Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Hofri Ghostforge

Spirits you control get +1/+1 and have trample and haste.
Whenever another nontoken creature you control dies, exile it. If you do, create a token that's a copy of that creature, except it's a Spirit in addition to its other types and it has "When this token leaves the battlefield, return the exiled card to its owner's graveyard."

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Teysa Karlov

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
Creature tokens you control have vigilance and lifelink.

The Kenriths' Royal Funeral

When The Kenriths' Royal Funeral enters, exile up to two target legendary creature cards from your graveyard. You draw X cards and you lose X life, where X is the greatest mana value among cards exiled this way.
Legendary spells you cast cost {1} less to cast for each card exiled with The Kenriths' Royal Funeral.

Otharri, Suns' Glory

Flying, lifelink, haste
Whenever Otharri attacks, you get an experience counter. Then create a 2/2 red Rebel creature token that's tapped and attacking for each experience counter you have.
{2}{R}{W}, Tap an untapped Rebel you control: Return this card from your graveyard to the battlefield tapped.

Arvad the Cursed

Deathtouch, lifelink
Other legendary creatures you control get +2/+2.

Tivash, Gloom Summoner

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay X life, where X is the amount of life you gained this turn. If you do, create an X/X black Demon creature token with flying.

Brion Stoutarm

Lifelink
{R}, {T}, Sacrifice another creature: Brion Stoutarm deals damage equal to the sacrificed creature's power to target player or planeswalker.

Verrak, Warped Sengir

Flying, deathtouch, lifelink
Whenever you activate an ability that isn't a mana ability, if life was paid to activate it, you may pay that much life again. If you do, copy that ability. You may choose new targets for the copy.

Mortarion, Daemon Primarch

Flying
Primarch of the Death Guard — At the beginning of your end step, you may pay {X}. If you do, create X 2/2 black Astartes Warrior creature tokens with menace. X can't be greater than the amount of life you lost this turn.

Elenda and Azor

Flying, ward {2}
Whenever Elenda and Azor attacks, you may pay {X}{W}{U}{B}. If you do, draw X cards.
At the beginning of each end step, you may pay 4 life. If you do, create a number of 1/1 black Vampire Knight creature tokens with lifelink equal to the number of cards you've drawn this turn.

Elenda, the Dusk Rose

Lifelink
Whenever another creature dies, put a +1/+1 counter on Elenda.
When Elenda dies, create X 1/1 white Vampire creature tokens with lifelink, where X is Elenda's power.

Stronghold Arena

Kicker {G} and/or {W} (You may pay an additional {G} and/or {W} as you cast this spell.)
When this enchantment enters, you gain 3 life for each time it was kicked.
Whenever one or more creatures you control deal combat damage to a player, you may reveal the top card of your library and put it into your hand. If you do, you lose life equal to its mana value.

Teneb, the Harvester

Flying
Whenever Teneb deals combat damage to a player, you may pay {2}{B}. If you do, put target creature card from a graveyard onto the battlefield under your control.

Anrakyr the Traveller

Lord of the Pyrrhian Legions — Whenever Anrakyr the Traveller attacks, you may cast an artifact spell from your hand or graveyard by paying life equal to its mana value rather than paying its mana cost.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Alquist Proft, Master Sleuth

Vigilance
When Alquist Proft enters, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")
{X}{W}{U}{U}, {T}, Sacrifice a Clue: You draw X cards and gain X life.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Shanid, Sleepers' Scourge

Menace
Other legendary creatures you control have menace.
Whenever you play a legendary land or cast a legendary spell, you draw a card and you lose 1 life.

Vona, Butcher of Magan

Vigilance, lifelink
{T}, Pay 7 life: Destroy target nonland permanent. Activate only during your turn.

Awaken the Blood Avatar

As an additional cost to cast this spell, you may sacrifice any number of creatures. This spell costs {2} less to cast for each creature sacrificed this way.
Each opponent sacrifices a creature of their choice. Create a 3/6 black and red Avatar creature token with haste and "Whenever this token attacks, it deals 3 damage to each opponent."

Extus, Oriq Overlord

Double strike
Magecraft — Whenever you cast or copy an instant or sorcery spell, return target nonlegendary creature card from your graveyard to your hand.

Extus, Oriq Overlord // Awaken the Blood Avatar

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Sapling of Colfenor

Indestructible
Whenever Sapling of Colfenor attacks, reveal the top card of your library. If it's a creature card, you gain life equal to that card's toughness, lose life equal to its power, then put it into your hand.

Erebos, Bleak-Hearted

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature.
Whenever another creature you control dies, you may pay 2 life. If you do, draw a card.
{1}{B}, Sacrifice another creature: Target creature gets -2/-1 until end of turn.

Firesong and Sunspeaker

Red instant and sorcery spells you control have lifelink.
Whenever a white instant or sorcery spell causes you to gain life, Firesong and Sunspeaker deals 3 damage to target creature or player.

