Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Drannith Magistrate

Your opponents can't cast spells from anywhere other than their hands.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Dark Ritual

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Swamp

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Cabal Ritual

Add {B}{B}{B}.
Threshold — Add {B}{B}{B}{B}{B} instead if seven or more cards are in your graveyard.

Aether Snap

Remove all counters from all permanents and exile all tokens.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Sensei's Divining Top

{1}: Look at the top three cards of your library, then put them back in any order.
{T}: Draw a card, then put Sensei's Divining Top on top of its owner's library.

Mox Amber

{T}: Add one mana of any color among legendary creatures and planeswalkers you control.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Caltrops

Whenever a creature attacks, Caltrops deals 1 damage to it.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Plains

Grasp of Darkness

Target creature gets -4/-4 until end of turn.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Culling the Weak

As an additional cost to cast this spell, sacrifice a creature.
Add {B}{B}{B}{B}.

Sol Ring

Angel of Despair

Flying
When Angel of Despair enters, destroy target permanent.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Darksteel Mutation

Enchant creature
Enchanted creature is an Insect artifact creature with base power and toughness 0/1 and has indestructible, and it loses all other abilities, card types, and creature types.

Virulent Plague

Expedition Map

{2}, {T}, Sacrifice Expedition Map: Search your library for a land card, reveal it, put it into your hand, then shuffle.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Entomb

Search your library for a card, put that card into your graveyard, then shuffle.

Jeweled Lotus

{T}, Sacrifice Jeweled Lotus: Add three mana of any one color. Spend this mana only to cast your commander.

Trespasser's Curse

Enchant player
Whenever a creature enchanted player controls enters, that player loses 1 life and you gain 1 life.

Deathbringer Liege

Other white creatures you control get +1/+1.
Other black creatures you control get +1/+1.
Whenever you cast a white spell, you may tap target creature.
Whenever you cast a black spell, you may destroy target creature if it's tapped.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Demonic Tutor

Cut Down

Destroy target creature with total power and toughness 5 or less.

Illness in the Ranks

Guardian of the Gateless

Flying
Guardian of the Gateless can block any number of creatures.
Whenever Guardian of the Gateless blocks, it gets +1/+1 until end of turn for each creature it's blocking.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Toxrill, the Corrosive

At the beginning of each end step, put a slime counter on each creature you don't control.
Creatures you don't control get -1/-1 for each slime counter on them.
Whenever a creature you don't control with a slime counter on it dies, create a 1/1 black Slug creature token.
{U}{B}, Sacrifice a Slug: Draw a card.

Athreos, God of Passage

Indestructible
As long as your devotion to white and black is less than seven, Athreos isn't a creature.
Whenever another creature you own dies, return it to your hand unless target opponent pays 3 life.

Elesh Norn, Grand Cenobite

Vigilance
Other creatures you control get +2/+2.
Creatures your opponents control get -2/-2.

Rush of Dread

Spree (Choose one or more additional costs.)
+ {1} — Target opponent sacrifices half the creatures they control of their choice, rounded up.
+ {2} — Target opponent discards half the cards in their hand, rounded up.
+ {2} — Target opponent loses half their life, rounded up.

Ulcerate

Target creature gets -3/-3 until end of turn. You lose 3 life.

Night of Souls' Betrayal

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Nirkana Revenant

Whenever you tap a Swamp for mana, add an additional {B}.
{B}: Nirkana Revenant gets +1/+1 until end of turn.

Thoughtseize

Target player reveals their hand. You choose a nonland card from it. That player discards that card. You lose 2 life.

Orim's Prayer

Whenever one or more creatures attack you, you gain 1 life for each attacking creature.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Defense Grid

Each spell costs {3} more to cast except during its controller's turn.

Lotus Petal

{T}, Sacrifice Lotus Petal: Add one mana of any color.

No Mercy

Whenever a creature deals damage to you, destroy it.

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents of their choice.

Vein Ripper

Flying
Ward—Sacrifice a creature.
Whenever a creature dies, target opponent loses 2 life and you gain 2 life.

Elesh Norn, Mother of Machines

Vigilance
If a permanent entering causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
Permanents entering don't cause abilities of permanents your opponents control to trigger.

Soul Warden

Whenever another creature enters, you gain 1 life.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.