Thermo-Alchemist

Defender
{T}: Thermo-Alchemist deals 1 damage to each opponent.
Whenever you cast an instant or sorcery spell, untap Thermo-Alchemist.

Kalamax, the Stormsire

Whenever you cast your first instant spell each turn, if Kalamax, the Stormsire is tapped, copy that spell. You may choose new targets for the copy.
Whenever you copy an instant spell, put a +1/+1 counter on Kalamax.

Pyroconvergence

Whenever you cast a multicolored spell, Pyroconvergence deals 2 damage to any target.

Dovin's Acuity

When Dovin's Acuity enters, you gain 2 life and draw a card.
Whenever you cast an instant spell during your main phase, you may return Dovin's Acuity to its owner's hand.

Rampaging Monument

Trample
Rampaging Monument enters with three +1/+1 counters on it.
Whenever you cast a multicolored spell, put a +1/+1 counter on Rampaging Monument.

Ovika, Enigma Goliath

Flying
Ward—{3}, Pay 3 life.
Whenever you cast a noncreature spell, create X 1/1 red Phyrexian Goblin creature tokens, where X is the mana value of that spell. They gain haste until end of turn.

Rockslide Sorcerer

Whenever you cast an instant, sorcery, or Wizard spell, Rockslide Sorcerer deals 1 damage to any target.

Rona, Sheoldred's Faithful

Whenever you cast an instant or sorcery spell, each opponent loses 1 life.
You may cast Rona, Sheoldred's Faithful from your graveyard by discarding two cards in addition to paying its other costs.

Metallurgic Summonings

Whenever you cast an instant or sorcery spell, create an X/X colorless Construct artifact creature token, where X is that spell's mana value.
{3}{U}{U}, Exile Metallurgic Summonings: Return all instant and sorcery cards from your graveyard to your hand. Activate only if you control six or more artifacts.

Saheeli, Sublime Artificer

Whenever you cast a noncreature spell, create a 1/1 colorless Servo artifact creature token.
−2: Target artifact you control becomes a copy of another target artifact or creature you control until end of turn, except it's an artifact in addition to its other types.

All Suns' Dawn

For each color, return up to one target card of that color from your graveyard to your hand. Exile All Suns' Dawn.

Archmage Emeritus

Magecraft — Whenever you cast or copy an instant or sorcery spell, draw a card.

Kykar, Wind's Fury

Flying
Whenever you cast a noncreature spell, create a 1/1 white Spirit creature token with flying.
Sacrifice a Spirit: Add {R}.

Whispering Wizard

Whenever you cast a noncreature spell, create a 1/1 white Spirit creature token with flying. This ability triggers only once each turn.

Whirlwind of Thought

Whenever you cast a noncreature spell, draw a card.

Melek, Izzet Paragon

Play with the top card of your library revealed.
You may cast instant and sorcery spells from the top of your library.
Whenever you cast an instant or sorcery spell from your library, copy it. You may choose new targets for the copy.

Gale, Waterdeep Prodigy

Whenever you cast an instant or sorcery spell from your hand, you may cast up to one target card of the other type from your graveyard. If a spell cast from your graveyard this way would be put into your graveyard, exile it instead.
Choose a Background (You can have a Background as a second commander.)

Ral, Storm Conduit

Whenever you cast or copy an instant or sorcery spell, Ral, Storm Conduit deals 1 damage to target opponent or planeswalker.
+2: Scry 1.
−2: When you next cast an instant or sorcery spell this turn, copy that spell. You may choose new targets for the copy.

Chromatic Orrery

You may spend mana as though it were mana of any color.
{T}: Add {C}{C}{C}{C}{C}.
{5}, {T}: Draw a card for each color among permanents you control.

Serum Sovereign

Flying
Whenever you cast a noncreature spell, put an oil counter on Serum Sovereign.
{U}, Remove an oil counter from Serum Sovereign: Draw a card, then scry 2.

Murmuring Mystic

Whenever you cast an instant or sorcery spell, create a 1/1 blue Bird Illusion creature token with flying.

Pink Horror

Coruscating Flames — Whenever you cast an instant or sorcery spell, Pink Horror deals 2 damage to any target.
Split — When Pink Horror dies, create two 2/2 blue and red Demon Horror creature tokens named Blue Horror with "Whenever you cast an instant or sorcery spell, this creature deals 1 damage to any target."

Mana Cannons

Whenever you cast a multicolored spell, Mana Cannons deals X damage to any target, where X is the number of colors that spell is.

