Blot Out the Sky

Create X tapped 2/1 white and black Inkling creature tokens with flying. If X is 6 or more, destroy all noncreature, nonland permanents.

Blood Money

Destroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Nevinyrral, Urborg Tyrant

Hexproof from artifacts, creatures, and enchantments
When Nevinyrral, Urborg Tyrant enters, create a tapped 2/2 black Zombie creature token for each creature that died this turn.
When Nevinyrral dies, you may pay {1}. When you do, destroy all artifacts, creatures, and enchantments.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Fake Your Own Death

Until end of turn, target creature gets +2/+0 and gains "When this creature dies, return it to the battlefield tapped under its owner's control and you create a Treasure token." (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Kaya's Ghostform

Enchant creature or planeswalker you control
When enchanted permanent dies or is put into exile, return that card to the battlefield under your control.

Force of Despair

If it's not your turn, you may exile a black card from your hand rather than pay this spell's mana cost.
Destroy all creatures that entered this turn.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Wrath of God

Destroy all creatures. They can't be regenerated.

Bontu's Last Reckoning

Destroy all creatures. Lands you control don't untap during your next untap step.