Sign in Blood

Target player draws two cards and loses 2 life.

Murder

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Merrow Bonegnawer

{T}: Target player exiles a card from their graveyard.
Whenever you cast a black spell, you may untap Merrow Bonegnawer.

Bile Urchin

Sacrifice Bile Urchin: Target player loses 1 life.

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Pharika's Chosen

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Swamp

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.