Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Witch's Cauldron

{1}{B}, {T}, Sacrifice a creature: You gain 1 life and draw a card.

Phthisis

Destroy target creature. Its controller loses life equal to its power plus its toughness.
Suspend 5—{1}{B} (Rather than cast this card from your hand, you may pay {1}{B} and exile it with five time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Gríma Wormtongue

Your opponents can't gain life.
{T}, Sacrifice another creature: Target player loses 1 life. If the sacrificed creature was legendary, amass Orcs 2.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Palace Siege

As Palace Siege enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Massacre Girl

Menace
When Massacre Girl enters, each other creature gets -1/-1 until end of turn. Whenever a creature dies this turn, each creature other than Massacre Girl gets -1/-1 until end of turn.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Swamp

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Netherborn Phalanx

When Netherborn Phalanx enters, each opponent loses 1 life for each creature they control.
Transmute {1}{B}{B} ({1}{B}{B}, Discard this card: Search your library for a card with the same mana value as this card, reveal it, put it into your hand, then then shuffle. Transmute only as a sorcery.)

Barren Moor

Barren Moor enters tapped.
{T}: Add {B}.
Cycling {B} ({B}, Discard this card: Draw a card.)

Archfiend of the Dross

Flying
Archfiend of the Dross enters with four oil counters on it.
At the beginning of your upkeep, remove an oil counter from Archfiend of the Dross. Then if it has no oil counters on it, you lose the game.
Whenever a creature an opponent controls dies, its controller loses 2 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Xathrid Demon

Flying, trample
At the beginning of your upkeep, sacrifice a creature other than Xathrid Demon, then each opponent loses life equal to the sacrificed creature's power. If you can't sacrifice a creature, tap Xathrid Demon and you lose 7 life.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Sign in Blood

Target player draws two cards and loses 2 life.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Thieving Amalgam

At the beginning of each opponent's upkeep, you manifest the top card of that player's library. (Put it onto the battlefield face down as a 2/2 creature. Turn it face up any time for its mana cost if it's a creature card.)
Whenever a creature you control but don't own dies, its owner loses 2 life and you gain 2 life.

Hissing Miasma

Whenever a creature attacks you, its controller loses 1 life.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Chainer's Torment

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I, II — Chainer's Torment deals 2 damage to each opponent and you gain 2 life.
III — Create an X/X black Nightmare Horror creature token, where X is half your life total, rounded up. It deals X damage to you.

Thought Vessel

Soot Imp

Flying
Whenever a player casts a nonblack spell, that player loses 1 life.

Scavenger Grounds

{T}: Add {C}.
{2}, {T}, Sacrifice a Desert: Exile all graveyards.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Vermin Gorger

{T}, Sacrifice another creature: Each opponent loses 2 life and you gain 2 life.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Retreat to Hagra

Landfall — Whenever a land you control enters, choose one —
• Target creature gets +1/+0 and gains deathtouch until end of turn.
• Each opponent loses 1 life and you gain 1 life.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Tragic Slip

Target creature gets -1/-1 until end of turn.
Morbid — That creature gets -13/-13 until end of turn instead if a creature died this turn.

Bishop of the Bloodstained

When Bishop of the Bloodstained enters, target opponent loses 1 life for each Vampire you control.

Bastion of Remembrance

When Bastion of Remembrance enters, create a 1/1 white Human Soldier creature token.
Whenever a creature you control dies, each opponent loses 1 life and you gain 1 life.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Caged Zombie

{1}{B}, {T}: Each opponent loses 2 life. Activate only if a creature died this turn.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Soul Shatter

Each opponent sacrifices a creature or planeswalker with the highest mana value among creatures and planeswalkers they control.

Creeping Dread

At the beginning of your upkeep, each player discards a card. Each opponent who discarded a card that shares a card type with the card you discarded loses 3 life. (Players reveal the discarded cards simultaneously.)

Thrull Parasite

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
{T}, Pay 2 life: Remove a counter from target nonland permanent.

Nightshade Harvester

Whenever a land an opponent controls enters, that player loses 1 life. Put a +1/+1 counter on Nightshade Harvester.

