Screamer-Killer

Trample
Bio-Plasmic Scream — Whenever you cast a creature spell with mana value 5 or greater, Screamer-Killer deals 5 damage to any target.

Lightning Axe

As an additional cost to cast this spell, discard a card or pay {5}.
Lightning Axe deals 5 damage to target creature.

Where Ancients Tread

Whenever a creature you control with power 5 or greater enters, you may have Where Ancients Tread deal 5 damage to any target.

Mine Collapse

If it's your turn, you may sacrifice a Mountain rather than pay this spell's mana cost.
Mine Collapse deals 5 damage to target creature or planeswalker.

Fire Diamond

Fire Diamond enters tapped.
{T}: Add {R}.

Engulfing Eruption

Engulfing Eruption deals 5 damage to target creature.

Rebel Salvo

Affinity for Equipment (This spell costs {1} less to cast for each Equipment you control.)
Rebel Salvo deals 5 damage to target creature or planeswalker. That permanent loses indestructible until end of turn.

Five-Alarm Fire

Whenever a creature you control deals combat damage, put a blaze counter on Five-Alarm Fire.
Remove five blaze counters from Five-Alarm Fire: It deals 5 damage to any target.

Tears of Valakut

This spell can't be countered.
Tears of Valakut deals 5 damage to target creature with flying.

Reduce to Ashes

Reduce to Ashes deals 5 damage to target creature. If that creature would die this turn, exile it instead.

Final Flare

As an additional cost to cast this spell, sacrifice a creature or enchantment.
Final Flare deals 5 damage to target creature.

Fated Conflagration

Fated Conflagration deals 5 damage to target creature or planeswalker. If it's your turn, scry 2.

Searing Barrage

Searing Barrage deals 5 damage to target creature.
Adamant — If at least three red mana was spent to cast this spell, Searing Barrage deals 3 damage to that creature's controller.

Soul Sear

Soul Sear deals 5 damage to target creature or planeswalker. That permanent loses indestructible until end of turn.

Imodane, the Pyrohammer

Whenever an instant or sorcery spell you control that targets only a single creature deals damage to that creature, Imodane deals that much damage to each opponent.

Fiery Intervention

Choose one —
• Fiery Intervention deals 5 damage to target creature.
• Destroy target artifact.

This spell can't be countered.
Fry deals 5 damage to target creature or planeswalker that's white or blue.

Puncturing Blow

Puncturing Blow deals 5 damage to target creature. If that creature would die this turn, exile it instead.

Flamewave Invoker

{7}{R}: Flamewave Invoker deals 5 damage to target player or planeswalker.

Ready to Rumble

Choose one —
• Ready to Rumble deals 5 damage to target creature or planeswalker.
• Destroy target artifact.

Turn to Slag

Turn to Slag deals 5 damage to target creature. Destroy all Equipment attached to that creature.

Brimstone Volley

Brimstone Volley deals 3 damage to any target.
Morbid — Brimstone Volley deals 5 damage instead if a creature died this turn.

Rending Flame

Rending Flame deals 5 damage to target creature or planeswalker. If that permanent is a Spirit, Rending Flame also deals 2 damage to that permanent's controller.

Hour of Devastation

All creatures lose indestructible until end of turn. Hour of Devastation deals 5 damage to each creature and each non-Bolas planeswalker.

Thunderous Wrath

Thunderous Wrath deals 5 damage to any target.
Miracle {R} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Sarkhan's Rage

Sarkhan's Rage deals 5 damage to any target. If you control no Dragons, Sarkhan's Rage deals 2 damage to you.

Nahiri's Warcrafting

Nahiri's Warcrafting deals 5 damage to target creature, planeswalker, or battle. Look at the top X cards of your library, where X is the excess damage dealt this way. You may exile one of those cards. Put the rest on the bottom of your library in a random order. You may play the exiled card this turn.

Blastfire Bolt

Blastfire Bolt deals 5 damage to target creature. Destroy all Equipment attached to that creature.

Browbeat

Any player may have Browbeat deal 5 damage to them. If no one does, target player draws three cards.

Explosive Impact

Explosive Impact deals 5 damage to any target.

Pharagax Giant

Tribute 2 (As this creature enters, an opponent of your choice may put two +1/+1 counters on it.)
When Pharagax Giant enters, if tribute wasn't paid, Pharagax Giant deals 5 damage to each opponent.

Reaver Titan

Void Shields — Protection from mana value 3 or less
Gatling Blaster — Whenever Reaver Titan attacks, it deals 5 damage to each opponent.
Crew 4 (Tap any number of creatures you control with total power 4 or more: This Vehicle becomes an artifact creature until end of turn.)

Fiery Fall

Fiery Fall deals 5 damage to target creature.
Basic landcycling {1}{R} ({1}{R}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Form of the Dragon

At the beginning of your upkeep, Form of the Dragon deals 5 damage to any target.
At the beginning of each end step, your life total becomes 5.
Creatures without flying can't attack you.

Font of Ire

{3}{R}, Sacrifice Font of Ire: It deals 5 damage to target player or planeswalker.

