Ambition's Cost

You draw three cards and you lose 3 life.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Expedition Map

{2}, {T}, Sacrifice this artifact: Search your library for a land card, reveal it, put it into your hand, then shuffle.

Don't Have

Pain Seer

Inspired — Whenever this creature becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Corpse Augur

When this creature dies, you draw X cards and you lose X life, where X is the number of creature cards in target player's graveyard.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Dark Ritual

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Priest of Fell Rites

{T}, Pay 3 life, Sacrifice this creature: Return target creature card from your graveyard to the battlefield. Activate only as a sorcery.
Unearth {3}{W}{B} ({3}{W}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Underground River

{T}: Add {C}.
{T}: Add {U} or {B}. This land deals 1 damage to you.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Shattered Sanctum

This land enters tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Mutavault

{T}: Add {C}.
{1}: This land becomes a 2/2 creature with all creature types until end of turn. It's still a land.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Mother of Runes

{T}: Target creature you control gains protection from the color of your choice until end of turn.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Armageddon

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Orzhov Basilica

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Talisman of Dominance

{T}: Add {C}.
{T}: Add {U} or {B}. This artifact deals 1 damage to you.

Arcane Signet

Font of Agonies

Whenever you pay life, put that many blood counters on this enchantment.
{1}{B}, Remove four blood counters from this enchantment: Destroy target creature.

Baleful Strix

Flying, deathtouch
When this creature enters, draw a card.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It is every creature type.)

Midnight Reaper

Whenever a nontoken creature you control dies, this creature deals 1 damage to you and you draw a card.

Pact Weapon

As long as this Equipment is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

River's Rebuke

Return all nonland permanents target player controls to their owner's hand.

Night's Whisper

Stormscape Familiar

Flying
White spells and black spells you cast cost {1} less to cast.

Dimir Aqueduct

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {U}{B}.

Burnished Hart

{3}, Sacrifice this creature: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

City of Brass

Whenever this land becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Island

Deserted Beach

This land enters tapped unless you control two or more other lands.
{T}: Add {W} or {U}.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Siren Stormtamer

Flying
{U}, Sacrifice this creature: Counter target spell or ability that targets you or a creature you control.

Adarkar Wastes

{T}: Add {C}.
{T}: Add {W} or {U}. This land deals 1 damage to you.

Arcane Sanctum

This land enters tapped.
{T}: Add {W}, {U}, or {B}.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Sakashima's Protege

Flash
Cascade (When you cast this spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom in a random order.)
You may have this creature enter as a copy of any permanent that entered this turn.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

The Book of Exalted Deeds

At the beginning of your end step, if you gained 3 or more life this turn, create a 3/3 white Angel creature token with flying.
{W}{W}{W}, {T}, Exile The Book of Exalted Deeds: Put an enlightened counter on target Angel. It gains "You can't lose the game and your opponents can't win the game." Activate only as a sorcery.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Spellskite

{U/P}: Change a target of target spell or ability to this creature. ({U/P} can be paid with either {U} or 2 life.)

Tainted Sigil

{T}, Sacrifice this artifact: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Tyrite Sanctum

{T}: Add {C}.
{2}, {T}: Target legendary creature becomes a God in addition to its other types. Put a +1/+1 counter on it.
{4}, {T}, Sacrifice this land: Put an indestructible counter on target God.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, this artifact deals 3 damage to you.
{T}: Add {C}{C}.

Sun Titan

Vigilance
Whenever this creature enters or attacks, you may return target permanent card with mana value 3 or less from your graveyard to the battlefield.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Judge's Familiar

Flying
Sacrifice this creature: Counter target instant or sorcery spell unless its controller pays {1}.

Skycloud Expanse

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Shriekmaw

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
When this creature enters, destroy target nonartifact, nonblack creature.
Evoke {1}{B} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Fractured Identity

Exile target nonland permanent. Each player other than its controller creates a token that's a copy of it.

Mirror Universe

{T}, Sacrifice this artifact: Exchange life totals with target opponent. Activate only during your upkeep.

Karmic Guide

Flying, protection from black
Echo {3}{W}{W} (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
When this creature enters, return target creature card from your graveyard to the battlefield.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.

Myriad Landscape

This land enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice this land: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Sunken Hollow

({T}: Add {U} or {B}.)
This land enters tapped unless you control two or more basic lands.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Queza, Augur of Agonies

Whenever you draw a card, target opponent loses 1 life and you gain 1 life.

Bane, Lord of Darkness

As long as your life total is less than or equal to half your starting life total, Bane has indestructible.
Whenever another nontoken creature you control dies, target opponent may have you draw a card. If they don't, you may put a creature card with equal or lesser toughness from your hand onto the battlefield.

Goldmire Bridge

This land enters tapped.
Indestructible
{T}: Add {W} or {B}.

Spark Double

You may have this creature enter as a copy of a creature or planeswalker you control, except it enters with an additional +1/+1 counter on it if it's a creature, it enters with an additional loyalty counter on it if it's a planeswalker, and it isn't legendary.

Mulldrifter

Flying
When this creature enters, draw two cards.
Evoke {2}{U} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Ancient Craving

Plains

Esper Panorama

{T}: Add {C}.
{1}, {T}, Sacrifice this land: Search your library for a basic Plains, Island, or Swamp card, put it onto the battlefield tapped, then shuffle.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Flooded Strand

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Island card, put it onto the battlefield, then shuffle.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Port Town

As this land enters, you may reveal a Plains or Island card from your hand. If you don't, this land enters tapped.
{T}: Add {W} or {U}.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Shipwreck Marsh

This land enters tapped unless you control two or more other lands.
{T}: Add {U} or {B}.

Temple of Silence

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {W} or {B}.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Gilded Lotus

Forceful Denial

Cascade (When you cast this spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom in a random order.)
Counter target spell.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.