Go for the Throat

Yawgmoth, Thran Physician

Protection from Humans
Pay 1 life, Sacrifice another creature: Put a -1/-1 counter on up to one target creature and draw a card.
{B}{B}, Discard a card: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Tezzeret the Seeker

+1: Untap up to two target artifacts.
−X: Search your library for an artifact card with mana value X or less, put it onto the battlefield, then shuffle.
−5: Artifacts you control become artifact creatures with base power and toughness 5/5 until end of turn.

Voidwing Hybrid

Flying
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
When you proliferate, return this card from your graveyard to your hand.

Counterspell

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap this artifact.

Throne of Geth

{T}, Sacrifice an artifact: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Black Sun's Zenith

Put X -1/-1 counters on each creature. Shuffle Black Sun's Zenith into its owner's library.

Underground River

{T}: Add {C}.
{T}: Add {U} or {B}. This land deals 1 damage to you.

Blightbelly Rat

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
When this creature dies, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Muddle the Mixture

Counter target instant or sorcery spell.
Transmute {1}{U}{U} ({1}{U}{U}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then shuffle. Transmute only as a sorcery.)

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Corrupted Resolve

Counter target spell if its controller is poisoned.

Reject Imperfection

Counter target spell. If that spell's mana value was 3 or less, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Karn's Bastion

{T}: Add {C}.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Guildpact Informant

Flying
Whenever this creature deals combat damage to a player or planeswalker, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Dross Scorpion

Whenever this creature or another artifact creature dies, you may untap target artifact.

Swamp

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

Steady Progress

Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)
Draw a card.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Whir of Invention

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Search your library for an artifact card with mana value X or less, put it onto the battlefield, then shuffle.

An Offer You Can't Refuse

Counter target noncreature spell. Its controller creates two Treasure tokens. (They're artifacts with "{T}, Sacrifice this token: Add one mana of any color.")

Gitaxian Probe

({U/P} can be paid with either {U} or 2 life.)
Look at target player's hand.
Draw a card.

River of Tears

{T}: Add {U}. If you played a land this turn, add {B} instead.

Arcane Signet

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Myr Convert

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
{T}, Pay 2 life: Add one mana of any color.

Reshape

As an additional cost to cast this spell, sacrifice an artifact.
Search your library for an artifact card with mana value X or less, put it onto the battlefield, then shuffle.

Phyresis Outbreak

Each opponent gets a poison counter. Then each creature your opponents control gets -1/-1 until end of turn for each poison counter its controller has.

Blighted Agent

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
This creature can't be blocked.

Core Prowler

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When this creature dies, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Sunken Hollow

({T}: Add {U} or {B}.)
This land enters tapped unless you control two or more basic lands.

Island

Talisman of Dominance

{T}: Add {C}.
{T}: Add {U} or {B}. This artifact deals 1 damage to you.

Scheming Aspirant

Whenever you proliferate, each opponent loses 2 life and you gain 2 life.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Tainted Isle

{T}: Add {C}.
{T}: Add {U} or {B}. Activate only if you control a Swamp.

Fabricate

Search your library for an artifact card, reveal it, put it into your hand, then shuffle.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Shipwreck Marsh

This land enters tapped unless you control two or more other lands.
{T}: Add {U} or {B}.

Toxrill, the Corrosive

At the beginning of each end step, put a slime counter on each creature you don't control.
Creatures you don't control get -1/-1 for each slime counter on them.
Whenever a creature you don't control with a slime counter on it dies, create a 1/1 black Slug creature token.
{U}{B}, Sacrifice a Slug: Draw a card.

Midnight Clock

{T}: Add {U}.
{2}{U}: Put an hour counter on this artifact.
At the beginning of each upkeep, put an hour counter on this artifact.
When the twelfth hour counter is put on this artifact, shuffle your hand and graveyard into your library, then draw seven cards. Exile this artifact.

Contentious Plan

Experimental Augury

Look at the top three cards of your library. Put one of them into your hand and the rest on the bottom of your library in any order. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Venser, Corpse Puppet

Lifelink, toxic 1
Whenever you proliferate, choose one —
• If you don't control a creature named The Hollow Sentinel, create The Hollow Sentinel, a legendary 3/3 colorless Phyrexian Golem artifact creature token.
• Target artifact creature you control gains flying and lifelink until end of turn.

Night's Whisper

Everflowing Chalice

Multikicker {2} (You may pay an additional {2} any number of times as you cast this spell.)
This artifact enters with a charge counter on it for each time it was kicked.
{T}: Add {C} for each charge counter on this artifact.

Drowned Catacomb

This land enters tapped unless you control an Island or a Swamp.
{T}: Add {U} or {B}.

Plague Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{T}: Add {C}.

Prologue to Phyresis

Each opponent gets a poison counter.
Draw a card.

Negate

Whisper of the Dross

Target creature gets -1/-1 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Arcane Proxy

Prototype {1}{U}{U} — 2/1 (You may cast this spell with different mana cost, color, and size. It keeps its abilities and types.)
When this creature enters, if you cast it, exile target instant or sorcery card with mana value less than or equal to this creature's power from your graveyard. Copy that card. You may cast the copy without paying its mana cost.

Plague Stinger

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Tezzeret's Gambit

({U/P} can be paid with either {U} or 2 life.)
Draw two cards, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Wash Away

Cleave {1}{U}{U} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Counter target spell [that wasn't cast from its owner's hand].

Flux Channeler

Whenever you cast a noncreature spell, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Notion Thief

Flash
If an opponent would draw a card except the first one they draw in each of their draw steps, instead that player skips that draw and you draw a card.

Ichor Rats

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When this creature enters, each player gets a poison counter.

Distorted Curiosity

Corrupted — This spell costs {2} less to cast if an opponent has three or more poison counters.
Draw two cards.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Thrummingbird

Flying
Whenever this creature deals combat damage to a player, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Drown in Ichor

Target creature gets -4/-4 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Dimir Signet

Ash Barrens

{T}: Add {C}.
Basic landcycling {1} ({1}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Sol Ring

Infernal Grasp

Destroy target creature. You lose 2 life.

Phantasmal Image

You may have this creature enter as a copy of any creature on the battlefield, except it's an Illusion in addition to its other types and it has "When this creature becomes the target of a spell or ability, sacrifice it."

Fuel for the Cause

Counter target spell, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Darkwater Catacombs

Glistening Sphere

This artifact enters tapped.
When this artifact enters, proliferate.
{T}: Add one mana of any color.
Corrupted — {T}: Add three mana of any one color. Activate only if an opponent has three or more poison counters.