Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Elderfang Disciple

When Elderfang Disciple enters, each opponent discards a card.

Skullslither Worm

When Skullslither Worm enters, each opponent discards a card. For each opponent who can't, put two +1/+1 counters on Skullslither Worm.

Devour Intellect

Target opponent discards a card. If mana from a Treasure was spent to cast this spell, instead that player reveals their hand, you choose a nonland card from it, then that player discards that card.

Fake Your Own Death

Until end of turn, target creature gets +2/+0 and gains "When this creature dies, return it to the battlefield tapped under its owner's control and you create a Treasure token." (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Honden of Night's Reach

At the beginning of your upkeep, target opponent discards a card for each Shrine you control.

Reckoner Shakedown

Target opponent reveals their hand. You may choose a nonland card from it. If you do, that player discards that card. If you don't, put two +1/+1 counters on a creature or Vehicle you control.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

Hymn to Tourach

Target player discards two cards at random.

Gix's Caress

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.
Create a tapped Powerstone token. (It's an artifact with "{T}: Add {C}. This mana can't be spent to cast a nonartifact spell.")

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Armor of Shadows

Until end of turn, target creature gets +1/+0 and gains indestructible. (Damage and effects that say "destroy" don't destroy it.)

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Lay Bare the Heart

Target opponent reveals their hand. You choose a nonlegendary, nonland card from it. That player discards that card.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Diplomacy of the Wastes

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card. If you control a Warrior, that player loses 2 life.

Unnerve

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Darksteel Plate

Indestructible
Equipped creature has indestructible.
Equip {2}

Burglar Rat

When this creature enters, each opponent discards a card.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Elvish Doomsayer

When Elvish Doomsayer dies, each opponent discards a card.

Toll of the Invasion

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.
Amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)

Pilfer

Target opponent reveals their hand. You choose a nonland card from it. That player discards that card.

Undying Malice

Until end of turn, target creature gains "When this creature dies, return it to the battlefield tapped under its owner's control with a +1/+1 counter on it."

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Protection Racket

At the beginning of your upkeep, repeat the following process for each opponent in turn order. Reveal the top card of your library. That player may pay life equal to that card's mana value. If they do, exile that card. Otherwise, put it into your hand.

Maralen of the Mornsong

Players can't draw cards.
At the beginning of each player's draw step, that player loses 3 life, searches their library for a card, puts it into their hand, then shuffles.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Dark Inquiry

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.