Jaya's Firenado

Jaya's Firenado deals 5 damage to target creature or planeswalker. Scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Dragon Cultist

Commander creatures you own have "At the beginning of your end step, if a source you controlled dealt 5 or more damage this turn, create a 4/4 red Dragon creature token with flying."

Pigment Storm

Pigment Storm deals 5 damage to target creature. Excess damage is dealt to that creature's controller instead.

Fight with Fire

Kicker {5}{R} (You may pay an additional {5}{R} as you cast this spell.)
Fight with Fire deals 5 damage to target creature. If this spell was kicked, it deals 10 damage divided as you choose among any number of targets instead. (Those targets can include players and planeswalkers.)

Needletooth Raptor

Enrage — Whenever Needletooth Raptor is dealt damage, it deals 5 damage to target creature an opponent controls.

Bogardan Hellkite

Flash
Flying
When Bogardan Hellkite enters, it deals 5 damage divided as you choose among any number of targets.

Fiery Conclusion

As an additional cost to cast this spell, sacrifice a creature.
Fiery Conclusion deals 5 damage to target creature.

Lava Axe

Lava Axe deals 5 damage to target player or planeswalker.

Burn the Accursed

Burn the Accursed deals 5 damage to target creature and 2 damage to that creature's controller. If that creature would die this turn, exile it instead.

Demanding Dragon

Flying
When Demanding Dragon enters, it deals 5 damage to target opponent unless that player sacrifices a creature of their choice.

Retributive Wand

{3}, {T}: Retributive Wand deals 1 damage to any target.
When Retributive Wand is put into a graveyard from the battlefield, it deals 5 damage to any target.

Explosive Welcome

Explosive Welcome deals 5 damage to any target and 3 damage to any other target. Add {R}{R}{R}.

Shrapnel Blast

As an additional cost to cast this spell, sacrifice an artifact.
Shrapnel Blast deals 5 damage to any target.

Flame Blitz

At the beginning of your end step, Flame Blitz deals 5 damage to each planeswalker.
Cycling {2} ({2}, Discard this card: Draw a card.)

Ryusei, the Falling Star

Flying
When Ryusei, the Falling Star dies, it deals 5 damage to each creature without flying.

Livaan, Cultist of Tiamat

Whenever you cast a noncreature spell, target creature gets +X/+0 until end of turn, where X is that spell's mana value.
Choose a Background (You can have a Background as a second commander.)

Roast

Roast deals 5 damage to target creature without flying.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Magmatic Galleon

When Magmatic Galleon enters, it deals 5 damage to target creature an opponent controls.
Whenever one or more creatures your opponents control are dealt excess noncombat damage, create a Treasure token.
Crew 2

Explosion of Riches

Draw a card, then each other player may draw a card. Whenever a card is drawn this way, Explosion of Riches deals 5 damage to target opponent chosen at random from among your opponents.

Beacon of Destruction

Beacon of Destruction deals 5 damage to any target. Shuffle Beacon of Destruction into its owner's library.

Devour in Flames

As an additional cost to cast this spell, return a land you control to its owner's hand.
Devour in Flames deals 5 damage to target creature or planeswalker.

Witchstalker Frenzy

This spell costs {1} less to cast for each creature that attacked this turn.
Witchstalker Frenzy deals 5 damage to target creature.

Farideh's Fireball

Farideh's Fireball deals 5 damage to target creature or planeswalker. Roll a d20.
1—9 | Farideh's Fireball deals 2 damage to each player.
10—20 | Farideh's Fireball deals 2 damage to each opponent.

Mountain

Sarkhan's Catharsis

Sarkhan's Catharsis deals 5 damage to target player or planeswalker.

Chandra's Defeat

Chandra's Defeat deals 5 damage to target red creature or red planeswalker. If that permanent is a Chandra planeswalker, you may discard a card. If you do, draw a card.

Burn Down the House

Choose one —
• Burn Down the House deals 5 damage to each creature and each planeswalker.
• Create three 1/1 red Devil creature tokens with "When this creature dies, it deals 1 damage to any target." They gain haste until end of turn.

Scorching Shot

Scorching Shot deals 5 damage to target creature.

Sol Ring

Chandra, Torch of Defiance

+1: Exile the top card of your library. You may cast that card. If you don't, Chandra, Torch of Defiance deals 2 damage to each opponent.
+1: Add {R}{R}.
−3: Chandra, Torch of Defiance deals 4 damage to target creature.
−7: You get an emblem with "Whenever you cast a spell, this emblem deals 5 damage to any target."

Magmatic Sinkhole

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Magmatic Sinkhole deals 5 damage to target creature or planeswalker.

Delayed Blast Fireball

Delayed Blast Fireball deals 2 damage to each opponent and each creature they control. If this spell was cast from exile, it deals 5 damage to each opponent and each creature they control instead.
Foretell {4}{R}{R} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Magma Rift

As an additional cost to cast this spell, sacrifice a land.
Magma Rift deals 5 damage to target creature.