Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Dire Fleet Ravager

Menace, deathtouch
When this creature enters, each player loses a third of their life, rounded up.

Kinzu of the Bleak Coven

Flying
Whenever another nontoken creature you control dies, you may pay 2 life and exile it. If you do, create a token that's a copy of that creature, except it's 1/1 and has toxic 1. (Players dealt combat damage by it also get a poison counter.)

Valgavoth, Terror Eater

Flying, lifelink
Ward—Sacrifice three nonland permanents.
If a card you didn't control would be put into an opponent's graveyard from anywhere, exile it instead.
During your turn, you may play cards exiled with Valgavoth. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.

Mask of Griselbrand

Equipped creature has flying and lifelink.
Whenever equipped creature dies, you may pay X life, where X is its power. If you do, draw X cards.
Equip {3}

Fiendish Panda

Whenever you gain life, put a +1/+1 counter on this creature.
When this creature dies, return another target non-Bear creature card with mana value less than or equal to this creature's power from your graveyard to the battlefield.

Sinkhole Surveyor

Flying
Whenever this creature attacks, you lose 1 life and this creature endures 1. (Put a +1/+1 counter on it or create a 1/1 white Spirit creature token.)

Ambition's Cost

You draw three cards and you lose 3 life.

Treasure Dredger

{1}, {T}, Pay 1 life: Create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Kaya, Geist Hunter

+1: Creatures you control gain deathtouch until end of turn. Put a +1/+1 counter on up to one target creature token you control.
−2: Until end of turn, if one or more tokens would be created under your control, twice that many of those tokens are created instead.
−6: Exile all cards from all graveyards, then create a 1/1 white Spirit creature token with flying for each card exiled this way.

The Spot, Living Portal

When The Spot enters, exile up to one target nonland permanent and up to one target nonland permanent card from a graveyard.
When The Spot dies, put him on the bottom of his owner's library. If you do, return the exiled cards to their owners' hands.

Liesa, Forgotten Archangel

Flying, lifelink
Whenever another nontoken creature you control dies, return that card to its owner's hand at the beginning of the next end step.
If a creature an opponent controls would die, exile it instead.

Azula, On the Hunt

Firebending 2 (Whenever this creature attacks, add {R}{R}. This mana lasts until end of combat.)
Whenever Azula attacks, you lose 1 life and create a Clue token. (It's an artifact with "{2}, Sacrifice this token: Draw a card.")

Street Wraith

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
Cycling—Pay 2 life. (Pay 2 life, Discard this card: Draw a card.)

Call of the Ring

At the beginning of your upkeep, the Ring tempts you.
Whenever you choose a creature as your Ring-bearer, you may pay 2 life. If you do, draw a card.

Cruel Truths

Surveil 2, then draw two cards. You lose 2 life. (To surveil 2, look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Kaya, Orzhov Usurper

+1: Exile up to two target cards from a single graveyard. You gain 2 life if at least one creature card was exiled this way.
−1: Exile target nonland permanent with mana value 1 or less.
−5: Kaya deals damage to target player equal to the number of cards that player owns in exile and you gain that much life.

Sorin, Imperious Bloodlord

+1: Target creature you control gains deathtouch and lifelink until end of turn. If it's a Vampire, put a +1/+1 counter on it.
+1: You may sacrifice a Vampire. When you do, Sorin deals 3 damage to any target and you gain 3 life.
−3: You may put a Vampire creature card from your hand onto the battlefield.

Final Payment

As an additional cost to cast this spell, pay 5 life or sacrifice a creature or enchantment.
Destroy target creature.

Basilica Guards

Defender
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Kaya, Intangible Slayer

Hexproof
+2: Each opponent loses 3 life and you gain 3 life.
0: You draw two cards. Then each opponent may scry 1.
−3: Exile target creature or enchantment. If it wasn't an Aura, create a token that's a copy of it, except it's a 1/1 white Spirit creature with flying in addition to its other types.

Grim Servant

Menace
When this creature enters, search your library for a card with mana value less than or equal to your devotion to black, reveal it, put it into your hand, then shuffle. You lose 3 life. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Indulging Patrician

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
At the beginning of your end step, if you gained 3 or more life this turn, each opponent loses 3 life.

Nyla, Shirshu Sleuth

When Nyla enters, exile up to one target creature card from your graveyard. If you do, you lose X life and create X Clue tokens, where X is that card's mana value. (A Clue token is an artifact with "{2}, Sacrifice this token: Draw a card.")
At the beginning of your end step, if you control no Clues, return target card exiled with Nyla to its owner's hand.

