Typhoid Rats

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Vampiric Rites

{1}{B}, Sacrifice a creature: You gain 1 life and draw a card.

Doom Blade

Reaper's Talisman

Whenever equipped creature attacks, it gains deathtouch until end of turn.
Whenever equipped creature attacks alone, defending player loses 2 life and you gain 2 life.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Merciless Executioner

When Merciless Executioner enters, each player sacrifices a creature of their choice.

Nightmare

Flying (This creature can't be blocked except by creatures with flying or reach.)
Nightmare's power and toughness are each equal to the number of Swamps you control.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Flesh to Dust

Destroy target creature. It can't be regenerated.

Grievous Wound

Enchant player
Enchanted player can't gain life.
Whenever enchanted player is dealt damage, they lose half their life, rounded up.

Taste of Blood

Taste of Blood deals 1 damage to target player or planeswalker and you gain 1 life.

Luxa River Shrine

{1}, {T}: You gain 1 life. Put a brick counter on Luxa River Shrine.
{T}: You gain 2 life. Activate only if there are three or more brick counters on Luxa River Shrine.

Golden Urn

At the beginning of your upkeep, you may put a charge counter on Golden Urn.
{T}, Sacrifice Golden Urn: You gain life equal to the number of charge counters on Golden Urn.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Deathgaze Cockatrice

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Pharika's Cure

Pharika's Cure deals 2 damage to target creature and you gain 2 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Fanatic of the Harrowing

When Fanatic of the Harrowing enters, each player discards a card. If you discarded a card this way, draw a card.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Clawing Torment

Enchant artifact or creature
As long as enchanted permanent is a creature, it gets -1/-1 and can't block.
Enchanted permanent has "At the beginning of your upkeep, you lose 1 life."

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Popular Egotist

{1}{B}, Sacrifice another creature or enchantment: Popular Egotist gains indestructible until end of turn. Tap it. (Damage and effects that say "destroy" don't destroy it.)
Whenever you sacrifice a permanent, target opponent loses 1 life and you gain 1 life.

Angel's Feather

Whenever a player casts a white spell, you may gain 1 life.

Gruesome Realization

Choose one —
• You draw two cards and you lose 2 life.
• Creatures your opponents control get -1/-1 until end of turn.

Douse in Gloom

Douse in Gloom deals 2 damage to target creature and you gain 2 life.

Render Inert

Remove up to five counters from target permanent.
Draw a card.

Rug of Smothering

Flying
Whenever a player casts a spell, they lose 1 life for each spell they've cast this turn.

Metalspinner's Puzzleknot

When Metalspinner's Puzzleknot enters, you draw a card and you lose 1 life.
{2}{B}, Sacrifice Metalspinner's Puzzleknot: You draw a card and you lose 1 life.

Suffocating Fumes

Creatures your opponents control get -1/-1 until end of turn.
Cycling {2} ({2}, Discard this card: Draw a card.)

Spreading Rot

Destroy target land. Its controller loses 2 life.

Rotfeaster Maggot

When Rotfeaster Maggot enters, exile target creature card from a graveyard. You gain life equal to that card's toughness.

Etched Familiar

When Etched Familiar dies, each opponent loses 2 life and you gain 2 life.

You Are Already Dead

Destroy target creature that was dealt damage this turn.
Draw a card.

Offer Immortality

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Bushmeat Poacher

{1}, {T}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness. Draw a card.

Depraved Harvester

Desperate Farmer

Lifelink
When another creature you control dies, transform Desperate Farmer.

Desperate Farmer // Depraved Harvester

Unexpected Fangs

Put a +1/+1 counter and a lifelink counter on target creature.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Corrupt

Corrupt deals damage to any target equal to the number of Swamps you control. You gain life equal to the damage dealt this way.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Unholy Hunger

Destroy target creature.
Spell mastery — If there are two or more instant and/or sorcery cards in your graveyard, you gain 2 life.

