Catastrophe

Destroy all lands or all creatures. Creatures destroyed this way can't be regenerated.

Negate

Freyalise, Llanowar's Fury

+2: Create a 1/1 green Elf Druid creature token with "{T}: Add {G}."
−2: Destroy target artifact or enchantment.
−6: Draw a card for each green creature you control.
Freyalise, Llanowar's Fury can be your commander.

Biophagus

Genomic Enhancement — {T}: Add one mana of any color. If this mana is spent to cast a creature spell, that creature enters with an additional +1/+1 counter on it.

Calix, Destiny's Hand

+1: Look at the top four cards of your library. You may reveal an enchantment card from among them and put that card into your hand. Put the rest on the bottom of your library in a random order.
−3: Exile target creature or enchantment you don't control until target enchantment you control leaves the battlefield.
−7: Return all enchantment cards from your graveyard to the battlefield.

Oko, Thief of Crowns

+2: Create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
+1: Target artifact or creature loses all abilities and becomes a green Elk creature with base power and toughness 3/3.
−5: Exchange control of target artifact or creature you control and target creature an opponent controls with power 3 or less.

Final Judgment

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Wrenn and Realmbreaker

Lands you control have "{T}: Add one mana of any color."
+1: Up to one target land you control becomes a 3/3 Elemental creature with vigilance, hexproof, and haste until your next turn. It's still a land.
−2: Mill three cards. You may put a permanent card from among the milled cards into your hand.
−7: You get an emblem with "You may play lands and cast permanent spells from your graveyard."

Moon-Blessed Cleric

Divine Intervention — When Moon-Blessed Cleric enters, you may search your library for an enchantment card, reveal it, then shuffle and put that card on top.

Descend upon the Sinful

Exile all creatures.
Delirium — Create a 4/4 white Angel creature token with flying if there are four or more card types among cards in your graveyard.

The Eternal Wanderer

No more than one creature can attack The Eternal Wanderer each combat.
+1: Exile up to one target artifact or creature. Return that card to the battlefield under its owner's control at the beginning of that player's next end step.
0: Create a 2/2 white Samurai creature token with double strike.
−4: For each player, choose a creature that player controls. Each player sacrifices all creatures they control not chosen this way.

Urza's Ruinous Blast

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Exile all nonland permanents that aren't legendary.

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Tainted Observer

Flying
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever another creature you control enters, you may pay {2}. If you do, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Sparkshaper Visionary

At the beginning of combat on your turn, choose any number of target planeswalkers you control. Until end of turn, they become 3/3 blue Bird creatures with flying, hexproof, and "Whenever this creature deals combat damage to a player, scry 1." (They're no longer planeswalkers. Loyalty abilities can still be activated.)

Onakke Oathkeeper

Creatures can't attack planeswalkers you control unless their controller pays {1} for each creature they control that's attacking a planeswalker you control.
{4}{W}{W}, Exile Onakke Oathkeeper from your graveyard: Return target planeswalker card from your graveyard to the battlefield.

Ever-Watching Threshold

Whenever an opponent attacks, if they attacked you and/or a planeswalker you control, draw a card.

Forbidding Spirit

When Forbidding Spirit enters, until your next turn, creatures can't attack you or planeswalkers you control unless their controller pays {2} for each of those creatures.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Karn's Bastion

{T}: Add {C}.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Birds of Paradise

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Copper Longlegs

Reach
{1}{G}, Sacrifice Copper Longlegs: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Day of Judgment

Idyllic Tutor

Search your library for an enchantment card, reveal it, put it into your hand, then shuffle.

Nissa, Voice of Zendikar

+1: Create a 0/1 green Plant creature token.
−2: Put a +1/+1 counter on each creature you control.
−7: You gain X life and draw X cards, where X is the number of lands you control.

Vivien, Champion of the Wilds

You may cast creature spells as though they had flash.
+1: Until your next turn, up to one target creature gains vigilance and reach.
−2: Look at the top three cards of your library. Exile one face down and put the rest on the bottom of your library in any order. For as long as it remains exiled, you may cast it if it's a creature spell.

Huatli's Raptor

Vigilance
When Huatli's Raptor enters, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

The Wanderer

Prevent all noncombat damage that would be dealt to you and other permanents you control.
−2: Exile target creature with power 4 or greater.

Counterspell

Heart of Kiran

Flying, vigilance
Crew 3 (Tap any number of creatures you control with total power 3 or more: This Vehicle becomes an artifact creature until end of turn.)
You may remove a loyalty counter from a planeswalker you control rather than pay Heart of Kiran's crew cost.

Plea for Guidance

Search your library for up to two enchantment cards, reveal them, put them into your hand, then shuffle.

Jiang Yanggu, Wildcrafter

Each creature you control with a +1/+1 counter on it has "{T}: Add one mana of any color."
−1: Put a +1/+1 counter on target creature.

Sunfall

Exile all creatures. Incubate X, where X is the number of creatures exiled this way. (Create an Incubator token with X +1/+1 counters on it and "{2}: Transform this artifact." It transforms into a 0/0 Phyrexian artifact creature.)

Dovin, Grand Arbiter

+1: Until end of turn, whenever a creature you control deals combat damage to a player, put a loyalty counter on Dovin, Grand Arbiter.
−1: Create a 1/1 colorless Thopter artifact creature token with flying. You gain 1 life.
−7: Look at the top ten cards of your library. Put three of them into your hand and the rest on the bottom of your library in a random order.

Ornithopter of Paradise

Expel the Interlopers

Choose a number between 0 and 10. Destroy all creatures with power greater than or equal to the chosen number.

Bloated Contaminator

Trample
Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever Bloated Contaminator deals combat damage to a player, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Llanowar Elves

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Wrath of God

Destroy all creatures. They can't be regenerated.

Dovin, Hand of Control

Artifact, instant, and sorcery spells your opponents cast cost {1} more to cast.
−1: Until your next turn, prevent all damage that would be dealt to and dealt by target permanent an opponent controls.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.