Idea

Blightsteel Colossus

Trample, infect, indestructible
If Blightsteel Colossus would be put into a graveyard from anywhere, reveal Blightsteel Colossus and shuffle it into its owner's library instead.

Have

Phyrexian Swarmlord

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
At the beginning of your upkeep, create a 1/1 green Phyrexian Insect creature token with infect for each poison counter your opponents have.

Viral Drake

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{3}{U}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Nature's Claim

Destroy target artifact or enchantment. Its controller gains 4 life.

Merfolk Skydiver

Flying
When Merfolk Skydiver enters, put a +1/+1 counter on target creature you control.
{3}{G}{U}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Tainted Strike

Target creature gets +1/+0 and gains infect until end of turn. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Bring the Ending

Counter target spell unless its controller pays {2}.
Corrupted — Counter that spell instead if its controller has three or more poison counters.

Contagion Clasp

When Contagion Clasp enters, put a -1/-1 counter on target creature.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Vorinclex, Monstrous Raider

Trample, haste
If you would put one or more counters on a permanent or player, put twice that many of each of those kinds of counters on that permanent or player instead.
If an opponent would put one or more counters on a permanent or player, they put half that many of each of those kinds of counters on that permanent or player instead, rounded down.

Herald of Secret Streams

Creatures you control with +1/+1 counters on them can't be blocked.

Master Biomancer

Each other creature you control enters with a number of additional +1/+1 counters on it equal to Master Biomancer's power and as a Mutant in addition to its other types.

Steady Progress

Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)
Draw a card.

Infernal Grasp

Destroy target creature. You lose 2 life.

Venerated Rotpriest

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever a creature you control becomes the target of a spell, target opponent gets a poison counter.

Getting

Druid of Purification

When Druid of Purification enters, starting with you, each player may choose an artifact or enchantment you don't control. Destroy each permanent chosen this way.

Simic Growth Chamber

Simic Growth Chamber enters tapped.
When Simic Growth Chamber enters, return a land you control to its owner's hand.
{T}: Add {G}{U}.

Thriving Moor

Thriving Moor enters tapped. As it enters, choose a color other than black.
{T}: Add {B} or one mana of the chosen color.

Karn's Bastion

{T}: Add {C}.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Growth Spiral

Draw a card. You may put a land card from your hand onto the battlefield.

Core Prowler

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Core Prowler dies, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Spinebiter

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
You may have Spinebiter assign its combat damage as though it weren't blocked.

Reaper of Sheoldred

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever a source deals damage to Reaper of Sheoldred, that source's controller gets a poison counter.

Bloated Contaminator

Trample
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever Bloated Contaminator deals combat damage to a player, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Forest

Llanowar Wastes

{T}: Add {C}.
{T}: Add {B} or {G}. Llanowar Wastes deals 1 damage to you.

Hapatra, Vizier of Poisons

Whenever Hapatra, Vizier of Poisons deals combat damage to a player, you may put a -1/-1 counter on target creature.
Whenever you put one or more -1/-1 counters on a creature, create a 1/1 green Snake creature token with deathtouch.

Unnatural Restoration

Return target permanent card from your graveyard to your hand. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Sultai Charm

Choose one —
• Destroy target monocolored creature.
• Destroy target artifact or enchantment.
• Draw two cards, then discard a card.

Expand the Sphere

Look at the top six cards of your library. Put up to two land cards from among them onto the battlefield tapped and the rest on the bottom of your library in a random order. If you put fewer than two lands onto the battlefield this way, proliferate a number of times equal to the difference. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Inexorable Tide

Whenever you cast a spell, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Blight Mamba

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{1}{G}: Regenerate Blight Mamba.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Dimir Aqueduct

Dimir Aqueduct enters tapped.
When Dimir Aqueduct enters, return a land you control to its owner's hand.
{T}: Add {U}{B}.

Grim Affliction

Put a -1/-1 counter on target creature, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Infectious Bite

Target creature you control deals damage equal to its power to target creature you don't control. Each opponent gets a poison counter.

Golgari Signet

Tezzeret's Gambit

({U/P} can be paid with either {U} or 2 life.)
Draw two cards, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Lifecrafter's Bestiary

At the beginning of your upkeep, scry 1.
Whenever you cast a creature spell, you may pay {G}. If you do, draw a card.

Arcane Signet

Volrath, the Shapestealer

At the beginning of combat on your turn, put a -1/-1 counter on up to one target creature.
{1}: Until your next turn, Volrath, the Shapestealer becomes a copy of target creature with a counter on it, except it's 7/5 and it has this ability.

Corpse Cur

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Corpse Cur enters, you may return target creature card with infect from your graveyard to your hand.

Master Chef

Commander creatures you own have "This creature enters with an additional +1/+1 counter on it" and "Other creatures you control enter with an additional +1/+1 counter on them."

Mind's Eye

Whenever an opponent draws a card, you may pay {1}. If you do, draw a card.

Worldly Tutor

Search your library for a creature card, reveal it, then shuffle and put the card on top.

Phyrexian Hydra

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
If damage would be dealt to Phyrexian Hydra, prevent that damage. Put a -1/-1 counter on Phyrexian Hydra for each 1 damage prevented this way.

Loyal Guardian

Trample
Lieutenant — At the beginning of combat on your turn, if you control your commander, put a +1/+1 counter on each creature you control.

Contentious Plan

Assassin's Trophy

Destroy target permanent an opponent controls. Its controller may search their library for a basic land card, put it onto the battlefield, then shuffle.

Counterspell

Jiang Yanggu, Wildcrafter

Each creature you control with a +1/+1 counter on it has "{T}: Add one mana of any color."
−1: Put a +1/+1 counter on target creature.