Ovika, Enigma Goliath

Flying
Ward—{3}, Pay 3 life.
Whenever you cast a noncreature spell, create X 1/1 red Phyrexian Goblin creature tokens, where X is the mana value of that spell. They gain haste until end of turn.

Dihada, Binder of Wills

+2: Up to one target legendary creature gains vigilance, lifelink, and indestructible until your next turn.
−3: Reveal the top four cards of your library. Put any number of legendary cards from among them into your hand and the rest into your graveyard. Create a Treasure token for each card put into your graveyard this way.
−11: Gain control of all nonland permanents until end of turn. Untap them. They gain haste until end of turn.
Dihada, Binder of Wills can be your commander.

Amalia Benavides Aguirre

Ward—Pay 3 life.
Whenever you gain life, Amalia Benavides Aguirre explores. Then destroy all other creatures if its power is exactly 20. (To have this creature explore, reveal the top card of your library. Put that card into your hand if it's a land. Otherwise, put a +1/+1 counter on this creature, then put the card back or put it into your graveyard.)

Will, Scion of Peace

Vigilance
{T}: Spells you cast this turn that are white and/or blue cost {X} less to cast, where X is the amount of life you gained this turn. Activate only as a sorcery.

Sol Ring

Rassilon, the War President

At the beginning of your upkeep, you lose 2 life and exile the top card of your library. You may play that card for as long as it remains exiled.
Each noncreature spell you cast from exile has conspire. (As you cast that spell, you may tap two untapped creatures you control that share a color with it. When you do, copy it and you may choose new targets for the copy.)

Alela, Artful Provocateur

Flying, deathtouch, lifelink
Other creatures you control with flying get +1/+0.
Whenever you cast an artifact or enchantment spell, create a 1/1 blue Faerie creature token with flying.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Craig Boone, Novac Guard

Reach, lifelink
One for My Baby — Whenever you attack with two or more creatures, put two quest counters on Craig Boone. When you do, Craig Boone deals damage equal to the number of quest counters on it to up to one target creature unless that creature's controller has Craig Boone deal that much damage to them.

Sorin, Lord of Innistrad

+1: Create a 1/1 black Vampire creature token with lifelink.
−2: You get an emblem with "Creatures you control get +1/+0."
−6: Destroy up to three target creatures and/or other planeswalkers. Return each card put into a graveyard this way to the battlefield under your control.

Queza, Augur of Agonies

Whenever you draw a card, target opponent loses 1 life and you gain 1 life.

Tor Wauki the Younger

Reach, lifelink
If another source you control would deal noncombat damage to a permanent or player, it deals that much damage plus 1 to that permanent or player instead.
Whenever you cast an instant or sorcery spell, Tor Wauki deals 2 damage to any target.

Death Grasp

Death Grasp deals X damage to any target. You gain X life.

The Gaffer

At the beginning of each end step, if you gained 3 or more life this turn, draw a card.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Lorehold Command

Choose two —
• Create a 3/2 red and white Spirit creature token.
• Creatures you control get +1/+0 and gain indestructible and haste until end of turn.
• Lorehold Command deals 3 damage to any target. Target player gains 3 life.
• Sacrifice a permanent, then draw two cards.

Rowan, Scion of War

Menace
{T}: Spells you cast this turn that are black and/or red cost {X} less to cast, where X is the amount of life you lost this turn. Activate only as a sorcery.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

The Archimandrite

At the beginning of your upkeep, you gain X life, where X is the number of cards in your hand minus 4.
Whenever you gain life, each Advisor, Artificer, and Monk you control gains vigilance and gets +X/+0 until end of turn, where X is the amount of life you gained.
Tap three untapped Advisors, Artificers, and/or Monks you control: Draw a card.

Bane, Lord of Darkness

As long as your life total is less than or equal to half your starting life total, Bane has indestructible.
Whenever another nontoken creature you control dies, target opponent may have you draw a card. If they don't, you may put a creature card with equal or lesser toughness from your hand onto the battlefield.

Blitzwing, Adaptive Assailant

Living metal (During your turn, this Vehicle is also a creature.)
At the beginning of combat on your turn, choose flying or indestructible at random. Blitzwing gains that ability until end of turn.
Whenever Blitzwing deals combat damage to a player, convert it.

Blitzwing, Cruel Tormentor

More Than Meets the Eye {3}{B} (You may cast this card converted for {3}{B}.)
At the beginning of your end step, target opponent loses life equal to the life that player lost this turn. If no life is lost this way, convert Blitzwing.

Blitzwing, Cruel Tormentor // Blitzwing, Adaptive Assailant

Kenrith, the Returned King

{R}: All creatures gain trample and haste until end of turn.
{1}{G}: Put a +1/+1 counter on target creature.
{2}{W}: Target player gains 5 life.
{3}{U}: Target player draws a card.
{4}{B}: Put target creature card from a graveyard onto the battlefield under its owner's control.

Gollum, Obsessed Stalker

Skulk (This creature can't be blocked by creatures with greater power.)
At the beginning of your end step, each opponent dealt combat damage this game by a creature named Gollum, Obsessed Stalker loses life equal to the amount of life you gained this turn.