Ulamog, the Infinite Gyre

When you cast this spell, destroy target permanent.
Indestructible
Annihilator 4 (Whenever this creature attacks, defending player sacrifices four permanents of their choice.)
When Ulamog, the Infinite Gyre is put into a graveyard from anywhere, its owner shuffles their graveyard into their library.

Palantír of Orthanc

At the beginning of your end step, put an influence counter on Palantír of Orthanc and scry 2. Then target opponent may have you draw a card. If that player doesn't, you mill X cards, where X is the number of influence counters on Palantír of Orthanc, and that player loses life equal to the total mana value of those cards.

Angel of Suffering

Flying
If damage would be dealt to you, prevent that damage and mill twice that many cards.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Living Death

Each player exiles all creature cards from their graveyard, then sacrifices all creatures they control, then puts all cards they exiled this way onto the battlefield.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Bile Blight

Target creature and all other creatures with the same name as that creature get -3/-3 until end of turn.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Footbottom Feast

Put any number of target creature cards from your graveyard on top of your library.
Draw a card.

Entomb

Search your library for a card, put that card into your graveyard, then shuffle.

Ghoulcaller Gisa

{B}, {T}, Sacrifice another creature: Create X 2/2 black Zombie creature tokens, where X is the sacrificed creature's power.

Corpse Churn

Mill three cards, then you may return a creature card from your graveyard to your hand. (To mill three cards, put the top three cards of your library into your graveyard.)

Grim Haruspex

Morph {B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)
Whenever another nontoken creature you control dies, draw a card.

Sol Ring

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Mesmeric Orb

Whenever a permanent becomes untapped, that permanent's controller mills a card.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Volrath's Stronghold

{T}: Add {C}.
{1}{B}, {T}: Put target creature card from your graveyard on top of your library.

Basalt Monolith

Basalt Monolith doesn't untap during your untap step.
{T}: Add {C}{C}{C}.
{3}: Untap Basalt Monolith.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Temple of the False God

{T}: Add {C}{C}. Activate only if you control five or more lands.

Swamp

Demonic Tutor

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Grindstone

{3}, {T}: Target player mills two cards. If two cards that share a color were milled this way, repeat this process.

Millikin

{T}, Mill a card: Add {C}. (To mill a card, put the top card of your library into your graveyard.)

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

No Mercy

Whenever a creature deals damage to you, destroy it.

Witch-king of Angmar

Flying
Whenever one or more creatures deal combat damage to you, each opponent sacrifices a creature of their choice that dealt combat damage to you this turn. The Ring tempts you.
Discard a card: Witch-king of Angmar gains indestructible until end of turn. Tap it.

Witch's Cottage

({T}: Add {B}.)
Witch's Cottage enters tapped unless you control three or more other Swamps.
When Witch's Cottage enters untapped, you may put target creature card from your graveyard on top of your library.

One Ring to Rule Them All

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — The Ring tempts you, then each player mills cards equal to your Ring-bearer's power.
II — Destroy all nonlegendary creatures.
III — Each opponent loses 1 life for each creature card in that player's graveyard.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Phyrexian Tower

{T}: Add {C}.
{T}, Sacrifice a creature: Add {B}{B}.

Eye Collector

Flying
Whenever Eye Collector deals combat damage to a player, each player mills a card. (Each player puts the top card of their library into their graveyard.)

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Throne of Death

At the beginning of your upkeep, mill a card.
{2}{B}, {T}, Exile a creature card from your graveyard: Draw a card.

Egon, God of Death

Deathtouch
At the beginning of your upkeep, exile two cards from your graveyard. If you can't, sacrifice Egon and draw a card.

Egon, God of Death // Throne of Death

Golgari Thug

When Golgari Thug dies, put target creature card from your graveyard on top of your library.
Dredge 4 (If you would draw a card, you may mill four cards instead. If you do, return this card from your graveyard to your hand.)

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Ambition's Cost

You draw three cards and you lose 3 life.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Bloodchief's Thirst

Kicker {2}{B} (You may pay an additional {2}{B} as you cast this spell.)
Destroy target creature or planeswalker with mana value 2 or less. If this spell was kicked, instead destroy target creature or planeswalker.

Bone Shards

As an additional cost to cast this spell, sacrifice a creature or discard a card.
Destroy target creature or planeswalker.

The Dross Pits

The Dross Pits enters tapped.
{T}: Add {B}.
{1}{B}, {T}, Sacrifice The Dross Pits: Draw a card.

Drivnod, Carnage Dominus

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
{B/P}{B/P}, Exile three creature cards from your graveyard: Put an indestructible counter on Drivnod, Carnage Dominus. ({B/P} can be paid with either {B} or 2 life.)

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Viscera Seer

Sacrifice a creature: Scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Balustrade Spy

Flying
When Balustrade Spy enters, target player reveals cards from the top of their library until they reveal a land card, then puts those cards into their graveyard.

Massacre Girl

Menace
When Massacre Girl enters, each other creature gets -1/-1 until end of turn. Whenever a creature dies this turn, each creature other than Massacre Girl gets -1/-1 until end of turn.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Damnation

Destroy all creatures. They can't be regenerated.

Altar of the Brood

Whenever another permanent you control enters, each opponent mills a card.

Gorging Vulture

Flying
When Gorging Vulture enters, mill four cards. You gain 1 life for each creature card milled this way. (To mill four cards, put the top four cards of your library into your graveyard.)

Painter's Servant

As Painter's Servant enters, choose a color.
All cards that aren't on the battlefield, spells, and permanents are the chosen color in addition to their other colors.

Dictate of Erebos

Flash
Whenever a creature you control dies, each opponent sacrifices a creature of their choice.

Shriekmaw

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
When Shriekmaw enters, destroy target nonartifact, nonblack creature.
Evoke {1}{B} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Undercity Informer

{1}, Sacrifice a creature: Target player reveals cards from the top of their library until they reveal a land card, then puts those cards into their graveyard.

Varragoth, Bloodsky Sire

Deathtouch
Boast — {1}{B}: Target player searches their library for a card, then shuffles and puts that card on top. (Activate only if this creature attacked this turn and only once each turn.)

Phyrexian Altar

Sacrifice a creature: Add one mana of any color.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Bloodsoaked Champion

Bloodsoaked Champion can't block.
Raid — {1}{B}: Return Bloodsoaked Champion from your graveyard to the battlefield. Activate only if you attacked this turn.

Dark Ritual

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

The Tabernacle at Pendrell Vale

All creatures have "At the beginning of your upkeep, destroy this creature unless you pay {1}."

Morality Shift

Exchange your graveyard and library. Then shuffle your library.

Tortured Existence

{B}, Discard a creature card: Return target creature card from your graveyard to your hand.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Strip Mine

{T}: Add {C}.
{T}, Sacrifice Strip Mine: Destroy target land.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.