Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Akroma's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Creatures you control gain flying, vigilance, and double strike until end of turn.
• Creatures you control gain lifelink, indestructible, and protection from each color until end of turn.

Avacyn, Angel of Hope

Flying, vigilance, indestructible
Other permanents you control have indestructible.

Disaster Radius

As an additional cost to cast this spell, reveal a creature card from your hand.
Disaster Radius deals X damage to each creature your opponents control, where X is the revealed card's mana value.

Starfall Invocation

Gift a card (You may promise an opponent a gift as you cast this spell. If you do, they draw a card before its other effects.)
Destroy all creatures. If the gift was promised, return a creature card put into your graveyard this way to the battlefield under your control.

Sunblast Angel

Flying
When Sunblast Angel enters, destroy all tapped creatures.

Avacyn, the Purifier

Flying
When this creature transforms into Avacyn, the Purifier, it deals 3 damage to each other creature and each opponent.

Archangel Avacyn

Flash
Flying, vigilance
When Archangel Avacyn enters, creatures you control gain indestructible until end of turn.
When a non-Angel creature you control dies, transform Archangel Avacyn at the beginning of the next upkeep.

Archangel Avacyn // Avacyn, the Purifier

The Battle of Bywater

Destroy all creatures with power 3 or greater. Then create a Food token for each creature you control. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Mother of Runes

{T}: Target creature you control gains protection from the color of your choice until end of turn.

Plains

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Sundown Pass

Sundown Pass enters tapped unless you control two or more other lands.
{T}: Add {R} or {W}.

Unexpected Windfall

As an additional cost to cast this spell, discard a card.
Draw two cards and create two Treasure tokens. (They're artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Flawless Maneuver

If you control a commander, you may cast this spell without paying its mana cost.
Creatures you control gain indestructible until end of turn.

Spires of Orazca

(Transforms from Thaumatic Compass.)
{T}: Add {C}.
{T}: Untap target attacking creature an opponent controls and remove it from combat.

Thaumatic Compass

{3}, {T}: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.
At the beginning of your end step, if you control seven or more lands, transform Thaumatic Compass.

Thaumatic Compass // Spires of Orazca

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Battlefield Forge

{T}: Add {C}.
{T}: Add {R} or {W}. Battlefield Forge deals 1 damage to you.

Ondu Skyruins

Ondu Skyruins enters tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Spectator Seating

Spectator Seating enters tapped unless you have two or more opponents.
{T}: Add {R} or {W}.

Clifftop Retreat

Clifftop Retreat enters tapped unless you control a Mountain or a Plains.
{T}: Add {R} or {W}.

City of Brass

Whenever City of Brass becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Planar Cleansing

Kindred Boon

As Kindred Boon enters, choose a creature type.
{1}{W}: Put a divinity counter on target creature you control of the chosen type.
Each creature you control with a divinity counter on it has indestructible.

Red Elemental Blast

Choose one —
• Counter target blue spell.
• Destroy target blue permanent.

Winds of Rath

Destroy all creatures that aren't enchanted. They can't be regenerated.

Sephara, Sky's Blade

You may pay {W} and tap four untapped creatures you control with flying rather than pay this spell's mana cost.
Flying, lifelink
Other creatures you control with flying have indestructible. (Damage and effects that say "destroy" don't destroy them.)

Barren Glory

At the beginning of your upkeep, if you control no permanents other than Barren Glory and have no cards in hand, you win the game.

Tajic, Blade of the Legion

Indestructible
Battalion — Whenever Tajic, Blade of the Legion and at least two other creatures attack, Tajic gets +5/+5 until end of turn.

Linvala, Keeper of Silence

Flying
Activated abilities of creatures your opponents control can't be activated.

Big Score

Wrath of God

Destroy all creatures. They can't be regenerated.

Lapse of Certainty

Counter target spell. If that spell is countered this way, put it on top of its owner's library instead of into that player's graveyard.

Mountain

Day of Judgment

Dismantling Wave

For each opponent, destroy up to one target artifact or enchantment that player controls.
Cycling {6}{W}{W} ({6}{W}{W}, Discard this card: Draw a card.)
When you cycle Dismantling Wave, destroy all artifacts and enchantments.

Selfless Spirit

Flying
Sacrifice Selfless Spirit: Creatures you control gain indestructible until end of turn.

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Chandra, Torch of Defiance

+1: Exile the top card of your library. You may cast that card. If you don't, Chandra, Torch of Defiance deals 2 damage to each opponent.
+1: Add {R}{R}.
−3: Chandra, Torch of Defiance deals 4 damage to target creature.
−7: You get an emblem with "Whenever you cast a spell, this emblem deals 5 damage to any target."

