Nuclear Fallout

Each creature gets twice -X/-X until end of turn. Each player gets X rad counters.

V.A.T.S.

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Choose any number of target creatures with equal toughness. Destroy the chosen creatures.

Struggle for Project Purity

As Struggle for Project Purity enters, choose Brotherhood or Enclave.
• Brotherhood — At the beginning of your upkeep, each opponent draws a card. You draw a card for each card drawn this way.
• Enclave — Whenever a player attacks you with one or more creatures, that player gets twice that many rad counters.

Sentinel Sarah Lyons

Haste
As long as an artifact entered the battlefield under your control this turn, creatures you control get +2/+2.
Battalion — Whenever Sentinel Sarah Lyons and at least two other creatures attack, Sentinel Sarah Lyons deals damage equal to the number of artifacts you control to target player.

Silver Shroud Costume

Flash
When Silver Shroud Costume enters, attach it to target creature you control. That creature gains shroud until end of turn. (It can't be the target of spells or abilities.)
Equipped creature can't be blocked.
Equip {3}

Wild Wasteland

Skip your draw step.
At the beginning of your upkeep, exile the top two cards of your library. You may play those cards this turn.

Synth Infiltrator

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
You may have Synth Infiltrator enter as a copy of any creature on the battlefield, except it's a Synth artifact creature in addition to its other types.

Overencumbered

Enchant opponent
When Overencumbered enters, enchanted opponent creates a Clue token, a Food token, and a Junk token.
At the beginning of combat on enchanted opponent's turn, that player may pay {1} for each artifact they control. If they don't, creatures can't attack this combat.

Vault 75: Middle School

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Exile all creatures with power 4 or greater.
II, III — Put a +1/+1 counter on each creature you control.

Strong Back

Enchant creature
Equip abilities you activate that target enchanted creature cost {3} less to activate.
Aura spells you cast that target enchanted creature cost {3} less to cast.
Enchanted creature gets +2/+2 for each Aura and Equipment attached to it.

Well Rested

Enchant creature
Enchanted creature has "Whenever this creature becomes untapped, put two +1/+1 counters on it, then you gain 2 life and draw a card. This ability triggers only once each turn."

Grim Reaper's Sprint

Morbid — This spell costs {3} less to cast if a creature died this turn.
Enchant creature
When Grim Reaper's Sprint enters, untap each creature you control. If it's your main phase, there is an additional combat phase after this phase.
Enchanted creature gets +2/+2 and has haste.