Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Greed

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Dark Ritual

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Blood Pact

Target player draws two cards and loses 2 life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures of their choice.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Damnation

Destroy all creatures. They can't be regenerated.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Sign in Blood

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Go for the Throat

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Anvil of Bogardan

Players have no maximum hand size.
At the beginning of each player's draw step, that player draws an additional card, then discards a card.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Sol Ring

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Ancient Craving

You draw three cards and you lose 3 life.

Jet Medallion

Black spells you cast cost {1} less to cast.

Painful Lesson

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Temple Bell

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Horn of Greed

Whenever a player plays a land, that player draws a card.

Ugin, the Spirit Dragon

+2: Ugin, the Spirit Dragon deals 3 damage to any target.
−X: Exile each permanent with mana value X or less that's one or more colors.
−10: You gain 7 life, draw seven cards, then put up to seven permanent cards from your hand onto the battlefield.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Font of Mythos

At the beginning of each player's draw step, that player draws two additional cards.

Profane Tutor

Suspend 2—{1}{B} (Rather than cast this card from your hand, pay {1}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Search your library for a card, put that card into your hand, then shuffle.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Damnable Pact

Target player draws X cards and loses X life.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.