Ezuri, Stalker of Spheres

When Ezuri, Stalker of Spheres enters, you may pay {3}. If you do, proliferate twice.
Whenever you proliferate, draw a card.

Treasure Cruise

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Draw three cards.

Biophagus

Genomic Enhancement — {T}: Add one mana of any color. If this mana is spent to cast a creature spell, that creature enters with an additional +1/+1 counter on it.

Return of the Wildspeaker

Choose one —
• Draw cards equal to the greatest power among non-Human creatures you control.
• Non-Human creatures you control get +3/+3 until end of turn.

Courage in Crisis

Put a +1/+1 counter on target creature, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Don't Have

Necropede

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Necropede dies, you may put a -1/-1 counter on target creature.

Tamiyo's Safekeeping

Target permanent you control gains hexproof and indestructible until end of turn. You gain 2 life. (A permanent with hexproof and indestructible can't be the target of spells or abilities your opponents control. Damage and effects that say "destroy" don't destroy it.)

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Generous Patron

When Generous Patron enters, support 2. (Put a +1/+1 counter on each of up to two other target creatures.)
Whenever you put one or more counters on a creature you don't control, draw a card.

Beast Whisperer

Whenever you cast a creature spell, draw a card.

Negate

Skithiryx, the Blight Dragon

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{B}: Skithiryx, the Blight Dragon gains haste until end of turn.
{B}{B}: Regenerate Skithiryx.

Rampant Growth

Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Blighted Agent

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Blighted Agent can't be blocked.

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Venser, Corpse Puppet

Lifelink, toxic 1
Whenever you proliferate, choose one —
• If you don't control a creature named The Hollow Sentinel, create The Hollow Sentinel, a legendary 3/3 colorless Phyrexian Golem artifact creature token.
• Target artifact creature you control gains flying and lifelink until end of turn.

Defiler of Vigor

Trample
As an additional cost to cast green permanent spells, you may pay 2 life. Those spells cost {G} less to cast if you paid life this way. This effect reduces only the amount of green mana you pay.
Whenever you cast a green permanent spell, put a +1/+1 counter on each creature you control.

Primal Empathy

At the beginning of your upkeep, draw a card if you control a creature with the greatest power among creatures on the battlefield. Otherwise, put a +1/+1 counter on a creature you control.

Bane of Progress

When Bane of Progress enters, destroy all artifacts and enchantments. Put a +1/+1 counter on Bane of Progress for each permanent destroyed this way.

Slip Through Space

Devoid (This card has no color.)
Target creature can't be blocked this turn.
Draw a card.

Phyrexian Crusader

First strike, protection from red and from white
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Farseek

Search your library for a Plains, Island, Swamp, or Mountain card, put it onto the battlefield tapped, then shuffle.

Mishra's Bauble

{T}, Sacrifice Mishra's Bauble: Look at the top card of target player's library. Draw a card at the beginning of the next turn's upkeep.

Whispersilk Cloak

Equipped creature can't be blocked and has shroud. (It can't be the target of spells or abilities.)
Equip {2}

Simic Signet

Tekuthal, Inquiry Dominus

Flying
If you would proliferate, proliferate twice instead.
{1}{U/P}{U/P}, Remove three counters from among other artifacts, creatures, and planeswalkers you control: Put an indestructible counter on Tekuthal, Inquiry Dominus. ({U/P} can be paid with either {U} or 2 life.)

Reject Imperfection

Counter target spell. If that spell's mana value was 3 or less, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Bilious Skulldweller

Deathtouch
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)

Plague Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{T}: Add {C}.

Sunken Hollow

({T}: Add {U} or {B}.)
Sunken Hollow enters tapped unless you control two or more basic lands.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Smell Fear

Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)
Target creature you control fights up to one target creature you don't control.

Arcane Denial

Counter target spell. Its controller may draw up to two cards at the beginning of the next turn's upkeep.
You draw a card at the beginning of the next turn's upkeep.

Overwhelming Stampede

Until end of turn, creatures you control gain trample and get +X/+X, where X is the greatest power among creatures you control.

Glistener Elf

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Roalesk, Apex Hybrid

Flying, trample
When Roalesk, Apex Hybrid enters, put two +1/+1 counters on another target creature you control.
When Roalesk dies, proliferate, then proliferate again. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Beast Within

Destroy target permanent. Its controller creates a 3/3 green Beast creature token.

Inkmoth Nexus

{T}: Add {C}.
{1}: Inkmoth Nexus becomes a 1/1 Phyrexian Blinkmoth artifact creature with flying and infect until end of turn. It's still a land. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Harmonize

Viridian Corrupter

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Viridian Corrupter enters, destroy target artifact.

Island

Drown in Ichor

Target creature gets -4/-4 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Grafted Exoskeleton

Equipped creature gets +2/+2 and has infect. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever Grafted Exoskeleton becomes unattached from a permanent, sacrifice that permanent.
Equip {2}

Cultivate

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Glistening Sphere

Glistening Sphere enters tapped.
When Glistening Sphere enters, proliferate.
{T}: Add one mana of any color.
Corrupted — {T}: Add three mana of any one color. Activate only if an opponent has three or more poison counters.

Yavimaya Coast

{T}: Add {C}.
{T}: Add {G} or {U}. Yavimaya Coast deals 1 damage to you.

Winged Temple of Orazca

(Transforms from Hadana's Climb.)
{T}: Add one mana of any color.
{1}{G}{U}, {T}: Target creature you control gains flying and gets +X/+X until end of turn, where X is its power.

Hadana's Climb

At the beginning of combat on your turn, put a +1/+1 counter on target creature you control. Then if that creature has three or more +1/+1 counters on it, transform Hadana's Climb.

Hadana's Climb // Winged Temple of Orazca

Putrefy

Destroy target artifact or creature. It can't be regenerated.

Plague Stinger

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)