Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Shriveling Rot

Choose one —
• Until end of turn, whenever a creature is dealt damage, destroy it.
• Until end of turn, whenever a creature dies, that creature's controller loses life equal to its toughness.
Entwine {2}{B} (Choose both if you pay the entwine cost.)

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Jinxed Idol

At the beginning of your upkeep, this artifact deals 2 damage to you.
Sacrifice a creature: Target opponent gains control of this artifact.

Saw in Half

Destroy target creature. If that creature dies this way, its controller creates two tokens that are copies of that creature, except their power is half that creature's power and their toughness is half that creature's toughness. Round up each time.

Orzhov Basilica

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Gollum, Obsessed Stalker

Skulk (This creature can't be blocked by creatures with greater power.)
At the beginning of your end step, each opponent dealt combat damage this game by a creature named Gollum, Obsessed Stalker loses life equal to the amount of life you gained this turn.

Angelic Purge

As an additional cost to cast this spell, sacrifice a permanent.
Exile target artifact, creature, or enchantment.

Marionette Master

Fabricate 3 (When this creature enters, put three +1/+1 counters on it or create three 1/1 colorless Servo artifact creature tokens.)
Whenever an artifact you control is put into a graveyard from the battlefield, target opponent loses life equal to this creature's power.

Oath of Lim-Dûl

Whenever you lose life, for each 1 life you lost, sacrifice a permanent other than this enchantment unless you discard a card. (Damage dealt to you causes you to lose life.)
{B}{B}: Draw a card.

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Plains

Curse of Vengeance

Enchant player
Whenever enchanted player casts a spell, put a spite counter on this Aura.
When enchanted player loses the game, you gain X life and draw X cards, where X is the number of spite counters on this Aura.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Underhanded Designs

Whenever an artifact you control enters, you may pay {1}. If you do, each opponent loses 1 life and you gain 1 life.
{1}{B}, Sacrifice this enchantment: Destroy target creature. Activate only if you control two or more artifacts.

Sengir, the Dark Baron

Flying
Whenever another creature dies, put two +1/+1 counters on Sengir.
Whenever another player loses the game, you gain life equal to that player's life total as the turn began.
Partner (You can have two commanders if both have partner.)

Dark Bargain

Look at the top three cards of your library. Put two of them into your hand and the other into your graveyard. Dark Bargain deals 2 damage to you.

Angel of Grace

Flash
Flying
When this creature enters, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile this card from your graveyard: Your life total becomes 10.

Measure of Wickedness

At the beginning of your end step, sacrifice this enchantment and you lose 8 life.
Whenever another card is put into your graveyard from anywhere, target opponent gains control of this enchantment.

Lobelia, Defender of Bag End

When Lobelia enters, look at the top card of each opponent's library and exile those cards face down.
{T}, Sacrifice an artifact: Choose one —
• Until end of turn, you may play a card exiled with Lobelia without paying its mana cost.
• Each opponent loses 2 life and you gain 2 life.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Oust

Put target creature into its owner's library second from the top. Its controller gains 3 life.

Phyrexian Processor

As this artifact enters, pay any amount of life.
{4}, {T}: Create an X/X black Phyrexian Minion creature token, where X is the life paid as this artifact entered.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Ragged Veins

Flash
Enchant creature
Whenever enchanted creature is dealt damage, its controller loses that much life.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Fateful Handoff

Draw cards equal to the mana value of target artifact or creature you control. An opponent gains control of that permanent.

Rosie Cotton of South Lane

When Rosie Cotton enters, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
Whenever you create a token, put a +1/+1 counter on target creature you control other than Rosie Cotton.

Sol Ring

Night's Whisper

Agent of the Iron Throne

Commander creatures you own have "Whenever an artifact or creature you control is put into a graveyard from the battlefield, each opponent loses 1 life."

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Bloodtracker

Flying
{B}, Pay 2 life: Put a +1/+1 counter on this creature.
When this creature leaves the battlefield, draw a card for each +1/+1 counter on it.

Mausoleum Secrets

Undergrowth — Search your library for a black card with mana value less than or equal to the number of creature cards in your graveyard, reveal it, put it into your hand, then shuffle.

Ebonblade Reaper

Whenever this creature attacks, you lose half your life, rounded up.
Whenever this creature deals combat damage to a player, that player loses half their life, rounded up.
Morph {3}{B}{B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Rhystic Tutor

Unless any player pays {2}, search your library for a card, put that card into your hand, then shuffle.

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Sunlit Marsh

({T}: Add {W} or {B}.)
This land enters tapped.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Greed

Scrapheap

Whenever an artifact or enchantment is put into your graveyard from the battlefield, you gain 1 life.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Children of Korlis

Sacrifice this creature: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Sower of Discord

Flying
As this creature enters, choose two players.
Whenever damage is dealt to one of the chosen players, the other chosen player also loses that much life.

Sign in Blood

Target player draws two cards and loses 2 life.

Exquisite Archangel

Flying
If you would lose the game, instead exile this creature and your life total becomes equal to your starting life total.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Souls of the Faultless

Defender (This creature can't attack.)
Whenever this creature is dealt combat damage, you gain that much life and attacking player loses that much life.

Dockside Chef

{1}{B}, Sacrifice an artifact or creature: Draw a card.

Shineshadow Snarl

As this land enters, you may reveal a Plains or Swamp card from your hand. If you don't, this land enters tapped.
{T}: Add {W} or {B}.

