Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Pitiless Horde

At the beginning of your upkeep, you lose 2 life.
Dash {2}{B}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Vampire Lacerator

At the beginning of your upkeep, you lose 1 life unless an opponent has 10 or less life.

Necrogen Scudder

Flying
When Necrogen Scudder enters, you lose 3 life.

Liliana's Contract

When Liliana's Contract enters, you draw four cards and you lose 4 life.
At the beginning of your upkeep, if you control four or more Demons with different names, you win the game.

Infernal Grasp

Destroy target creature. You lose 2 life.

Carnival of Souls

Whenever a creature enters, you lose 1 life and add {B}.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Junji, the Midnight Sky

Flying, menace
When Junji, the Midnight Sky dies, choose one —
• Each opponent discards two cards and loses 2 life.
• Put target non-Dragon creature card from a graveyard onto the battlefield under your control. You lose 2 life.

Dross Harvester

Protection from white
At the beginning of your end step, you lose 4 life.
Whenever a creature dies, you gain 2 life.

Shauku, Endbringer

Flying
Shauku, Endbringer can't attack if there's another creature on the battlefield.
At the beginning of your upkeep, you lose 3 life.
{T}: Exile target creature and put a +1/+1 counter on Shauku.

Ruin Raider

Raid — At the beginning of your end step, if you attacked this turn, reveal the top card of your library and put that card into your hand. You lose life equal to the card's mana value.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Pain Seer

Inspired — Whenever Pain Seer becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When Murderous Rider dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Metalspinner's Puzzleknot

When Metalspinner's Puzzleknot enters, you draw a card and you lose 1 life.
{2}{B}, Sacrifice Metalspinner's Puzzleknot: You draw a card and you lose 1 life.

Grinning Demon

At the beginning of your upkeep, you lose 2 life.
Morph {2}{B}{B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Wretched Anurid

Whenever another creature enters, you lose 1 life.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Dreadhorde Invasion

At the beginning of your upkeep, you lose 1 life and amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)
Whenever a Zombie token you control with power 6 or greater attacks, it gains lifelink until end of turn.

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Wicked Pact

Baleful Force

At the beginning of each upkeep, you draw a card and you lose 1 life.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Ancient Craving

You draw three cards and you lose 3 life.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Phyrexian Gargantua

When Phyrexian Gargantua enters, you draw two cards and you lose 2 life.

Herald of Torment

Bestow {3}{B}{B} (If you cast this card for its bestow cost, it's an Aura spell with enchant creature. It becomes a creature again if it's not attached to a creature.)
Flying
At the beginning of your upkeep, you lose 1 life.
Enchanted creature gets +3/+3 and has flying.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Succumb to Temptation

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Imperial Seal

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Phyrexian Delver

When Phyrexian Delver enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Hoarder's Greed

You lose 2 life and draw two cards, then clash with an opponent. If you win, repeat this process. (Each clashing player reveals the top card of their library, then puts that card on the top or bottom. A player wins if their card had a higher mana value.)

Dark Tutelage

Reaver Drone

Devoid (This card has no color.)
At the beginning of your upkeep, you lose 1 life unless you control another colorless creature.

Bitterblossom

At the beginning of your upkeep, you lose 1 life and create a 1/1 black Faerie Rogue creature token with flying.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Diviner's Wand

Equipped creature has "Whenever you draw a card, this creature gets +1/+1 and gains flying until end of turn" and "{4}: Draw a card."
Whenever a Wizard creature enters, you may attach Diviner's Wand to it.
Equip {3}

Bellowing Saddlebrute

Raid — When Bellowing Saddlebrute enters, you lose 4 life unless you attacked this turn.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Eviscerator

Protection from white
When Eviscerator enters, you lose 5 life.

Ebon Drake

Flying
Whenever a player casts a spell, you lose 1 life.

Vampiric Spirit

Flying
When Vampiric Spirit enters, you lose 4 life.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Serpent Warrior

When Serpent Warrior enters, you lose 3 life.

Dread Reaper

Flying
When Dread Reaper enters, you lose 5 life.

Ambition's Cost

Foul Imp

Flying
When Foul Imp enters, you lose 2 life.

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice Gonti's Machinations: Each opponent loses 3 life. You gain life equal to the life lost this way.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Vampiric Tutor

Boon of Erebos

Target creature gets +2/+0 until end of turn. Regenerate it. You lose 2 life.

Cruel Tutor

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Treacherous Blessing

When Treacherous Blessing enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When Treacherous Blessing becomes the target of a spell or ability, sacrifice it.

Clattering Augur

Clattering Augur can't block.
When Clattering Augur enters, you draw a card and you lose 1 life.
{2}{B}{B}: Return Clattering Augur from your graveyard to your hand.

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth, Spider Queen.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Priest of the Blood Rite

When Priest of the Blood Rite enters, create a 5/5 black Demon creature token with flying.
At the beginning of your upkeep, you lose 2 life.