Ramos, Dragon Engine

Flying
Whenever you cast a spell, put a +1/+1 counter on Ramos for each of that spell's colors.
Remove five +1/+1 counters from Ramos: Add {W}{W}{U}{U}{B}{B}{R}{R}{G}{G}. Activate only once each turn.

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Oppression

Whenever a player casts a spell, that player discards a card.

Hymn to Tourach

Target player discards two cards at random.

Nicol Bolas, Planeswalker

+3: Destroy target noncreature permanent.
−2: Gain control of target creature.
−9: Nicol Bolas, Planeswalker deals 7 damage to target player or planeswalker. That player or that planeswalker's controller discards seven cards, then sacrifices seven permanents of their choice.

Tyrannize

Target player discards their hand unless they pay 7 life.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

The Rack

As The Rack enters, choose an opponent.
At the beginning of the chosen player's upkeep, The Rack deals X damage to that player, where X is 3 minus the number of cards in their hand.

Surly Badgersaur

Whenever you discard a creature card, put a +1/+1 counter on Surly Badgersaur.
Whenever you discard a land card, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")
Whenever you discard a noncreature, nonland card, Surly Badgersaur fights up to one target creature you don't control.

Hypnotic Specter

Flying
Whenever Hypnotic Specter deals damage to an opponent, that player discards a card at random.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Nicol Bolas, Dragon-God

Nicol Bolas, Dragon-God has all loyalty abilities of all other planeswalkers on the battlefield.
+1: You draw a card. Each opponent exiles a card from their hand or a permanent they control.
−3: Destroy target creature or planeswalker.
−8: Each opponent who doesn't control a legendary creature or planeswalker loses the game.

Awaken the Erstwhile

Each player discards all the cards in their hand, then creates that many 2/2 black Zombie creature tokens.

Oblivion Crown

Flash (You may cast this spell any time you could cast an instant.)
Enchant creature
Enchanted creature has "Discard a card: This creature gets +1/+1 until end of turn."

Kroxa, Titan of Death's Hunger

When Kroxa enters, sacrifice it unless it escaped.
Whenever Kroxa enters or attacks, each opponent discards a card, then each opponent who didn't discard a nonland card this way loses 3 life.
Escape—{B}{B}{R}{R}, Exile five other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Black Vise

As Black Vise enters, choose an opponent.
At the beginning of the chosen player's upkeep, Black Vise deals X damage to that player, where X is the number of cards in their hand minus 4.

Cursed Rack

As Cursed Rack enters, choose an opponent.
The chosen player's maximum hand size is four.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Windfall

Each player discards their hand, then draws cards equal to the greatest number of cards a player discarded this way.

The Haunt of Hightower

Flying, lifelink
Whenever The Haunt of Hightower attacks, defending player discards a card.
Whenever a card is put into an opponent's graveyard from anywhere, put a +1/+1 counter on The Haunt of Hightower.

Bone Miser

Whenever you discard a creature card, create a 2/2 black Zombie creature token.
Whenever you discard a land card, add {B}{B}.
Whenever you discard a noncreature, nonland card, draw a card.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Dreamborn Muse

At the beginning of each player's upkeep, that player mills X cards, where X is the number of cards in their hand.

Dark Suspicions

At the beginning of each opponent's upkeep, that player loses X life, where X is the number of cards in that player's hand minus the number of cards in your hand.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Fell Specter

Flying
When Fell Specter enters, target opponent discards a card.
Whenever an opponent discards a card, that player loses 2 life.

Deathrite Shaman

{T}: Exile target land card from a graveyard. Add one mana of any color.
{B}, {T}: Exile target instant or sorcery card from a graveyard. Each opponent loses 2 life.
{G}, {T}: Exile target creature card from a graveyard. You gain 2 life.

