destroy all creatures.
• Destroy all planeswalkers.
• Destroy all battles.
• Exile all graveyards.
• Each opponent loses all counters.

Consume the Meek

Destroy each creature with mana value 3 or less. They can't be regenerated.

Crippling Fear

Choose a creature type. Creatures that aren't of the chosen type get -3/-3 until end of turn.

Cry of the Carnarium

All creatures get -2/-2 until end of turn. Exile all creature cards in all graveyards that were put there from the battlefield this turn. If a creature would die this turn, exile it instead.

Night Incarnate

Deathtouch
When this creature leaves the battlefield, all creatures get -3/-3 until end of turn.
Evoke {3}{B} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Heartless Conscription

Exile all creatures. For each card exiled this way, you may play that card for as long as it remains exiled, and mana of any type can be spent to cast that spell. Exile Heartless Conscription.

Stench of Decay

Nonartifact creatures get -1/-1 until end of turn.

Their Name Is Death

Life's Finale

Destroy all creatures, then search target opponent's library for up to three creature cards and put them into their graveyard. Then that player shuffles.

Mandate of Abaddon

Choose target creature you control. Destroy all creatures with power less than that creature's power.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Extinguish All Hope

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle this card, all creatures get -2/-2 until end of turn.

Terisiare's Devastation

You lose X life and create X tapped Powerstone tokens. Then all creatures get -1/-1 until end of turn for each artifact you control. (The tokens are artifacts with "{T}: Add {C}. This mana can't be spent to cast a nonartifact spell.")

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Deadly Cover-Up

As an additional cost to cast this spell, you may collect evidence 6.
Destroy all creatures. If evidence was collected, exile a card from an opponent's graveyard. Then search its owner's graveyard, hand, and library for any number of cards with that name and exile them. That player shuffles, then draws a card for each card exiled from their hand this way.

Pestilent Haze

Choose one —
• All creatures get -2/-2 until end of turn.
• Remove two loyalty counters from each planeswalker.