Jinxed Choker

At the beginning of your end step, target opponent gains control of this artifact and puts a charge counter on it.
At the beginning of your upkeep, this artifact deals damage to you equal to the number of charge counters on it.
{3}: Put a charge counter on this artifact or remove one from it.

Divine Deflection

Prevent the next X damage that would be dealt to you and/or permanents you control this turn. If damage is prevented this way, Divine Deflection deals that much damage to any target.

Greater Harvester

At the beginning of your upkeep, sacrifice a permanent.
Whenever this creature deals combat damage to a player, that player sacrifices two permanents of their choice.

Nadier's Nightblade

Whenever a token you control leaves the battlefield, each opponent loses 1 life and you gain 1 life.

Illicit Shipment

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
Search your library for a card, put it into your hand, then shuffle.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Concealed Courtyard

This land enters tapped unless you control two or fewer other lands.
{T}: Add {W} or {B}.

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Leonin Elder

Whenever an artifact enters, you may gain 1 life.

Razaketh's Rite

Search your library for a card, put that card into your hand, then shuffle.
Cycling {B} ({B}, Discard this card: Draw a card.)

Trading Post

{1}, {T}, Discard a card: You gain 4 life.
{1}, {T}, Pay 1 life: Create a 0/1 white Goat creature token.
{1}, {T}, Sacrifice a creature: Return target artifact card from your graveyard to your hand.
{1}, {T}, Sacrifice an artifact: Draw a card.

Wishclaw Talisman

This artifact enters with three wish counters on it.
{1}, {T}, Remove a wish counter from this artifact: Search your library for a card, put it into your hand, then shuffle. An opponent gains control of this artifact. Activate only during your turn.

Grafted Butcher

When this creature enters, Phyrexians you control gain menace until end of turn.
Other Phyrexians you control get +1/+1.
{3}{B}, Sacrifice an artifact or creature: Return this card from your graveyard to the battlefield. Activate only as a sorcery.

Phyrexian Etchings

Cumulative upkeep {B} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of your end step, draw a card for each age counter on this enchantment.
When this enchantment is put into a graveyard from the battlefield, you lose 2 life for each age counter on it.

Needlebite Trap

If an opponent gained life this turn, you may pay {B} rather than pay this spell's mana cost.
Target player loses 5 life and you gain 5 life.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Syndicate Trafficker

{1}, Sacrifice an artifact: Put a +1/+1 counter on this creature. It gains indestructible until end of turn.

Profane Tutor

Suspend 2—{1}{B} (Rather than cast this card from your hand, pay {1}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Search your library for a card, put that card into your hand, then shuffle.

Castle Locthwain

This land enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Sorcerer's Broom

Whenever you sacrifice another permanent, you may pay {3}. If you do, create a token that's a copy of this creature.

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Moriok Rigger

Whenever an artifact is put into a graveyard from the battlefield, you may put a +1/+1 counter on this creature.

Kinzu of the Bleak Coven

Flying
Whenever another nontoken creature you control dies, you may pay 2 life and exile it. If you do, create a token that's a copy of that creature, except it's 1/1 and has toxic 1. (Players dealt combat damage by it also get a poison counter.)

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Isolated Chapel

This land enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Jinxed Ring

Whenever a nontoken permanent is put into your graveyard from the battlefield, this artifact deals 1 damage to you.
Sacrifice a creature: Target opponent gains control of this artifact. (This effect lasts indefinitely.)

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Rapacious Guest

Menace
Whenever one or more creatures you control deal combat damage to a player, create a Food token.
Whenever you sacrifice a Food, put a +1/+1 counter on this creature.
When this creature leaves the battlefield, target opponent loses life equal to its power.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Devour Flesh

Target player sacrifices a creature of their choice, then gains life equal to that creature's toughness.

Idyllic Tutor

Search your library for an enchantment card, reveal it, put it into your hand, then shuffle.

Grinding Station

{T}, Sacrifice an artifact: Target player mills three cards.
Whenever an artifact enters, you may untap this artifact.

Throne of Geth

{T}, Sacrifice an artifact: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Disciple of the Vault

Whenever an artifact is put into a graveyard from the battlefield, you may have target opponent lose 1 life.

Demonic Lore

When this enchantment enters, draw three cards.
At the beginning of your end step, you lose 2 life for each card in your hand.

Ovalchase Daredevil

Whenever an artifact you control enters, you may return this card from your graveyard to your hand.

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Torture Chamber

At the beginning of your upkeep, put a pain counter on this artifact.
At the beginning of your end step, this artifact deals damage to you equal to the number of pain counters on it.
{1}, {T}, Remove all pain counters from this artifact: It deals damage to target creature equal to the number of pain counters removed this way.

Drinker of Sorrow

This creature can't block.
Whenever this creature deals combat damage, sacrifice a permanent.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Withengar Unbound

Flying, intimidate, trample (A creature with intimidate can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a player loses the game, put thirteen +1/+1 counters on Withengar Unbound.

Elbrus, the Binding Blade

Equipped creature gets +1/+0.
When equipped creature deals combat damage to a player, unattach Elbrus, then transform it.
Equip {1}

Elbrus, the Binding Blade // Withengar Unbound

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice this enchantment: Each opponent loses 3 life. You gain life equal to the life lost this way.