Treasury Thrull

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever this creature attacks, you may return target artifact, creature, or enchantment card from your graveyard to your hand.

Nocturnal Hunger

Gift a Food (You may promise an opponent a gift as you cast this spell. If you do, they create a Food token before its other effects. It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
Destroy target creature. If the gift wasn't promised, you lose 2 life.

Orzhov Signet

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap this artifact.

Metalspinner's Puzzleknot

When this artifact enters, you draw a card and you lose 1 life.
{2}{B}, Sacrifice this artifact: You draw a card and you lose 1 life.

Carmen, Cruel Skymarcher

Flying
Whenever a player sacrifices a permanent, put a +1/+1 counter on Carmen and you gain 1 life.
Whenever Carmen attacks, return up to one target permanent card with mana value less than or equal to Carmen's power from your graveyard to the battlefield.

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Mister Negative

Vigilance, lifelink
Darkforce Inversion — When Mister Negative enters, you may exchange life totals with target opponent. If you lost life this way, draw that many cards.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Midnight Reaper

Whenever a nontoken creature you control dies, this creature deals 1 damage to you and you draw a card.

Essence Channeler

As long as you've lost life this turn, this creature has flying and vigilance.
Whenever you gain life, put a +1/+1 counter on this creature.
When this creature dies, put its counters on target creature you control.

Haakon, Stromgald Scourge

You may cast this card from your graveyard, but not from anywhere else.
As long as Haakon is on the battlefield, you may cast Knight spells from your graveyard.
When Haakon dies, you lose 2 life.

Ocelot Pride

First strike, lifelink
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your end step, if you gained life this turn, create a 1/1 white Cat creature token. Then if you have the city's blessing, for each token you control that entered this turn, create a token that's a copy of it.

Infernal Idol

{T}: Add {B}.
{1}{B}{B}, {T}, Sacrifice this artifact: You draw two cards and you lose 2 life.

Obsessive Pursuit

When this enchantment enters and at the beginning of your upkeep, you lose 1 life and create a Clue token. (It's an artifact with "{2}, Sacrifice this token: Draw a card.")
Whenever you attack, put X +1/+1 counters on target attacking creature, where X is the number of permanents you've sacrificed this turn. If X is three or greater, that creature gains lifelink until end of turn.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Timeline Culler

Haste
You may cast this card from your graveyard using its warp ability.
Warp—{B}, Pay 2 life. (You may cast this card from your hand or graveyard for its warp cost. If you do, exile this creature at the beginning of the next end step, then you may cast it from exile on a later turn.)

Shay Cormac

{1}: Permanents your opponents control lose hexproof, indestructible, protection, shroud, and ward until end of turn.
Whenever a creature an opponent controls becomes the target of a spell or ability you control, put a bounty counter on that creature.
Whenever a creature with a bounty counter on it dies, put two +1/+1 counters on Shay Cormac.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Withercrown

Enchant creature
Enchanted creature has base power 0 and has "At the beginning of your upkeep, you lose 1 life unless you sacrifice this creature."

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on this creature.
Whenever you lose life during your turn, put a +1/+1 counter on this creature.

Sheoldred's Restoration

Kicker {2}{W} (You may pay an additional {2}{W} as you cast this spell.)
Return target creature card from your graveyard to the battlefield. If this spell was kicked, you gain life equal to that card's mana value. Otherwise, you lose that much life.
Exile Sheoldred's Restoration.

Razaketh, the Foulblooded

Flying, trample
Pay 2 life, Sacrifice another creature: Search your library for a card, put that card into your hand, then shuffle.

The Spot's Portal

Put target creature on the bottom of its owner's library. You lose 2 life unless you control a Villain.

Lion Vulture

Flying (This creature can't be blocked except by creatures with flying or reach.)
At the beginning of your end step, if an opponent lost life this turn, put a +1/+1 counter on this creature and draw a card. (Damage causes loss of life.)

Ardbert, Warrior of Darkness

Whenever you cast a white spell, put a +1/+1 counter on each legendary creature you control. They gain vigilance until end of turn.
Whenever you cast a black spell, put a +1/+1 counter on each legendary creature you control. They gain menace until end of turn.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Ayli, Eternal Pilgrim

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
{1}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness.
{1}{W}{B}, Sacrifice another creature: Exile target nonland permanent. Activate only if you have at least 10 life more than your starting life total.