Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Dregs of Sorrow

Destroy X target nonblack creatures. Draw X cards.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Immolating Souleater

{R/P}: This creature gets +1/+0 until end of turn. ({R/P} can be paid with either {R} or 2 life.)

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Locthwain Scorn

Target creature gets -3/-3 until end of turn. You gain 2 life.

Virtue of Persistence

At the beginning of your upkeep, put target creature card from a graveyard onto the battlefield under your control.

Virtue of Persistence // Locthwain Scorn

Carrion Howler

Pay 1 life: This creature gets +2/-1 until end of turn.

Manabarbs

Whenever a player taps a land for mana, this enchantment deals 1 damage to that player.

Breach the Multiverse

Each player mills ten cards. For each player, choose a creature or planeswalker card in that player's graveyard. Put those cards onto the battlefield under your control. Then each creature you control becomes a Phyrexian in addition to its other types.

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate this creature.

Rowan, Scion of War

Menace
{T}: Spells you cast this turn that are black and/or red cost {X} less to cast, where X is the amount of life you lost this turn. Activate only as a sorcery.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Greed

Infernal Grasp

Destroy target creature. You lose 2 life.

Marrow Bats

Flying
Pay 4 life: Regenerate this creature.

Souldrinker

Pay 3 life: Put a +1/+1 counter on this creature.

Song of Totentanz

Create X 1/1 black Rat creature tokens with "This token can't block." Creatures you control gain haste until end of turn.

Henrika, Infernal Seer

Flying, deathtouch, lifelink
{1}{B}{B}: Each creature you control with flying, deathtouch, and/or lifelink gets +1/+0 until end of turn.

Henrika Domnathi

Flying
At the beginning of combat on your turn, choose one that hasn't been chosen —
• Each player sacrifices a creature of their choice.
• You draw a card and you lose 1 life.
• Transform Henrika.

Henrika Domnathi // Henrika, Infernal Seer

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Shivan Devastator

Flying, haste
This creature enters with X +1/+1 counters on it.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Electrodominance

Electrodominance deals X damage to any target. You may cast a spell with mana value X or less from your hand without paying its mana cost.

Hellish Rebuke

Until end of turn, permanents your opponents control gain "When this permanent deals damage to the player who cast Hellish Rebuke, sacrifice this permanent. You lose 2 life."

Attempted Murder

Choose target creature. Roll X six-sided dice. For each even result, put two -1/-1 counters on that creature. For each odd result, create a 1/2 blue Bird creature token with flying named Storm Crow.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.

Cleaving Reaper

Flying, trample
Pay 3 life: Return this card from your graveyard to your hand. Activate only if you had an Angel or Berserker enter the battlefield under your control this turn.

Infernal Sovereign

Flying, trample
Skip your draw step.
Whenever you play a land or cast a spell, you draw a card and you lose 1 life.

Fire Covenant

As an additional cost to cast this spell, pay X life.
Fire Covenant deals X damage divided as you choose among any number of target creatures.

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

Hoarding Broodlord

Convoke
Flying
When this creature enters, search your library for a card, exile it face down, then shuffle. For as long as that card remains exiled, you may play it.
Spells you cast from exile have convoke.

Ramunap Ruins

{T}: Add {C}.
{T}, Pay 1 life: Add {R}.
{2}{R}{R}, {T}, Sacrifice a Desert: This land deals 2 damage to each opponent.

Illicit Auction

Each player may bid life for control of target creature. You start the bidding with a bid of 0. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and gains control of the creature. (This effect lasts indefinitely.)

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Vesper Ghoul

{T}, Pay 1 life: Add one mana of any color.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Dark Ritual

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Finale of Eternity

Destroy up to three target creatures with toughness X or less. If X is 10 or more, return all creature cards from your graveyard to the battlefield.

Tibalt, Cosmic Impostor

As Tibalt enters, you get an emblem with "You may play cards exiled with Tibalt, Cosmic Impostor, and you may spend mana as though it were mana of any color to cast those spells."
+2: Exile the top card of each player's library.
−3: Exile target artifact or creature.
−8: Exile all graveyards. Add {R}{R}{R}.

Valki, God of Lies

When Valki enters, each opponent reveals their hand. For each opponent, exile a creature card they revealed this way until Valki leaves the battlefield.
{X}: Choose a creature card exiled with Valki with mana value X. Valki becomes a copy of that card.

Valki, God of Lies // Tibalt, Cosmic Impostor

Hall of the Bandit Lord

Hall of the Bandit Lord enters tapped.
{T}, Pay 3 life: Add {C}. If that mana is spent on a creature spell, it gains haste.

Assault on Osgiliath

Amass Orcs X, then Goblins and Orcs you control gain double strike and haste until end of turn. (To amass Orcs X, put X +1/+1 counters on an Army you control. It's also an Orc. If you don't control an Army, create a 0/0 black Orc Army creature token first.)

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Fireball

This spell costs {1} more to cast for each target beyond the first.
Fireball deals X damage divided evenly, rounded down, among any number of targets.

Stormfist Crusader

Menace
At the beginning of your upkeep, each player draws a card and loses 1 life.

Biotransference

Creatures you control are artifacts in addition to their other types. The same is true for creature spells you control and creature cards you own that aren't on the battlefield.
Whenever you cast an artifact spell, you lose 1 life and create a 2/2 black Necron Warrior artifact creature token.

