Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Guul Draz Specter

Flying
This creature gets +3/+3 as long as an opponent has no cards in hand.
Whenever this creature deals combat damage to a player, that player discards a card.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on this enchantment.
At the beginning of each opponent's upkeep, if that player has no cards in hand and this enchantment has two or more quest counters on it, you may have that player lose 5 life.

Snuff Out

If you control a Swamp, you may pay 4 life rather than pay this spell's mana cost.
Destroy target nonblack creature. It can't be regenerated.

Hymn to Tourach

Target player discards two cards at random.

Court of Ambition

When this enchantment enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Swamp

The Rack

As this artifact enters, choose an opponent.
At the beginning of the chosen player's upkeep, this artifact deals X damage to that player, where X is 3 minus the number of cards in their hand.

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Necrogen Spellbomb

{B}, Sacrifice this artifact: Target player discards a card.
{1}, Sacrifice this artifact: Draw a card.

Prickle Faeries

Flying
At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, this creature deals 2 damage to them.

Invasion of Eldraine

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When this Siege enters, target opponent discards two cards.

Invasion of Eldraine // Prickle Faeries

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This token can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Noetic Scales

At the beginning of each player's upkeep, return to its owner's hand each creature that player controls with power greater than the number of cards in their hand.

Crucible of Worlds

Sign in Blood

Target player draws two cards and loses 2 life.

Plaguecrafter

When this creature enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Night's Whisper

Doom Blade

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

No Mercy

Whenever a creature deals damage to you, destroy it.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip this creature.

Nezumi Shortfang // Stabwhisker the Odious

Wheel of Torture

At the beginning of each opponent's upkeep, this artifact deals X damage to that player, where X is 3 minus the number of cards in their hand.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Go for the Throat

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• This creature deals 2 damage to any target and you gain 2 life.

Ensnaring Bridge

Creatures with power greater than the number of cards in your hand can't attack.

Go Blank

Target player discards two cards. Then exile that player's graveyard.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Hypnotic Specter

Flying
Whenever this creature deals damage to an opponent, that player discards a card at random.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Leyline of the Void

If this card is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Extract the Truth

Choose one —
• Target opponent reveals their hand. You may choose a creature, enchantment, or planeswalker card from it. That player discards that card.
• Target opponent sacrifices an enchantment of their choice.

Funeral Charm

Choose one —
• Target player discards a card.
• Target creature gets +2/-1 until end of turn.
• Target creature gains swampwalk until end of turn. (It can't be blocked as long as defending player controls a Swamp.)