Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

Isareth the Awakener

Deathtouch
Whenever Isareth attacks, you may pay {X}. When you do, return target creature card with mana value X from your graveyard to the battlefield with a corpse counter on it. If that creature would leave the battlefield, exile it instead of putting it anywhere else.

Tymna the Weaver

Lifelink
At the beginning of each of your postcombat main phases, you may pay X life, where X is the number of opponents that were dealt combat damage this turn. If you do, draw X cards.
Partner (You can have two commanders if both have partner.)

Serra Ascendant

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
As long as you have 30 or more life, this creature gets +5/+5 and has flying.

Embodiment of Agonies

Flying, deathtouch
This creature enters with a +1/+1 counter on it for each different mana cost among nonland cards in your graveyard. (For example, {2}{B} and {1}{B}{B} are different mana costs.)

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is this creature's power.

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Swamp

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on this enchantment. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if this enchantment has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Hired Poisoner

Orcish Bowmasters

Flash
When this creature enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, this creature deals 1 damage to any target. Then amass Orcs 1.

Chivalric Alliance

Whenever you attack with two or more creatures, draw a card.
{2}, Discard a card: Create a 2/2 white and blue Knight creature token with vigilance.

Plains

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Drannith Magistrate

Your opponents can't cast spells from anywhere other than their hands.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Flawless Maneuver

If you control a commander, you may cast this spell without paying its mana cost.
Creatures you control gain indestructible until end of turn.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Profane Insight

You draw a card and you lose 1 life. (Then exile this card. You may cast the creature later from exile.)

Foulmire Knight

Foulmire Knight // Profane Insight

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Arcane Signet

Fracture

Destroy target artifact, enchantment, or planeswalker.

Dark Ritual

Isolated Chapel

This land enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Guildsworn Prowler

Deathtouch
When this creature dies, if it wasn't blocking, draw a card.

Firemane Commando

Flying
Whenever you attack with two or more creatures, draw a card.
Whenever another player attacks with two or more creatures, they draw a card if none of those creatures attacked you.

Breena, the Demagogue

Flying
Whenever a player attacks one of your opponents, if that opponent has more life than another of your opponents, that attacking player draws a card and you put two +1/+1 counters on a creature you control.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Ancient Tomb

{T}: Add {C}{C}. This land deals 2 damage to you.

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Bloodthirsty Blade

Equipped creature gets +2/+0 and is goaded. (It attacks each combat if able and attacks a player other than you if able.)
{1}: Attach this Equipment to target creature an opponent controls. Activate only as a sorcery.

Orzhov Enforcer

Deathtouch
Afterlife 1 (When this creature dies, create a 1/1 white and black Spirit creature token with flying.)

Sol Ring

Gifted Aetherborn

Vault of Champions

This land enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Malakir Familiar

Flying, deathtouch
Whenever you gain life, this creature gets +1/+1 until end of turn.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Liesa, Forgotten Archangel

Flying, lifelink
Whenever another nontoken creature you control dies, return that card to its owner's hand at the beginning of the next end step.
If a creature an opponent controls would die, exile it instead.

Tinybones, the Pickpocket

Deathtouch
Whenever Tinybones deals combat damage to a player, you may cast target nonland permanent card from that player's graveyard, and mana of any type can be spent to cast that spell.

Grim Hireling

Whenever one or more creatures you control deal combat damage to a player, create two Treasure tokens.
{B}, Sacrifice X Treasures: Target creature gets -X/-X until end of turn. Activate only as a sorcery.

Nighthawk Scavenger

Flying, deathtouch, lifelink
Nighthawk Scavenger's power is equal to 1 plus the number of card types among cards in your opponents' graveyards.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice this creature: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Charismatic Conqueror

Vigilance
Whenever an artifact or creature an opponent controls enters untapped, they may tap that permanent. If they don't, you create a 1/1 white Vampire creature token with lifelink.

Shattered Sanctum

This land enters tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Vampire of the Dire Moon

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Graveblade Marauder

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever this creature deals combat damage to a player, that player loses life equal to the number of creature cards in your graveyard.

Elas il-Kor, Sadistic Pilgrim

Deathtouch
Whenever another creature you control enters, you gain 1 life.
Whenever another creature you control dies, each opponent loses 1 life.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Tomik, Wielder of Law

Affinity for planeswalkers (This spell costs {1} less to cast for each planeswalker you control.)
Flying, vigilance
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, that opponent loses 3 life and you draw a card.

Selfless Spirit

Flying
Sacrifice this creature: Creatures you control gain indestructible until end of turn.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Rancid Rats

Skulk (This creature can't be blocked by creatures with greater power.)
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Kambal, Profiteering Mayor

Whenever one or more tokens your opponents control enter, for each of them, create a tapped token that's a copy of it. This ability triggers only once each turn.
Whenever one or more tokens you control enter, each opponent loses 1 life and you gain 1 life.

Preacher of the Schism

Deathtouch
Whenever this creature attacks the player with the most life or tied for most life, create a 1/1 white Vampire creature token with lifelink.
Whenever this creature attacks while you have the most life or are tied for most life, you draw a card and you lose 1 life.