Countersquall

Counter target noncreature spell. Its controller loses 2 life.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Pooling Venom

Enchant land
Whenever enchanted land becomes tapped, its controller loses 2 life.
{3}{B}: Destroy enchanted land.

Kokusho, the Evening Star

Flying
When Kokusho, the Evening Star dies, each opponent loses 5 life. You gain life equal to the life lost this way.

Marsh Gas

All creatures get -2/-0 until end of turn.

Sign in Blood

Target player draws two cards and loses 2 life.

Island

Vampire's Kiss

Target player loses 2 life and you gain 2 life. Create two Blood tokens. (They're artifacts with "{1}, {T}, Discard a card, Sacrifice this artifact: Draw a card.")

Marchesa's Decree

When Marchesa's Decree enters, you become the monarch.
Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Tyrant's Scorn

Choose one —
• Destroy target creature with mana value 3 or less.
• Return target creature to its owner's hand.

Dragon Turtle

Flash
Drag Below — When Dragon Turtle enters, tap it and up to one target creature an opponent controls. They don't untap during their controllers' next untap steps.

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Damnable Pact

Target player draws X cards and loses X life.

Contaminated Ground

Enchant land
Enchanted land is a Swamp.
Whenever enchanted land becomes tapped, its controller loses 2 life.

Parasitic Impetus

Enchant creature
Enchanted creature gets +2/+2 and is goaded. (It attacks each combat if able and attacks a player other than you if able.)
Whenever enchanted creature attacks, its controller loses 2 life and you gain 2 life.

Iymrith, Desert Doom

Flying
Iymrith, Desert Doom has ward {4} as long as it's untapped.
Whenever Iymrith deals combat damage to a player, draw a card. Then if you have fewer than three cards in hand, draw cards equal to the difference.

Undermine

Counter target spell. Its controller loses 3 life.

Stab Wound

Enchant creature
Enchanted creature gets -2/-2.
At the beginning of the upkeep of enchanted creature's controller, that player loses 2 life.

Painful Lesson

Blood Pact

Sivitri, Dragon Master

+1: Until your next turn, creatures can't attack you or planeswalkers you control unless their controller pays 2 life for each of those creatures.
−3: Search your library for a Dragon card, reveal it, put it into your hand, then shuffle.
−7: Destroy all non-Dragon creatures.
Sivitri, Dragon Master can be your commander.

Ebondeath, Dracolich

Flash
Flying
Ebondeath, Dracolich enters tapped.
You may cast Ebondeath, Dracolich from your graveyard if a creature not named Ebondeath, Dracolich died this turn.

Junji, the Midnight Sky

Flying, menace
When Junji, the Midnight Sky dies, choose one —
• Each opponent discards two cards and loses 2 life.
• Put target non-Dragon creature card from a graveyard onto the battlefield under your control. You lose 2 life.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Juvenile Mist Dragon

Flying
Confounding Clouds — When Juvenile Mist Dragon enters, for each opponent, tap up to one target creature that player controls. Each of those creatures doesn't untap during its controller's next untap step.

Hissing Miasma

Whenever a creature attacks you, its controller loses 1 life.

Boneyard Scourge

Flying
Whenever a Dragon you control dies while Boneyard Scourge is in your graveyard, you may pay {1}{B}. If you do, return Boneyard Scourge from your graveyard to the battlefield.

Forsaken Wastes

Players can't gain life.
At the beginning of each player's upkeep, that player loses 1 life.
Whenever Forsaken Wastes becomes the target of a spell, that spell's controller loses 5 life.

Keiga, the Tide Star

Flying
When Keiga, the Tide Star dies, gain control of target creature.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Dragonlord Silumgar

Flying, deathtouch
When Dragonlord Silumgar enters, gain control of target creature or planeswalker for as long as you control Dragonlord Silumgar.

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Clutch of the Undercity

Return target permanent to its owner's hand. Its controller loses 3 life.
Transmute {1}{U}{B} ({1}{U}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then shuffle. Transmute only as a sorcery.)

Skithiryx, the Blight Dragon

Flying
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{B}: Skithiryx, the Blight Dragon gains haste until end of turn.
{B}{B}: Regenerate Skithiryx.

Swamp

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Corrupted Roots

Enchant Forest or Plains
Whenever enchanted land becomes tapped, its controller loses 2 life.

Insubordination

Enchant creature
At the beginning of the end step of enchanted creature's controller, Insubordination deals 2 damage to that player unless that creature attacked this turn.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Blood Reckoning

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Sovereign's Bite

Target player loses 3 life and you gain 3 life.

Sinister Possession

Enchant creature
Whenever enchanted creature attacks or blocks, its controller loses 2 life.

Kairi, the Swirling Sky

Flying, ward {3}
When Kairi, the Swirling Sky dies, choose one —
• Return any number of target nonland permanents with total mana value 6 or less to their owners' hands.
• Mill six cards, then return up to two instant and/or sorcery cards from your graveyard to your hand.

Contaminated Bond

Enchant creature (Target a creature as you cast this. This card enters attached to that creature.)
Whenever enchanted creature attacks or blocks, its controller loses 3 life.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Necromaster Dragon

Flying
Whenever Necromaster Dragon deals combat damage to a player, you may pay {2}. If you do, create a 2/2 black Zombie creature token and each opponent mills two cards.

Ragged Veins

Flash
Enchant creature
Whenever enchanted creature is dealt damage, its controller loses that much life.

Lithoform Blight

Enchant land
When Lithoform Blight enters, draw a card.
Enchanted land loses all land types and abilities and has "{T}: Add {C}" and "{T}, Pay 1 life: Add one mana of any color."