Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Go for the Throat

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Graveyard Glutton

Ward—Discard a card.
Whenever Graveyard Glutton enters or attacks, exile up to two target cards from graveyards. For each creature card exiled this way, each opponent loses 1 life and you gain 1 life.
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Graveyard Trespasser

Ward—Discard a card.
Whenever Graveyard Trespasser enters or attacks, exile up to one target card from a graveyard. If a creature card was exiled this way, each opponent loses 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Graveyard Trespasser // Graveyard Glutton

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Sol Ring

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Liliana's Triumph

Each opponent sacrifices a creature. If you control a Liliana planeswalker, each opponent also discards a card.

Ancient Craving

You draw three cards and you lose 3 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Blood Pact

Tymaret, Chosen from Death

Tymaret's toughness is equal to your devotion to black. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
{1}{B}: Exile up to two target cards from graveyards. You gain 1 life for each creature card exiled this way.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Vecna

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature.
• Each opponent sacrifices a creature token.
• Each opponent sacrifices a planeswalker.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Pile On

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy target creature or planeswalker. Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Tevesh Szat, Doom of Fools

+2: Create two 0/1 black Thrull creature tokens.
+1: You may sacrifice another creature or planeswalker. If you do, draw two cards, then draw another card if the sacrificed permanent was a commander.
−10: Gain control of all commanders. Put all commanders from the command zone onto the battlefield under your control.
Tevesh Szat, Doom of Fools can be your commander.
Partner

Burnished Hart

{3}, Sacrifice Burnished Hart: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Ambition's Cost

Shriekmaw

Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
When Shriekmaw enters, destroy target nonartifact, nonblack creature.
Evoke {1}{B} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

The Book of Vile Darkness

At the beginning of your end step, if you lost 2 or more life this turn, create a 2/2 black Zombie creature token.
{T}, Exile The Book of Vile Darkness and artifacts you control named Eye of Vecna and Hand of Vecna: Create Vecna, a legendary 8/8 black Zombie God creature token with indestructible and all triggered abilities of the exiled cards.

Thought Vessel

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Asmodeus the Archfiend

Binding Contract — If you would draw a card, exile the top card of your library face down instead.
{B}{B}{B}: Draw seven cards.
{B}: Return all cards exiled with Asmodeus the Archfiend to their owner's hand and you lose that much life.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Wishclaw Talisman

Wishclaw Talisman enters with three wish counters on it.
{1}, {T}, Remove a wish counter from Wishclaw Talisman: Search your library for a card, put it into your hand, then shuffle. An opponent gains control of Wishclaw Talisman. Activate only during your turn.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Tenacious Underdog

Blitz—{2}{B}{B}, Pay 2 life. (If you cast this spell for its blitz cost, it gains haste and "When this creature dies, draw a card." Sacrifice it at the beginning of the next end step.)
You may cast Tenacious Underdog from your graveyard using its blitz ability.

Ravenloft Adventurer

When Ravenloft Adventurer enters, you take the initiative.
If a creature an opponent controls would die, instead exile it and put a hit counter on it.
Whenever Ravenloft Adventurer attacks, if you've completed a dungeon, defending player loses 1 life for each card they own in exile with a hit counter on it.

Sedgemoor Witch

Menace
Ward—Pay 3 life. (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays 3 life.)
Magecraft — Whenever you cast or copy an instant or sorcery spell, create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."

Night's Whisper

Nirkana Revenant

Whenever you tap a Swamp for mana, add an additional {B}.
{B}: Nirkana Revenant gets +1/+1 until end of turn.

Gilded Lotus

Kothophed, Soul Hoarder

Flying
Whenever a permanent owned by another player is put into a graveyard from the battlefield, you draw a card and you lose 1 life.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

Ivory Tower

At the beginning of your upkeep, you gain X life, where X is the number of cards in your hand minus 4.

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth, Spider Queen.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Necromantic Selection

Destroy all creatures, then return a creature card put into a graveyard this way to the battlefield under your control. It's a black Zombie in addition to its other colors and types. Exile Necromantic Selection.

Swamp

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Lethal Scheme

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy target creature or planeswalker. Each creature that convoked Lethal Scheme connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on that creature.)

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Callous Bloodmage

When Callous Bloodmage enters, choose one —
• Create a 1/1 black and green Pest creature token with "When this creature dies, you gain 1 life."
• You draw a card and you lose 1 life.
• Exile target player's graveyard.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Field of Ruin

{T}: Add {C}.
{2}, {T}, Sacrifice Field of Ruin: Destroy target nonbasic land an opponent controls. Each player searches their library for a basic land card, puts it onto the battlefield, then shuffles.

Vindictive Lich

When Vindictive Lich dies, choose one or more. Each mode must target a different player.
• Target opponent sacrifices a creature.
• Target opponent discards two cards.
• Target opponent loses 5 life.

Liliana Vess

+1: Target player discards a card.
−2: Search your library for a card, then shuffle and put that card on top.
−8: Put all creature cards from all graveyards onto the battlefield under your control.

Oubliette

When Oubliette enters, target creature phases out until Oubliette leaves the battlefield. Tap that creature as it phases in this way. (Auras and Equipment phase out with it. While permanents are phased out, they're treated as though they don't exist.)

Szat's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Each opponent sacrifices a creature they control with the greatest power.
• Exile all opponents' graveyards, then create X 0/1 black Thrull creature tokens, where X is the greatest power among creature cards exiled this way.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Grief

Menace
When Grief enters, target opponent reveals their hand. You choose a nonland card from it. That player discards that card.
Evoke—Exile a black card from your hand.

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Scour from Existence

Morbid Opportunist

Whenever one or more other creatures die, draw a card. This ability triggers only once each turn.