Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Gideon of the Trials

+1: Until your next turn, prevent all damage target permanent would deal.
0: Until end of turn, Gideon becomes a 4/4 Human Soldier creature with indestructible that's still a planeswalker. Prevent all damage that would be dealt to him this turn.
0: You get an emblem with "As long as you control a Gideon planeswalker, you can't lose the game and your opponents can't win the game."

Sign in Blood

Target player draws two cards and loses 2 life.

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Swamp

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy this enchantment. You skip your next turn. Any player may activate this ability.

Moon-Blessed Cleric

Divine Intervention — When this creature enters, you may search your library for an enchantment card, reveal it, then shuffle and put that card on top.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Legions to Ashes

Exile target nonland permanent an opponent controls and all tokens that player controls with the same name as that permanent.

Plains

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Piranha Marsh

This land enters tapped.
When this land enters, target player loses 1 life.
{T}: Add {B}.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Urza's Cave

{T}: Add {C}.
{3}, {T}, Sacrifice this land: Search your library for a land card, put it onto the battlefield tapped, then shuffle.

Magus of the Coffers

Orim's Chant

Kicker {W} (You may pay an additional {W} as you cast this spell.)
Target player can't cast spells this turn. If this spell was kicked, creatures can't attack this turn.

Boggart Bog

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.

Boggart Trawler

When this creature enters, exile target player's graveyard.

Boggart Trawler // Boggart Bog

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Scoured Barrens

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {W} or {B}.

Solitude

Flash
Lifelink
When this creature enters, exile up to one other target creature. That creature's controller gains life equal to its power.
Evoke—Exile a white card from your hand.

Soul Echo

This enchantment enters with X echo counters on it.
You don't lose the game for having 0 or less life.
At the beginning of your upkeep, sacrifice this enchantment if there are no echo counters on it. Otherwise, target opponent may choose that for each 1 damage that would be dealt to you until your next upkeep, you remove an echo counter from this enchantment instead.

Damnable Pact

Target player draws X cards and loses X life.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Hagra Broodpit

Hagra Mauling

This spell costs {1} less to cast if an opponent controls no basic lands.
Destroy target creature.

Hagra Mauling // Hagra Broodpit

Fell Mire

Fell the Profane

Fell the Profane // Fell Mire

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Sunscorched Desert

When this land enters, it deals 1 damage to target player or planeswalker.
{T}: Add {C}.

Orzhova, the Church of Deals

{T}: Add {C}.
{3}{W}{B}, {T}: Target player loses 1 life and you gain 1 life.

Diabolic Tutor

Blood Pact

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Sol Ring

Salt Flats

This land enters tapped.
{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Grand Coliseum

This land enters tapped.
{T}: Add {C}.
{T}: Add one mana of any color. This land deals 1 damage to you.

Mana Tithe

Counter target spell unless its controller pays {1}.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When this land enters, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Reprieve

Return target spell to its owner's hand.
Draw a card.

Herald of Eternal Dawn

Flash (You may cast this spell any time you could cast an instant.)
Flying
You can't lose the game and your opponents can't win the game.

Fountain of Cho

This land enters tapped.
{T}: Put a storage counter on this land.
{T}, Remove any number of storage counters from this land: Add {W} for each storage counter removed this way.

Leechridden Swamp

({T}: Add {B}.)
This land enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Bottomless Vault

This land enters tapped.
You may choose not to untap this land during your untap step.
At the beginning of your upkeep, if this land is tapped, put a storage counter on it.
{T}, Remove any number of storage counters from this land: Add {B} for each storage counter removed this way.

Glasses of Urza

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Pelakka Caverns

Pelakka Predation

Target opponent reveals their hand. You choose a card from it with mana value 3 or greater. That player discards that card.

Pelakka Predation // Pelakka Caverns

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Myriad Landscape

This land enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice this land: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Boseiju, Who Shelters All

Boseiju enters tapped.
{T}, Pay 2 life: Add {C}. If that mana is spent on an instant or sorcery spell, that spell can't be countered.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia to its owner's hand.

Tainted Sigil

{T}, Sacrifice this artifact: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Orzhov Signet

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Profane Tutor

Suspend 2—{1}{B} (Rather than cast this card from your hand, pay {1}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Search your library for a card, put that card into your hand, then shuffle.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Weathered Wayfarer

{W}, {T}: Search your library for a land card, reveal it, put it into your hand, then shuffle. Activate only if an opponent controls more lands than you.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Inquisition of Kozilek

Target player reveals their hand. You choose a nonland card from it with mana value 3 or less. That player discards that card.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is this creature's power.

Lapse of Certainty

Counter target spell. If that spell is countered this way, put it on top of its owner's library instead of into that player's graveyard.

Orzhov Basilica

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Mage-Ring Network

{T}: Add {C}.
{1}, {T}: Put a storage counter on this land.
{T}, Remove any number of storage counters from this land: Add {C} for each storage counter removed this way.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Maralen of the Mornsong

Players can't draw cards.
At the beginning of each player's draw step, that player loses 3 life, searches their library for a card, puts it into their hand, then shuffles.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Cruel Tutor

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

The Book of Exalted Deeds

At the beginning of your end step, if you gained 3 or more life this turn, create a 3/3 white Angel creature token with flying.
{W}{W}{W}, {T}, Exile The Book of Exalted Deeds: Put an enlightened counter on target Angel. It gains "You can't lose the game and your opponents can't win the game." Activate only as a sorcery.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Drannith Magistrate

Your opponents can't cast spells from anywhere other than their hands.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Thran Dynamo

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. This artifact deals 1 damage to you.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Illumination

Counter target artifact or enchantment spell. Its controller gains life equal to its mana value.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Vedalken Orrery

You may cast spells as though they had flash.

Cloudsteel Kirin

Flying
Equipped creature has flying and "You can't lose the game and your opponents can't win the game."
Reconfigure {5} ({5}: Attach to target creature you control; or unattach from a creature. Reconfigure only as a sorcery. While attached, this isn't a creature.)

Wayfarer's Bauble

{2}, {T}, Sacrifice this artifact: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Emergence Zone

{T}: Add {C}.
{1}, {T}, Sacrifice this land: You may cast spells this turn as though they had flash.

Aven Interrupter

Flash
Flying
When this creature enters, exile target spell. It becomes plotted. (Its owner may cast it as a sorcery on a later turn without paying its mana cost.)
Spells your opponents cast from graveyards or from exile cost {2} more to cast.