Firebrand Archer

Whenever you cast a noncreature spell, this creature deals 1 damage to each opponent.

General Ferrous Rokiric

Hexproof from monocolored
Whenever you cast a multicolored spell, create a 4/4 red and white Golem artifact creature token.

The Mana Rig

Whenever you cast a multicolored spell, create a tapped Powerstone token. (It's an artifact with "{T}: Add {C}. This mana can't be spent to cast a nonartifact spell.")
{X}{X}{X}, {T}: Look at the top X cards of your library. Put up to two of them into your hand and the rest on the bottom of your library in a random order.

Ramos, Dragon Engine

Flying
Whenever you cast a spell, put a +1/+1 counter on Ramos for each of that spell's colors.
Remove five +1/+1 counters from Ramos: Add {W}{W}{U}{U}{B}{B}{R}{R}{G}{G}. Activate only once each turn.

Hero of Precinct One

Whenever you cast a multicolored spell, create a 1/1 white Human creature token.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Monastery Mentor

Prowess (Whenever you cast a noncreature spell, this creature gets +1/+1 until end of turn.)
Whenever you cast a noncreature spell, create a 1/1 white Monk creature token with prowess.

Gelectrode

{T}: Gelectrode deals 1 damage to any target.
Whenever you cast an instant or sorcery spell, you may untap Gelectrode.

Goblinslide

Whenever you cast a noncreature spell, you may pay {1}. If you do, create a 1/1 red Goblin creature token with haste.

Kessig Flamebreather

Whenever you cast a noncreature spell, Kessig Flamebreather deals 1 damage to each opponent.

Lunar Mystic

Whenever you cast an instant spell, you may pay {1}. If you do, draw a card.

Urza's Filter

Multicolored spells cost {2} less to cast.

Electrostatic Field

Defender
Whenever you cast an instant or sorcery spell, Electrostatic Field deals 1 damage to each opponent.

Young Pyromancer

Whenever you cast an instant or sorcery spell, create a 1/1 red Elemental creature token.

Thousand-Year Storm

Whenever you cast an instant or sorcery spell, copy it for each other instant and sorcery spell you've cast before it this turn. You may choose new targets for the copies.

Jace's Sanctum

Instant and sorcery spells you cast cost {1} less to cast.
Whenever you cast an instant or sorcery spell, scry 1.

Epic Experiment

Exile the top X cards of your library. You may cast instant and sorcery spells with mana value X or less from among them without paying their mana costs. Then put all cards exiled this way that weren't cast into your graveyard.

Tura Kennerüd, Skyknight

Flying
Whenever you cast an instant or sorcery spell, create a 1/1 white Soldier creature token.

Obsidian Obelisk

Obsidian Obelisk enters tapped.
{T}: Add {C}.
{T}: Add one mana of any color. Spend this mana only to cast a multicolored spell.

Tome of the Guildpact

Whenever you cast a multicolored spell, draw a card.
{T}: Add one mana of any color.

Skywise Teachings

Whenever you cast a noncreature spell, you may pay {1}{U}. If you do, create a 2/2 blue Djinn Monk creature token with flying.

Guttersnipe

Whenever you cast an instant or sorcery spell, this creature deals 2 damage to each opponent.

Cloven Casting

Whenever you cast a multicolored instant or sorcery spell, you may pay {1}. If you do, copy that spell. You may choose new targets for the copy.

Karok Wrangler

Magecraft — Whenever you cast or copy an instant or sorcery spell, put a +1/+1 counter on target creature you control.

Lambholt Ravager

Whenever you cast a noncreature spell, Lambholt Ravager deals 2 damage to each opponent.
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Lambholt Raconteur

Whenever you cast a noncreature spell, Lambholt Raconteur deals 1 damage to each opponent.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Lambholt Raconteur // Lambholt Ravager

Third Path Iconoclast

Whenever you cast a noncreature spell, create a 1/1 colorless Soldier artifact creature token.

Niv-Mizzet, Parun

This spell can't be countered.
Flying
Whenever you draw a card, Niv-Mizzet, Parun deals 1 damage to any target.
Whenever a player casts an instant or sorcery spell, you draw a card.

Pillar of the Paruns

{T}: Add one mana of any color. Spend this mana only to cast a multicolored spell.

Witherbloom Apprentice

Magecraft — Whenever you cast or copy an instant or sorcery spell, each opponent loses 1 life and you gain 1 life.

Talrand, Sky Summoner

Whenever you cast an instant or sorcery spell, create a 2/2 blue Drake creature token with flying.