Lightning Bolt

Lightning Bolt deals 3 damage to any target.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Akroma, Angel of Fury

This spell can't be countered.
Flying, trample, protection from white and from blue
{R}: Akroma, Angel of Fury gets +1/+0 until end of turn.
Morph {3}{R}{R}{R} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Giver of Runes

{T}: Another target creature you control gains protection from colorless or from the color of your choice until end of turn.

Pyroblast

Choose one —
• Counter target spell if it's blue.
• Destroy target permanent if it's blue.

Teshar, Ancestor's Apostle

Flying
Whenever you cast a historic spell, return target creature card with mana value 3 or less from your graveyard to the battlefield. (Artifacts, legendaries, and Sagas are historic.)

Boromir, Warden of the Tower

Vigilance
Whenever an opponent casts a spell, if no mana was spent to cast it, counter that spell.
Sacrifice Boromir, Warden of the Tower: Creatures you control gain indestructible until end of turn. The Ring tempts you.

Sanctum of the Sun

(Transforms from Azor's Gateway.)
{T}: Add X mana of any one color, where X is your life total.

Azor's Gateway

{1}, {T}: Draw a card, then exile a card from your hand. If cards with five or more different mana values are exiled with Azor's Gateway, you gain 5 life, untap Azor's Gateway, and transform it.

Azor's Gateway // Sanctum of the Sun

Laelia, the Blade Reforged

Haste
Whenever Laelia, the Blade Reforged attacks, exile the top card of your library. You may play that card this turn.
Whenever one or more cards are put into exile from your library and/or your graveyard, put a +1/+1 counter on Laelia.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Lightshield Array

At the beginning of your end step, put a +1/+1 counter on each creature that attacked this turn.
Sacrifice Lightshield Array: Creatures you control gain hexproof and indestructible until end of turn.

Invasion of Gobakhan

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Gobakhan enters, look at target opponent's hand. You may exile a nonland card from it. For as long as that card remains exiled, its owner may play it. A spell cast this way costs {2} more to cast.

Invasion of Gobakhan // Lightshield Array

Lae'zel's Acrobatics

Exile all nontoken creatures you control, then roll a d20.
1—9 | Return those cards to the battlefield under their owner's control at the beginning of the next end step.
10—20 | Return those cards to the battlefield under their owner's control, then exile them again. Return those cards to the battlefield under their owner's control at the beginning of the next end step.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Breathkeeper Seraph

Flying, soulbond (You may pair this creature with another unpaired creature when either enters. They remain paired for as long as you control both of them.)
As long as Breathkeeper Seraph is paired with another creature, each of those creatures has "When this creature dies, you may return it to the battlefield under its owner's control at the beginning of your next upkeep."

Hushbringer

Flying, lifelink
Creatures entering or dying don't cause abilities to trigger.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Get Lost

Destroy target creature, enchantment, or planeswalker. Its controller creates two Map tokens. (They're artifacts with "{1}, {T}, Sacrifice this artifact: Target creature you control explores. Activate only as a sorcery.")

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Koth of the Hammer

+1: Untap target Mountain. It becomes a 4/4 red Elemental creature until end of turn. It's still a land.
−2: Add {R} for each Mountain you control.
−5: You get an emblem with "Mountains you control have '{T}: This land deals 1 damage to any target.'"

Lost Vale

(Transforms from Dowsing Dagger.)
{T}: Add three mana of any one color.

Dowsing Dagger

When Dowsing Dagger enters, target opponent creates two 0/2 green Plant creature tokens with defender.
Equipped creature gets +2/+1.
Whenever equipped creature deals combat damage to a player, you may transform Dowsing Dagger.
Equip {2}

Dowsing Dagger // Lost Vale

Sol Ring

Kirtar's Wrath

Destroy all creatures. They can't be regenerated.
Threshold — If seven or more cards are in your graveyard, instead destroy all creatures, then create two 1/1 white Spirit creature tokens with flying. Creatures destroyed this way can't be regenerated.

Aegis Angel

Flying (This creature can't be blocked except by creatures with flying or reach.)
When Aegis Angel enters, another target permanent gains indestructible for as long as you control Aegis Angel. (Effects that say "destroy" don't destroy it. A creature with indestructible can't be destroyed by damage.)

Elspeth, Knight-Errant

+1: Create a 1/1 white Soldier creature token.
+1: Target creature gets +3/+3 and gains flying until end of turn.
−8: You get an emblem with "Artifacts, creatures, enchantments, and lands you control have indestructible."

Urza's Ruinous Blast

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Exile all nonland permanents that aren't legendary.