Nicol Bolas, God-Pharaoh

+2: Target opponent exiles cards from the top of their library until they exile a nonland card. Until end of turn, you may cast that card without paying its mana cost.
+1: Each opponent exiles two cards from their hand.
−4: Nicol Bolas, God-Pharaoh deals 7 damage to target opponent, creature an opponent controls, or planeswalker an opponent controls.
−12: Exile each nonland permanent your opponents control.

Rielle, the Everwise

Rielle, the Everwise gets +1/+0 for each instant and sorcery card in your graveyard.
Whenever you discard one or more cards for the first time each turn, draw that many cards.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Rackling

At the beginning of each opponent's upkeep, Rackling deals X damage to that player, where X is 3 minus the number of cards in their hand.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Pain Magnification

Whenever an opponent is dealt 3 or more damage by a single source, that player discards a card.

Malfegor

Flying
When Malfegor enters, discard your hand. Each opponent sacrifices a creature of their choice for each card discarded this way.

Hollowborn Barghest

At the beginning of your upkeep, if you have no cards in hand, each opponent loses 2 life.
At the beginning of each opponent's upkeep, if that player has no cards in hand, they lose 2 life.

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Stabwhisker the Odious

At the beginning of each opponent's upkeep, that player loses 1 life for each card fewer than three in their hand.

Nezumi Shortfang

{1}{B}, {T}: Target opponent discards a card. Then if that player has no cards in hand, flip Nezumi Shortfang.

Nezumi Shortfang // Stabwhisker the Odious

Nicol Bolas

Flying
At the beginning of your upkeep, sacrifice Nicol Bolas unless you pay {U}{B}{R}.
Whenever Nicol Bolas deals damage to an opponent, that player discards their hand.

Nicol Bolas, the Arisen

+2: Draw two cards.
−3: Nicol Bolas, the Arisen deals 10 damage to target creature or planeswalker.
−4: Put target creature or planeswalker card from a graveyard onto the battlefield under your control.
−12: Exile all but the bottom card of target player's library.

Nicol Bolas, the Ravager

Flying
When Nicol Bolas, the Ravager enters, each opponent discards a card.
{4}{U}{B}{R}: Exile Nicol Bolas, the Ravager, then return him to the battlefield transformed under his owner's control. Activate only as a sorcery.

Nicol Bolas, the Ravager // Nicol Bolas, the Arisen

Sol Ring

Skullcage

At the beginning of each opponent's upkeep, Skullcage deals 2 damage to that player unless they have exactly three or exactly four cards in hand.

Mind Slash

{B}, Sacrifice a creature: Target opponent reveals their hand. You choose a card from it. That player discards that card. Activate only as a sorcery.

Geth's Grimoire

Whenever an opponent discards a card, you may draw a card.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Wheel of Fortune

Each player discards their hand, then draws seven cards.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Wheel of Torture

At the beginning of each opponent's upkeep, Wheel of Torture deals X damage to that player, where X is 3 minus the number of cards in their hand.

Mind Twist

Target player discards X cards at random.

Mindslicer

When Mindslicer dies, each player discards their hand.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Cruel Ultimatum

Target opponent sacrifices a creature of their choice, discards three cards, then loses 5 life. You return a creature card from your graveyard to your hand, draw three cards, then gain 5 life.

Archfiend of Ifnir

Flying
Whenever you cycle or discard another card, put a -1/-1 counter on each creature your opponents control.
Cycling {2} ({2}, Discard this card: Draw a card.)

Narset, Parter of Veils

Each opponent can't draw more than one card each turn.
−2: Look at the top four cards of your library. You may reveal a noncreature, nonland card from among them and put it into your hand. Put the rest on the bottom of your library in a random order.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Underworld Breach

Each nonland card in your graveyard has escape. The escape cost is equal to the card's mana cost plus exile three other cards from your graveyard. (You may cast cards from your graveyard for their escape cost.)
At the beginning of the end step, sacrifice Underworld Breach.

Lavaborn Muse

At the beginning of each opponent's upkeep, if that player has two or fewer cards in hand, Lavaborn Muse deals 3 damage to that player.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")