Eternal Isolation

Put target creature with power 4 or greater on the bottom of its owner's library.

Death Cloud

Each player loses X life, discards X cards, sacrifices X creatures of their choice, then sacrifices X lands of their choice.

Swallowing Plague

Swallowing Plague deals X damage to target creature and you gain X life.

Fevered Visions

At the beginning of each player's end step, that player draws a card. If the player is your opponent and has four or more cards in hand, Fevered Visions deals 2 damage to that player.

Isolate

Exile target permanent with mana value 1.

Certain Death

Destroy target creature. Its controller loses 2 life and you gain 2 life.

Brink of Disaster

Enchant creature or land
When enchanted permanent becomes tapped, destroy it.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Karona's Zealot

Morph {3}{W}{W} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)
When Karona's Zealot is turned face up, all damage that would be dealt to it this turn is dealt to target creature instead.

Consuming Vapors

Target player sacrifices a creature of their choice. You gain life equal to that creature's toughness.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Suffocating Fumes

Creatures your opponents control get -1/-1 until end of turn.
Cycling {2} ({2}, Discard this card: Draw a card.)

Isolated Watchtower

{T}: Add {C}.
{2}, {T}: Scry 1, then you may reveal the top card of your library. If a basic land card is revealed this way, put it onto the battlefield tapped. Activate only if an opponent controls at least two more lands than you.

Amaranthine Wall

Defender
{2}: Amaranthine Wall gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Mountain

Act of Heroism

Untap target creature. It gets +2/+2 until end of turn and can block an additional creature this turn.

Engineered Plague

As Engineered Plague enters, choose a creature type.
All creatures of the chosen type get -1/-1.

Protective Bubble

Enchant creature
Enchanted creature can't be blocked and has shroud. (It can't be the target of spells or abilities.)

Isolation Zone

When Isolation Zone enters, exile target creature or enchantment an opponent controls until Isolation Zone leaves the battlefield. (That permanent returns under its owner's control.)

Wall of Distortion

Defender (This creature can't attack.)
{2}{B}, {T}: Target player discards a card. Activate only as a sorcery.

Disaster Radius

As an additional cost to cast this spell, reveal a creature card from your hand.
Disaster Radius deals X damage to each creature your opponents control, where X is the revealed card's mana value.

Void Beckoner

Deathtouch
Cycling {2}{B} ({2}{B}, Discard this card: Draw a card.)
When you cycle Void Beckoner, put a deathtouch counter on target creature you control.

Plaguebearer

{X}{X}{B}: Destroy target nonblack creature with mana value X.

Mask of Avacyn

Equipped creature gets +1/+2 and has hexproof. (It can't be the target of spells or abilities your opponents control.)
Equip {3}

Safe Haven

{2}, {T}: Exile target creature you control.
At the beginning of your upkeep, you may sacrifice Safe Haven. If you do, return each card exiled with Safe Haven to the battlefield under its owner's control.

Fevered Convulsions

{2}{B}{B}: Put a -1/-1 counter on target creature.

Sphere of Safety

Creatures can't attack you or planeswalkers you control unless their controller pays {X} for each of those creatures, where X is the number of enchantments you control.

Contagion

You may pay 1 life and exile a black card from your hand rather than pay this spell's mana cost.
Distribute two -2/-1 counters among one or two target creatures.

Isolated Chapel

Isolated Chapel enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Panic Attack

Up to three target creatures can't block this turn.

Mass Hysteria

Diseased Vermin

Whenever Diseased Vermin deals combat damage to a player, put an infection counter on it.
At the beginning of your upkeep, Diseased Vermin deals X damage to target opponent previously dealt damage by it, where X is the number of infection counters on it.

Suffocating Blast

Counter target spell and Suffocating Blast deals 3 damage to target creature.

Deputized Protester

Menace (This creature can't be blocked except by two or more creatures.)
Melee (Whenever this creature attacks, it gets +1/+1 until end of turn for each opponent you attacked this combat.)

Instill Infection

Put a -1/-1 counter on target creature.
Draw a card.

Blighted Agent

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Blighted Agent can't be blocked.

Leadership Vacuum

Target player returns each commander they control from the battlefield to the command zone.
Draw a card.

Suffocation

Cast this spell only if you were dealt damage this turn by a red instant or sorcery spell.
Suffocation deals 4 damage to the controller of the last red instant or sorcery spell that dealt damage to you this turn.
Draw a card at the beginning of the next turn's upkeep.

Fear

Enchant creature (Target a creature as you cast this. This card enters attached to that creature.)
Enchanted creature has fear. (It can't be blocked except by artifact creatures and/or black creatures.)

Disease Carriers

When Disease Carriers dies, target creature gets -2/-2 until end of turn.