Boseiju, Who Shelters All

Boseiju enters tapped.
{T}, Pay 2 life: Add {C}. If that mana is spent on an instant or sorcery spell, that spell can't be countered.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Cruel Bargain

Draw four cards. You lose half your life, rounded up.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Tavern Swindler

{T}, Pay 3 life: Flip a coin. If you win the flip, you gain 6 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Graveborn Muse

At the beginning of your upkeep, you draw X cards and you lose X life, where X is the number of Zombies you control.

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.

Balduvian Rage

Target attacking creature gets +X/+0 until end of turn.
Draw a card at the beginning of the next turn's upkeep.

Black Sun's Twilight

Up to one target creature gets -X/-X until end of turn. If X is 5 or more, return a creature card with mana value X or less from your graveyard to the battlefield tapped.

Their Number Is Legion

Create X tapped 2/2 black Necron Warrior artifact creature tokens, then you gain life equal to the number of artifacts you control. Exile Their Number Is Legion.
You may cast this card from your graveyard.

Greven, Predator Captain

Menace
Greven gets +X/+0, where X is the amount of life you've lost this turn.
Whenever Greven attacks, you may sacrifice another creature. If you do, you draw cards equal to that creature's power and you lose life equal to that creature's toughness.

Ifnir Deadlands

{T}: Add {C}.
{T}, Pay 1 life: Add {B}.
{2}{B}{B}, {T}, Sacrifice a Desert: Put two -1/-1 counters on target creature an opponent controls. Activate only as a sorcery.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Castle Locthwain

This land enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Ayara, Furnace Queen

At the beginning of combat on your turn, return up to one target artifact or creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step.

Ayara, Widow of the Realm

{T}, Sacrifice another creature or artifact: Ayara deals X damage to target opponent or battle and you gain X life, where X is the sacrificed permanent's mana value.
{5}{R/P}: Transform Ayara. Activate only as a sorcery. ({R/P} can be paid with either {R} or 2 life.)

Ayara, Widow of the Realm // Ayara, Furnace Queen

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When this Siege enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Battle at the Bridge

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Target creature gets -X/-X until end of turn. You gain X life.

Crater's Claws

Crater's Claws deals X damage to any target.
Ferocious — Crater's Claws deals X plus 2 damage instead if you control a creature with power 4 or greater.

Jaya's Immolating Inferno

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Jaya's Immolating Inferno deals X damage to each of up to three targets.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Grave Endeavor

Roll two d10 and choose one result. Return a creature card from your graveyard to the battlefield with a number of +1/+1 counters on it equal to that result. Then each opponent loses X life and you gain X life, where X is the other result.

Entreat the Dead

Return X target creature cards from your graveyard to the battlefield.
Miracle {X}{B}{B} (You may cast this card for its miracle cost when you draw it if it's the first card you drew this turn.)

Tor Wauki the Younger

Reach, lifelink
If another source you control would deal noncombat damage to a permanent or player, it deals that much damage plus 1 to that permanent or player instead.
Whenever you cast an instant or sorcery spell, Tor Wauki deals 2 damage to any target.

Sudden Demise

Choose a color. Sudden Demise deals X damage to each creature of the chosen color.

Defiler of Instinct

First strike
As an additional cost to cast red permanent spells, you may pay 2 life. Those spells cost {R} less to cast if you paid life this way. This effect reduces only the amount of red mana you pay.
Whenever you cast a red permanent spell, this creature deals 1 damage to any target.

Gix's Command

Choose two —
• Put two +1/+1 counters on up to one creature. It gains lifelink until end of turn.
• Destroy each creature with power 2 or less.
• Return up to two creature cards from your graveyard to your hand.
• Each opponent sacrifices a creature with the greatest power among creatures they control.

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap this artifact.

Double Vision

Whenever you cast your first instant or sorcery spell each turn, copy that spell. You may choose new targets for the copy.

Apex of Power

Exile the top seven cards of your library. Until end of turn, you may cast spells from among them.
If this spell was cast from your hand, add ten mana of any one color.

Storm King's Thunder

When you next cast an instant or sorcery spell this turn, copy that spell X times. You may choose new targets for the copies.

Phyrexian Lens

Shadowcloak Vampire

Pay 2 life: This creature gains flying until end of turn. (It can't be blocked except by creatures with flying or reach.)

Deepwood Ghoul

Sol Ring

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Lord Skitter's Blessing

When this enchantment enters, create a Wicked Role token attached to target creature you control. (Enchanted creature gets +1/+1. When this token is put into a graveyard, each opponent loses 1 life.)
At the beginning of your draw step, if you control an enchanted creature, you lose 1 life and you draw an additional card.

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Asmodeus the Archfiend

Binding Contract — If you would draw a card, exile the top card of your library face down instead.
{B}{B}{B}: Draw seven cards.
{B}: Return all cards exiled with Asmodeus to their owner's hand and you lose that much life.

Dreadhorde Invasion

At the beginning of your upkeep, you lose 1 life and amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)
Whenever a Zombie token you control with power 6 or greater attacks, it gains lifelink until end of turn.

Banefire

Banefire deals X damage to any target.
If X is 5 or more, this spell can't be countered and the damage can't be prevented.

Arco-Flagellant

Squad {2} (As an additional cost to cast this spell, you may pay {2} any number of times. When this creature enters, create that many tokens that are copies of it.)
This creature can't block.
Endurant — Pay 3 life: This creature gains indestructible until end of turn.

Devil's Play

Devil's Play deals X damage to any target.
Flashback {X}{R}{R}{R} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Unspeakable Symbol

Pay 3 life: Put a +1/+1 counter on target creature.

Myr Convert

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
{T}, Pay 2 life: Add one mana of any color.