Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Life Insurance

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever a nontoken creature dies, you lose 1 life and create a Treasure token.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Razaketh, the Foulblooded

Flying, trample
Pay 2 life, Sacrifice another creature: Search your library for a card, put that card into your hand, then shuffle.

Mirror Universe

{T}, Sacrifice Mirror Universe: Exchange life totals with target opponent. Activate only during your upkeep.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Street Wraith

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
Cycling—Pay 2 life. (Pay 2 life, Discard this card: Draw a card.)

Banshee

{X}, {T}: Banshee deals half X damage, rounded down, to any target, and half X damage, rounded up, to you.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Center Soul

Target creature you control gains protection from the color of your choice until end of turn.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Asmodeus the Archfiend

Binding Contract — If you would draw a card, exile the top card of your library face down instead.
{B}{B}{B}: Draw seven cards.
{B}: Return all cards exiled with Asmodeus the Archfiend to their owner's hand and you lose that much life.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Underworld Coinsmith

Constellation — Whenever Underworld Coinsmith or another enchantment you control enters, you gain 1 life.
{W}{B}, Pay 1 life: Each opponent loses 1 life.

Tymna the Weaver

Lifelink
At the beginning of each of your postcombat main phases, you may pay X life, where X is the number of opponents that were dealt combat damage this turn. If you do, draw X cards.
Partner (You can have two commanders if both have partner.)

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Ebonblade Reaper

Whenever Ebonblade Reaper attacks, you lose half your life, rounded up.
Whenever Ebonblade Reaper deals combat damage to a player, that player loses half their life, rounded up.
Morph {3}{B}{B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on Bloodtracker.
When Bloodtracker leaves the battlefield, draw a card for each +1/+1 counter on it.

Stirge

Flying
Stirge can't block.
Blood Drain — {1}{B}, Pay 1 life, Sacrifice Stirge: Draw a card.

Mystic Forge

You may look at the top card of your library any time.
You may cast artifact spells and colorless spells from the top of your library.
{T}, Pay 1 life: Exile the top card of your library.

Grimclaw Bats

Flying
{B}, Pay 1 life: Grimclaw Bats gets +1/+1 until end of turn.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Righteous Aura

{W}, Pay 2 life: The next time a source of your choice would deal damage to you this turn, prevent that damage.

Bloodsoaked Altar

{T}, Pay 2 life, Discard a card, Sacrifice a creature: Create a 5/5 black Demon creature token with flying. Activate only as a sorcery.

Mortarion, Daemon Primarch

Flying
Primarch of the Death Guard — At the beginning of your end step, you may pay {X}. If you do, create X 2/2 black Astartes Warrior creature tokens with menace. X can't be greater than the amount of life you lost this turn.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Sol Ring

Forsworn Paladin

Menace
{1}{B}, {T}, Pay 1 life: Create a Treasure token.
{2}{B}: Target creature gets +2/+0 until end of turn. If mana from a Treasure was spent to activate this ability, that creature also gains deathtouch until end of turn.

Inherited Fiend

Flying
{2}{B}: Exile target creature card from a graveyard. Put a +1/+1 counter on Inherited Fiend.

Heirloom Mirror

{1}, {T}, Pay 1 life, Discard a card: Draw a card, mill a card, then put a ritual counter on Heirloom Mirror. Then if it has three or more ritual counters on it, remove them and transform it. Activate only as a sorcery.

Heirloom Mirror // Inherited Fiend

Verrak, Warped Sengir

Flying, deathtouch, lifelink
Whenever you activate an ability that isn't a mana ability, if life was paid to activate it, you may pay that much life again. If you do, copy that ability. You may choose new targets for the copy.

Omen Machine

Players can't draw cards.
At the beginning of each player's draw step, that player exiles the top card of their library. If it's a land card, the player puts it onto the battlefield. Otherwise, the player casts it without paying its mana cost if able.

Crypt Rats

{X}: Crypt Rats deals X damage to each creature and each player. Spend only black mana on X.

Sinister Concoction

{B}, Pay 1 life, Mill a card, Discard a card, Sacrifice Sinister Concoction: Destroy target creature.

Phyrexian Reclamation

{1}{B}, Pay 2 life: Return target creature card from your graveyard to your hand.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Chainer, Dementia Master

All Nightmares get +1/+1.
{B}{B}{B}, Pay 3 life: Put target creature card from a graveyard onto the battlefield under your control. That creature is black and is a Nightmare in addition to its other creature types.
When Chainer, Dementia Master leaves the battlefield, exile all Nightmares.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Night's Whisper

Oracle's Vault

{2}, {T}: Exile the top card of your library. Until end of turn, you may play that card. Put a brick counter on Oracle's Vault.
{T}: Exile the top card of your library. Until end of turn, you may play that card without paying its mana cost. Activate only if there are three or more brick counters on Oracle's Vault.

Sign in Blood

Target player draws two cards and loses 2 life.

Priest of Fell Rites

{T}, Pay 3 life, Sacrifice Priest of Fell Rites: Return target creature card from your graveyard to the battlefield. Activate only as a sorcery.
Unearth {3}{W}{B} ({3}{W}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Lorcan, Warlock Collector

Flying
Whenever a creature card is put into an opponent's graveyard from anywhere, you may pay life equal to its mana value. If you do, put it onto the battlefield under your control. It's a Warlock in addition to its other types.
If a Warlock you control would die, exile it instead.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Carrion Howler

Pay 1 life: Carrion Howler gets +2/-1 until end of turn.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Glass-Cast Heart

Whenever one or more Vampires you control attack, create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")
{B}, {T}, Pay 1 life: Create a 1/1 white and black Vampire creature token with lifelink.
{B}{B}, {T}, Sacrifice Glass-Cast Heart and thirteen Blood tokens: Each opponent loses 13 life and you gain 13 life.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Arrogant Poet

Whenever Arrogant Poet attacks, you may pay 2 life. If you do, it gains flying until end of turn.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Strands of Night

{B}{B}, Pay 2 life, Sacrifice a Swamp: Return target creature card from your graveyard to the battlefield.

Plains

Orzhov Signet

Greed

Swamp

Vona, Butcher of Magan

Vigilance, lifelink
{T}, Pay 7 life: Destroy target nonland permanent. Activate only during your turn.

Cruel Sadist

{B}, {T}, Pay 1 life: Put a +1/+1 counter on Cruel Sadist.
{2}{B}, {T}, Remove X +1/+1 counters from Cruel Sadist: It deals X damage to target creature.

Beacon of Immortality

Double target player's life total. Shuffle Beacon of Immortality into its owner's library.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.