Quarantine Field

Quarantine Field enters with X isolation counters on it.
When Quarantine Field enters, for each isolation counter on it, exile up to one target nonland permanent an opponent controls until Quarantine Field leaves the battlefield.

Inkmoth Nexus

{T}: Add {C}.
{1}: Inkmoth Nexus becomes a 1/1 Phyrexian Blinkmoth artifact creature with flying and infect until end of turn. It's still a land. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Careful Consideration

Target player draws four cards, then discards three cards. If you cast this spell during your main phase, instead that player draws four cards, then discards two cards.

Traveling Plague

Enchant creature
At the beginning of each upkeep, put a plague counter on Traveling Plague.
Enchanted creature gets -1/-1 for each plague counter on Traveling Plague.
When enchanted creature leaves the battlefield, that creature's controller returns Traveling Plague from its owner's graveyard to the battlefield.

Plague Myr

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
{T}: Add {C}.

Contagion Clasp

When Contagion Clasp enters, put a -1/-1 counter on target creature.
{4}, {T}: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Comeuppance

Prevent all damage that would be dealt to you and planeswalkers you control this turn by sources you don't control. If damage from a creature source is prevented this way, Comeuppance deals that much damage to that creature. If damage from a noncreature source is prevented this way, Comeuppance deals that much damage to the source's controller.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Infectious Horror

Whenever Infectious Horror attacks, each opponent loses 2 life.

Island

Melira, Sylvok Outcast

You can't get poison counters.
Creatures you control can't have -1/-1 counters put on them.
Creatures your opponents control lose infect.

Time Stop

End the turn. (Exile all spells and abilities, including this spell. The player whose turn it is discards down to their maximum hand size. Damage heals and "this turn" and "until end of turn" effects end.)

Edifice of Authority

{1}, {T}: Target creature can't attack this turn. Put a brick counter on Edifice of Authority.
{1}, {T}: Until your next turn, target creature can't attack or block and its activated abilities can't be activated. Activate only if there are three or more brick counters on Edifice of Authority.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Wall of Denial

Defender, flying
Shroud (This creature can't be the target of spells or abilities.)

City of Solitude

Players can cast spells and activate abilities only during their own turns.

Steel Wall

Keep Safe

Counter target spell that targets a permanent you control.
Draw a card.

Carrion Wall

Defender (This creature can't attack.)
{1}{B}: Regenerate Carrion Wall.

Impending Disaster

At the beginning of your upkeep, if there are seven or more lands on the battlefield, sacrifice Impending Disaster and destroy all lands.

Angelic Wall

Defender (This creature can't attack.)
Flying

Panic

Cast this spell only during combat before blockers are declared.
Target creature can't block this turn.
Draw a card at the beginning of the next turn's upkeep.

Forest

Wall of Deceit

Defender (This creature can't attack.)
{3}: Turn Wall of Deceit face down.
Morph {U} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Contagion Engine

When Contagion Engine enters, put a -1/-1 counter on each creature target player controls.
{4}, {T}: Proliferate twice. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Frontline Medic

Battalion — Whenever Frontline Medic and at least two other creatures attack, creatures you control gain indestructible until end of turn.
Sacrifice Frontline Medic: Counter target spell with {X} in its mana cost unless its controller pays {3}.

Corpse Cur

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Corpse Cur enters, you may return target creature card with infect from your graveyard to your hand.

Goblin Medics

Whenever Goblin Medics becomes tapped, it deals 1 damage to any target.

Dust Corona

Enchant creature
Enchanted creature gets +2/+0 and can't be blocked by creatures with flying.

Perpetual Timepiece

{T}: Mill two cards.
{2}, Exile Perpetual Timepiece: Shuffle any number of target cards from your graveyard into your library.

Combat Medic

{1}{W}: Prevent the next 1 damage that would be dealt to any target this turn.

Rotlung Reanimator

Whenever Rotlung Reanimator or another Cleric dies, create a 2/2 black Zombie creature token.

Heroes Remembered

You gain 20 life.
Suspend 10—{W} (Rather than cast this card from your hand, you may pay {W} and exile it with ten time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)

Widespread Panic

Whenever a spell or ability causes its controller to shuffle their library, that player puts a card from their hand on top of their library.

Swamp

Karona, False God

Haste
At the beginning of each player's upkeep, that player untaps Karona, False God and gains control of it.
Whenever Karona attacks, creatures of the creature type of your choice get +3/+3 until end of turn.

Contagious Nim

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Plains

Strength of Isolation

Enchant creature
Enchanted creature gets +1/+2 and has protection from black.
Madness {W} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Shizo, Death's Storehouse

{T}: Add {B}.
{B}, {T}: Target legendary creature gains fear until end of turn. (It can't be blocked except by artifact creatures and/or black creatures.)

Incite Hysteria

Radiance — Until end of turn, target creature and each other creature that shares a color with it gain "This creature can't block."