Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Painful Truths

Converge — You draw X cards and you lose X life, where X is the number of colors of mana spent to cast this spell.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Zurgo Helmsmasher

Haste
Zurgo Helmsmasher attacks each combat if able.
During your turn, Zurgo Helmsmasher has indestructible.
Whenever a creature dealt damage by Zurgo Helmsmasher this turn dies, put a +1/+1 counter on Zurgo Helmsmasher.

Wrath of God

Destroy all creatures. They can't be regenerated.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Crackling Doom

Crackling Doom deals 2 damage to each opponent. Each opponent sacrifices a creature with the greatest power among creatures that player controls.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.