Specter of the Fens

Flying
{5}{B}: Target opponent loses 2 life and you gain 2 life.

Phyrexian Gargantua

When Phyrexian Gargantua enters, you draw two cards and you lose 2 life.

Covenant of Blood

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Covenant of Blood deals 4 damage to any target and you gain 4 life.

Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Fatal Fumes

Target creature gets -4/-2 until end of turn.

Serrated Scorpion

When Serrated Scorpion dies, it deals 2 damage to each opponent and you gain 2 life.

Wall of Limbs

Defender (This creature can't attack.)
Whenever you gain life, put a +1/+1 counter on Wall of Limbs.
{5}{B}{B}, Sacrifice Wall of Limbs: Target player loses X life, where X is Wall of Limbs's power.

Urborg Syphon-Mage

{2}{B}, {T}, Discard a card: Each other player loses 2 life. You gain life equal to the life lost this way.

Dross Skullbomb

{1}, Sacrifice Dross Skullbomb: Draw a card.
{2}{B}, Sacrifice Dross Skullbomb: Return target creature card from your graveyard to your hand. Draw a card. Activate only as a sorcery.

Sol Ring

Circuit Mender

When Circuit Mender enters, you gain 2 life.
When Circuit Mender leaves the battlefield, draw a card.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Absorb Vis

Target player loses 4 life and you gain 4 life.
Basic landcycling {1}{B} ({1}{B}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Vrock

Flying
Toxic Spores — At the beginning of your end step, if a permanent you controlled left the battlefield this turn, each opponent loses 3 life.

Infectious Horror

Whenever Infectious Horror attacks, each opponent loses 2 life.

Quag Sickness

Enchant creature
Enchanted creature gets -1/-1 for each Swamp you control.

Murder

Cruel Grimnarch

Deathtouch
When Cruel Grimnarch enters, each opponent discards a card. For each opponent who can't, you gain 4 life.

Prismatic Lens

{T}: Add {C}.
{1}, {T}: Add one mana of any color.

Doomsday Excruciator

Flying
When Doomsday Excruciator enters, if it was cast, each player exiles all but the bottom six cards of their library face down.
At the beginning of your upkeep, draw a card.

Midnight Assassin

Hemlock Vial

When Hemlock Vial enters, you draw a card and you lose 1 life.
{B}, {T}, Sacrifice Hemlock Vial: Each equipped creature and Equipment you control gains deathtouch until end of turn.

Tidy Conclusion

Destroy target creature. You gain 1 life for each artifact you control.

Sign in Blood

Target player draws two cards and loses 2 life.

Swamp

Soulcage Fiend

When Soulcage Fiend dies, each player loses 3 life.

Rush of Vitality

Target creature gets +1/+0 and gains lifelink and indestructible until end of turn. (Damage dealt by that creature also causes its controller to gain that much life, and it can't be destroyed by damage or effects that say "destroy.")

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Painful Lesson

Blood-Toll Harpy

Flying
When Blood-Toll Harpy enters, each player loses 1 life.

Prophetic Prism

When Prophetic Prism enters, draw a card.
{1}, {T}: Add one mana of any color.

Foul-Tongue Shriek

Target opponent loses 1 life for each attacking creature you control. You gain that much life.

Stab Wound

Enchant creature
Enchanted creature gets -2/-2.
At the beginning of the upkeep of enchanted creature's controller, that player loses 2 life.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Fear of Lost Teeth

When Fear of Lost Teeth dies, it deals 1 damage to any target and you gain 1 life.

Grimdancer

Grimdancer enters with your choice of two different counters on it from among menace, deathtouch, and lifelink.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Bladebrand

Target creature gains deathtouch until end of turn.
Draw a card.

The Dross Pits

The Dross Pits enters tapped.
{T}: Add {B}.
{1}{B}, {T}, Sacrifice The Dross Pits: Draw a card.

Bloodhunter Bat

Flying
When Bloodhunter Bat enters, target player loses 2 life and you gain 2 life.