Dusk Mangler

As an additional cost to cast this spell, sacrifice a creature, discard a card, or pay 4 life.
When Dusk Mangler enters, each opponent sacrifices a creature of their choice, discards a card, and loses 4 life.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Hierophant's Chalice

When Hierophant's Chalice enters, target opponent loses 1 life and you gain 1 life.
{T}: Add {C}.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Infernal Idol

{T}: Add {B}.
{1}{B}{B}, {T}, Sacrifice Infernal Idol: You draw two cards and you lose 2 life.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Gix's Command

Choose two —
• Put two +1/+1 counters on up to one creature. It gains lifelink until end of turn.
• Destroy each creature with power 2 or less.
• Return up to two creature cards from your graveyard to your hand.
• Each opponent sacrifices a creature with the highest power among creatures they control.

Bontu the Glorified

Menace, indestructible
Bontu the Glorified can't attack or block unless a creature died under your control this turn.
{1}{B}, Sacrifice another creature: Scry 1. Each opponent loses 1 life and you gain 1 life.

Kheru Bloodsucker

Whenever a creature you control with toughness 4 or greater dies, each opponent loses 2 life and you gain 2 life.
{2}{B}, Sacrifice another creature: Put a +1/+1 counter on Kheru Bloodsucker.

Falkenrath Noble

Flying
Whenever Falkenrath Noble or another creature dies, target player loses 1 life and you gain 1 life.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Calculating Lich

Menace
Whenever a creature attacks one of your opponents, that player loses 1 life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Baneful Omen

At the beginning of your end step, you may reveal the top card of your library. If you do, each opponent loses life equal to that card's mana value.

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Blood Reckoning

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life.

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Thran Dynamo

Sivriss, Nightmare Speaker

{T}, Sacrifice another creature or an artifact: For each opponent, you mill a card, then return that card from your graveyard to your hand unless that player pays 3 life. (To mill a card, put the top card of your library into your graveyard.)
Choose a Background (You can have a Background as a second commander.)

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Servant of Tymaret

Inspired — Whenever Servant of Tymaret becomes untapped, each opponent loses 1 life. You gain life equal to the life lost this way.
{2}{B}: Regenerate Servant of Tymaret.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Epicure of Blood

Meteor Golem

When this creature enters, destroy target nonland permanent an opponent controls.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Night's Whisper

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

High Market

{T}: Add {C}.
{T}, Sacrifice a creature: You gain 1 life.

Grave Endeavor

Roll two d10 and choose one result. Return a creature card from your graveyard to the battlefield with a number of +1/+1 counters on it equal to that result. Then each opponent loses X life and you gain X life, where X is the other result.

Memorial to Folly

Memorial to Folly enters tapped.
{T}: Add {B}.
{2}{B}, {T}, Sacrifice Memorial to Folly: Return target creature card from your graveyard to your hand.

Dingus Staff

Whenever a creature dies, Dingus Staff deals 2 damage to that creature's controller.

Parasitic Impetus

Enchant creature
Enchanted creature gets +2/+2 and is goaded. (It attacks each combat if able and attacks a player other than you if able.)
Whenever enchanted creature attacks, its controller loses 2 life and you gain 2 life.

Dark Suspicions

At the beginning of each opponent's upkeep, that player loses X life, where X is the number of cards in that player's hand minus the number of cards in your hand.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Patron of the Nezumi

Rat offering (You may cast this spell any time you could cast an instant by sacrificing a Rat and paying the difference in mana costs between this and the sacrificed Rat. Mana cost includes color.)
Whenever a permanent is put into an opponent's graveyard, that player loses 1 life.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Ill-Gotten Inheritance

At the beginning of your upkeep, Ill-Gotten Inheritance deals 1 damage to each opponent and you gain 1 life.
{5}{B}, Sacrifice Ill-Gotten Inheritance: It deals 4 damage to target opponent and you gain 4 life.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Liability

Whenever a nontoken permanent is put into a player's graveyard from the battlefield, that player loses 1 life.

Siege Zombie

Tap three untapped creatures you control: Each opponent loses 1 life.

Dreg Recycler

{T}, Sacrifice an artifact or creature: Each opponent loses 1 life and you gain 1 life.

Vrock

Flying
Toxic Spores — At the beginning of your end step, if a permanent you controlled left the battlefield this turn, each opponent loses 3 life.

Go for the Throat

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Battlefield Butcher

{5}, {T}: Each opponent loses 2 life. This ability costs {1} less to activate for each creature card in your graveyard.