Exterminatus

Nonland permanents your opponents control lose indestructible until end of turn.
Destroy all nonland permanents.

Worldpurge

Return all permanents to their owners' hands. Each player chooses up to seven cards in their hand, then shuffles the rest into their library. Each player loses all unspent mana.

River's Rebuke

Return all nonland permanents target player controls to their owner's hand.

Warp World

Each player shuffles all permanents they own into their library, then reveals that many cards from the top of their library. Each player puts all artifact, creature, and land cards revealed this way onto the battlefield, then does the same for enchantment cards, then puts all cards revealed this way that weren't put onto the battlefield on the bottom of their library.

Terminus

Put all creatures on the bottom of their owners' libraries.
Miracle {W} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

All Is Dust

Each player sacrifices all permanents they control that are one or more colors.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Living Death

Each player exiles all creature cards from their graveyard, then sacrifices all creatures they control, then puts all cards they exiled this way onto the battlefield.

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Crush of Tentacles

Surge {3}{U}{U} (You may cast this spell for its surge cost if you or a teammate has cast another spell this turn.)
Return all nonland permanents to their owners' hands. If this spell's surge cost was paid, create an 8/8 blue Octopus creature token.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Vacuumelt

Replicate {2}{U} (When you cast this spell, copy it for each time you paid its replicate cost. You may choose new targets for the copies.)
Return target creature to its owner's hand.

Damnation

Destroy all creatures. They can't be regenerated.

Devastation Tide

Return all nonland permanents to their owners' hands.
Miracle {1}{U} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Duneblast

Choose up to one creature. Destroy the rest.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Last One Standing

Choose a creature at random, then destroy the rest.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Supreme Verdict

This spell can't be countered.
Destroy all creatures.

Divine Reckoning

Each player chooses a creature they control. Destroy the rest.
Flashback {5}{W}{W} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Black Sun's Zenith

Put X -1/-1 counters on each creature. Shuffle Black Sun's Zenith into its owner's library.

Gaze of Granite

Destroy each nonland permanent with mana value X or less.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Wrath of God

Day of Judgment

Planar Cleansing

Upheaval

Return all permanents to their owners' hands.

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Time Wipe

Return a creature you control to its owner's hand, then destroy all creatures.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Forced March

Destroy all creatures with mana value X or less.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Hallowed Burial

Put all creatures on the bottom of their owners' libraries.

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Subterranean Tremors

Subterranean Tremors deals X damage to each creature without flying. If X is 4 or more, destroy all artifacts. If X is 8 or more, create an 8/8 red Lizard creature token.

Savage Twister

Savage Twister deals X damage to each creature.

Overwhelming Forces

Destroy all creatures target opponent controls. Draw a card for each creature destroyed this way.

Curse of the Swine

Exile X target creatures. For each creature exiled this way, its controller creates a 2/2 green Boar creature token.